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Hemostatic non-viscous material and preparation method thereof

An anti-adhesion and hemostatic layer technology, applied in the field of medical materials, can solve the problems of poor anti-adhesion effect and hemostatic effect, etc., and achieve the effects of increasing the anti-adhesion effect, improving the mechanical strength, and increasing the hemostatic effect.

Active Publication Date: 2015-09-02
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a hemostatic and anti-adhesion material and a preparation method thereof to solve the problems of poor anti-adhesion and hemostatic effects of anti-adhesion materials in the prior art

Method used

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  • Hemostatic non-viscous material and preparation method thereof
  • Hemostatic non-viscous material and preparation method thereof
  • Hemostatic non-viscous material and preparation method thereof

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preparation example Construction

[0039] The present invention also provides a preparation method of a hemostatic and anti-adhesion material, comprising:

[0040] performing an activated cross-linking reaction with the film-forming solution prepared from the first type of absorbable polymer material and an activator to obtain an anti-adhesion gel;

[0041] The anti-adhesion gel is wrapped layer by layer and dried sequentially to obtain an anti-adhesion layer;

[0042] Performing a complexing and crosslinking reaction on the film-forming solution prepared from the second type of absorbable polymer material and a complexing agent to obtain a hemostatic gel;

[0043] The hemostatic gel is formed into a film on the surface of the anti-adhesion layer, and then freeze-dried to obtain the hemostatic and anti-adhesion material.

[0044] In the preparation method provided by the present invention, in the step of preparing the anti-adhesion gel, the first type of absorbable polymer material is prepared into a 2-10% (w / ...

Embodiment 1

[0070] Take the preparation of chitosan-sodium carboxymethyl cellulose / small intestinal mucosa hemostatic and anti-adhesion film as an example.

[0071] Dissolve 2g sodium carboxymethylcellulose in 98g distilled water, stir and dissolve to obtain a 2% (w / w) sodium carboxymethylcellulose solution, then add 0.1% (w / w) 1-ethyl-3-( 3-Dimethylaminopropyl) carbodiimide hydrochloride (EDC), after activating at room temperature for 10 hours, forms a gel, washes repeatedly in ultrapure water for 10 times, and homogenizes;

[0072]The small intestinal mucosa was frozen at -30°C for 16 hours and then thawed at room temperature. Repeated freezing and thawing 3 times, after disinfection, placed in 1M NaCl and 0.5M HCl solution and repeatedly shaken for 10 hours to obtain decellularized small intestine Mucosal sublayer material;

[0073] Place the prepared small intestinal mucosal matrix sublayer material in the sodium carboxymethylcellulose solution for 2 hours, take it out, and leave it ...

Embodiment 2

[0078] Take the preparation of hydroxyethyl cellulose-polylactic acid / peritoneal hemostatic anti-adhesion film as an example.

[0079] After drying 5g of polylactic acid powder at 70°C, dissolve it in 95g of dichloromethane, stir vigorously to obtain a 5% (w / w) polylactic acid solution, and then add 0.8% (w / w) dimethylaminopropyl Ethylcarbodiimide (ETC), after being activated at room temperature for 5 hours to form a gel, placed in ultrapure water for 5 times and then homogenized;

[0080] The pig peritoneum was frozen at -80°C for 24 hours and then thawed at room temperature. Repeated freezing and thawing twice, after disinfection, placed in 0.5M NaCl and 0.1M NaOH solution and repeatedly shaken for 6 hours to obtain pig peritoneum Substratum material;

[0081] The prepared porcine peritoneal sublayer material was placed in the polylactic acid solution for 1 hour, then taken out, and left at room temperature for 1 hour, and this process was repeated 4 times;

[0082] Dissol...

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Abstract

The invention discloses a hemostatic non-viscous material and a preparation method thereof. The material comprises a non-viscous layer of a compact structure, and a hemostatic layer of a loose structure. The non-viscous layer is composed of at least two non-viscous sublayers wrapped up layer by layer. The apertures of small holes in each non-viscous sublayer are of a gradient structure and gradually decrease from outside to inside. The hemostatic layer is also provided with spongy small holes. According to the method, the air-drying, the freeze-drying, the activation and the complexation are conducted respectively. In this way, the non-viscous layer of the compact structure and the hemostatic layer of the loose structure are prepared. Meanwhile, the hemostatic and non-viscous effect of the material is remarkably improved. The material and the method are convenient in clinical application.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a hemostatic and anti-adhesion material and a preparation method thereof. Background technique [0002] Adhesion is a high incidence of clinical complications after surgical operations, especially intestinal adhesions in abdominal and pelvic surgery, uterine adhesions and spinal cord adhesions in spinal surgery, which can easily cause serious complications such as intestinal infarction, pain, secondary infertility, and even life threatening. Adhesions are abnormal structures in which connective tissue fibers join together with adjacent tissues or organs, and can range in size from a fibrous film to a dense vascular scar. [0003] Causes of adhesions include surgical trauma, ischemia, foreign body reactions, bleeding and exposed wound surfaces, and bacterial infection. In order to prevent postoperative adhesions, an anti-adhesion film with excellent compatibility and b...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/00A61L31/14A61B17/12
Inventor 徐宝艳黄文涛刘影乔宝坤刘国强张勇杰
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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