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Pyridine-adamantanamine complex/beta-cyclodextrin inclusion compound, preparation method thereof and application thereof

A technology of cyclodextrin inclusion complex and amantadine is applied in the preparation of organic compounds, preparation of sugar derivatives, organic compounds/hydrides/coordination complex catalysts, etc., and can solve problems such as reduced catalytic hydrolysis cleavage activity

Inactive Publication Date: 2015-09-02
ANHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the activated metal hydroxy compounds produced during the catalytic process are prone to generate metal dimers due to the coordination characteristics of the hydroxyl bridge, which reduces the activity of catalytic hydrolytic cleavage.

Method used

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  • Pyridine-adamantanamine complex/beta-cyclodextrin inclusion compound, preparation method thereof and application thereof
  • Pyridine-adamantanamine complex/beta-cyclodextrin inclusion compound, preparation method thereof and application thereof
  • Pyridine-adamantanamine complex/beta-cyclodextrin inclusion compound, preparation method thereof and application thereof

Examples

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preparation example Construction

[0040]In the preparation method provided by the present invention, the solvent can be selected in a wide range, as long as it can dissolve the reactant, but in order to improve the solvent's dissolving ability, preferably, the solvent includes C1-C3 alcohol and water. In the case where the solvent includes C1-C3 alcohol and water, the amount of each component in the solvent can also be varied within a wide range, but in order to further improve the dissolving power of the solvent, more preferably, with respect to 1 volume part The C1-C3 alcohol, the amount of water is 4-10 parts by weight. Wherein, the C1-C3 alcohol may be methanol, ethanol, n-propanol and isopropanol, but in order to improve the dissolving ability of the solvent again, it is further preferred that the C1-C3 alcohol is ethanol.

[0041] In the preparation method provided by the invention, the specific amount of each raw material can be selected in a wide range, but in order to improve the yield of pyridine-ada...

preparation example 1

[0054] The preparation of the complex of structure shown in formula (IV):

[0055]

[0056] 2.0mmol CuCl 2 , 2.0mmol N,N'-bis(2-pyridylmethyl)amantadine and 20mL ethanol were mixed, then triethylamine was added to adjust the pH of the solution to 7, and reacted at 75°C for 6 hours to obtain a dark blue clear solution. Cool to 25°C, filter, and the filtrate is evaporated to a small amount of solution by rotary evaporation, and left overnight, a large amount of blue solid is precipitated, filtered by suction and dried to obtain a complex with the structure shown in formula (IV).

preparation example 2

[0058] The preparation of the complex of structure shown in formula (V):

[0059]

[0060] According to the method of Preparation Example 1, the difference is that the CuCl 2 Change to ZnCl 2 A complex of the structure shown in formula (V) is obtained.

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Abstract

The invention discloses a pyridine-adamantane amine complex / beta-cyclodextrin inclusion compound, a preparation method thereof and the application thereof. The pyridine-adamantanamine complex / beta-cyclodextrin inclusion compound comprises a structure shown in a formula (I). In the formula (I), an admantyl group is wrapped by beta-cyclodextrin, wherein m and n are a positive integer within the range of 1-4 respectively; M represents a divalent metal positive ion; N1 and N2 represent halogen negative ions; R1 represents a hydrogen atom or a C1-C6 alkyl. According to the technical scheme of the invention, phosphate esters in the nucleic acid can be quickly hydrolyzed by the pyridine-adamantanamine complex / beta-cyclodextrin inclusion compound.

Description

technical field [0001] The invention relates to a pyridine-adamantamine complex / beta-cyclodextrin inclusion complex, a preparation method thereof and an application in catalytic nucleic acid hydrolysis. Background technique [0002] Phosphate plays a vital role in the transmission of genetic information of living organisms, the conduction of cell signals, the transmission of energy and the metabolism of living organisms. The phosphodiester bonds in double-stranded DNA are very stable, with a half-life of 130,000 years from hydrolytic cleavage under physiological conditions. Nucleic acid metabolism in organisms is accomplished by nucleases catalyzing the cleavage of phosphate bonds in nucleic acids. Catalytic nucleic acid cleavage is the core technology of molecular biology and genetic engineering. At present, the reagents for cleavage of the phosphate P-O bond of DNA / RNA mainly include oxidative cleavage reagents based on the redox mechanism (the mechanism is free radical c...

Claims

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Application Information

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IPC IPC(8): B01J31/22C07C205/06C07C201/12C07H1/00
Inventor 周映华刘贤文徐智
Owner ANHUI NORMAL UNIV