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Application of levodopa methyl ester hydrochloride to preparation of drugs for preventing and treating rheumatoid arthritis

A technology of levodopa methyl ester hydrochloride and rheumatoids, which is applied in the field of new drug applications, can solve the problems of LDME relationship that has not yet been studied, and achieve the effect of reducing joint damage, definite curative effect, and improving symptoms

Inactive Publication Date: 2015-09-09
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no research on the relationship between LDME and rheumatoid arthritis, from which the present invention derives

Method used

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  • Application of levodopa methyl ester hydrochloride to preparation of drugs for preventing and treating rheumatoid arthritis
  • Application of levodopa methyl ester hydrochloride to preparation of drugs for preventing and treating rheumatoid arthritis
  • Application of levodopa methyl ester hydrochloride to preparation of drugs for preventing and treating rheumatoid arthritis

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Embodiment 1

[0032]1. Materials and methods

[0033] 1. Materials

[0034] 1.1 Reagents and experimental equipment

[0035] 1.1.1 Main Drugs and Reagents

[0036] Levodopa methyl ester hydrochloride (LDME), dimethyl sulfoxide (DMSO), hydrogen peroxide, ethylenediaminetetraacetic acid disodium salt dihydrate (EDTA) were purchased from Sigma, USA; bovine type II collagen, incomplete IFA and complete Freund's adjuvant (CFA) were purchased from Chondrex, the United States; methanol, hydrochloric acid, glacial acetic acid, ammonia water, absolute ethanol, 95% ethanol, and paraformaldehyde were purchased from Shanghai Feng Chemical Reagent Co., Ltd.; Cole's hematoxylin staining solution (conventional staining) and eosin staining solution were purchased from Beijing Suo Laibao Technology Co., Ltd.; TNF-α, IL-1β, IL-6 enzyme-linked immunosorbent assay kits were purchased from Biosource, the United States.

[0037] 1.1.2 Main Instruments

[0038] Micro-CT (SkyScan 1176, Belgium), paraffin slice...

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Abstract

The invention provides application of levodopa methyl ester hydrochloride to preparation of drugs for preventing and treating rheumatoid arthritis. The chemical structural formula of levodopa methyl ester hydrochloride is shown in the description. The levodopa methyl ester hydrochloride provided by the invention has an exact curative effect on rheumatoid arthritis, so that a powerful basis is provided for developing levodopa methyl ester hydrochloride into a new drug.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and relates to the medicinal use of levodopa methyl hydrochloride, in particular to the application of levodopa methyl hydrochloride in the preparation of medicines for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a common systemic autoimmune disease characterized by chronic, progressive, and erosive arthritis. It mainly affects small joints such as hands, wrists, and feet, and can also affect Such as heart, lungs, nervous system and other organs or tissues. The basic pathological changes of RA are synovial inflammation, pannus formation, and progressive destruction of articular cartilage and bone. Patients may have joint pain, swelling, stiffness and permanent joint destruction at various stages of the disease process. If not controlled in time, it will eventually lead to joint deformity and loss of function, with a high ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P29/00A61P19/02
Inventor 耿德春杨惠林徐耀增邵洪国王熠军
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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