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Method for increasing interface bonding force of HA/ZrO2 layered composite biological ceramic material

A technology of bioceramic materials and composite bioceramics, which is applied in the preparation of bioceramic materials and bio-skeleton materials, can solve the problems of high price, insufficient interface bonding strength, and clinical application limitations, and achieve the effect of low preparation cost

Active Publication Date: 2015-09-09
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many researchers have developed metal-based hydroxyapatite coatings and composite materials, but metal ions are displaced out into the human body in a body fluid environment, which can lead to heavy metal poisoning
Rare metals that are partially inert or harmless to the human body are more expensive, and their clinical application will be limited
[0003] Zirconia (ZrO 2 ) Inert bioceramics have good wear resistance, biocorrosion resistance and biocompatibility, and have the mechanical strength required for bone substitute materials or fixators, but like most of the current bone substitute materials or fixators, it only Can play a pure supporting role, without the biological function of inducing or promoting bone growth
Now the commonly used method for preparing biocomposite ceramics is first dry pressing and then sintering at normal pressure, but due to ZrO 2 The thermal expansion coefficient of HA is nearly twice that of HA, and the thermal expansion coefficient of HA is generally 15×10 -6 K -1 , ZrO 2 The coefficient of thermal expansion is 7.33×10 -6 K -1 , so the problem of insufficient interfacial bonding strength caused by the large difference in shrinkage during cooling limits the HA / ZrO 2 Popularization and application of bioceramics

Method used

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  • Method for increasing interface bonding force of HA/ZrO2 layered composite biological ceramic material
  • Method for increasing interface bonding force of HA/ZrO2 layered composite biological ceramic material
  • Method for increasing interface bonding force of HA/ZrO2 layered composite biological ceramic material

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Comparison scheme
Effect test

Embodiment 1

[0026] In this embodiment, see Figure 1 ~ Figure 4 , A way to improve HA / ZrO 2 The method of interfacial bonding force of layered composite bioceramic material includes the following steps:

[0027] (1) Prepare nano-ZrO by precipitation method respectively 2 And HA powder, put the nano powder in a drying box and dry it completely for later use, nano ZrO 2 See the morphology of powder and nano HA powder figure 1 ;

[0028] (2) Processing such as figure 2 For the pressing mold of the bioceramic wafer sample shown, a boss is processed in the center of the male mold surface of the mold, see image 3 with Figure 4 , Make the surface of the male mold of the mold form a convex pattern, use wire cutting to shape, and polish the surface on a polishing machine to remove burrs. The height of the processed boss is 0.5mm, the diameter is 5mm, and the shape of the boss is Cylinder

[0029] (3) The nano ZrO prepared in step (1) 2 The quality of the powder is determined according to the thickness...

Embodiment 2

[0034] This embodiment is basically the same as the first embodiment, and the special features are:

[0035] In this embodiment, see Figure 5 , A way to improve HA / ZrO 2 The method of interfacial bonding force of layered composite bioceramic material includes the following steps:

[0036] (1) This step is the same as the first embodiment;

[0037] (2) Processing such as figure 2 The pressing mold of the bioceramic disc sample shown, the wave pattern is processed on the male mold surface of the mold, see Figure 5 , Make the wave pattern processed on the male mold surface of the mold have a wavelength of 1mm and an amplitude of 0.5mm, which are formed by wire cutting, and the surface is polished on a polishing machine to remove burrs;

[0038] (3) This step is the same as the first embodiment;

[0039] (4) This step is the same as the first embodiment;

[0040] (5) This step is the same as the first embodiment;

[0041] (6) This step is the same as the first embodiment.

Embodiment 3

[0043] This embodiment is basically the same as the previous embodiment, and the special features are:

[0044] In this embodiment, see Image 6 , A way to improve HA / ZrO 2 The method of interfacial bonding force of layered composite bioceramic material includes the following steps:

[0045] (1) This step is the same as the first embodiment;

[0046] (2) Processing such as figure 2 For the pressing mold of the bioceramic disc sample shown, a grid pattern is processed on the surface of the male mold of the mold. The wavelength of the processed grid pattern is 1mm and the amplitude is 0.5mm, see Figure 5 , When processing the grid pattern on the surface of the male mold, first process the wave pattern on the male mold surface of the mold, and then on the basis of the previous wave pattern, keep the tilt 60 in accordance with the pattern of the previous wave pattern on the male mold surface The second wave pattern is processed again at an angle of °, so that the two processed wave pat...

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Abstract

The invention discloses a method for increasing interface bonding force of a HA / ZrO2 layered composite biological ceramic material. When dry-pressing of a ceramic chip is carried out, a compacting die of a squeeze-film male mould surface with a specific texture structure is employed, the combination surface with the specific texture structure is compacted on a ZrO2 matrix, the formed texture structure comprises boss pattern, groove pattern, tooth saw pattern, wave pattern, intersect pattern or grid pattern; pattern peak height of the texture structure is adapted to the HA thickness size required by HA surface, HA powder paved on the combination surface of the ZrO2 matrix, set moulding pressure is applied for compacting, a biscuit is removed from the die after moulding, and the composite biological ceramic block can be sintered. In the invention, patterns with different texture structures are constructed on the surface of the ZrO2 matrix material, interface contact area of the ZrO2 matrix and HA superficial layer is increased, interface crack expansion length is prolonged, crack expansion direction is changed, so that high interface bonding strength can be obtained.

Description

technical field [0001] The invention relates to a preparation method of a bio-skeleton material, in particular to a preparation method of a bio-ceramic material, which is applied in the technical fields of medical and life-healthy bone substitute materials and fixators. Background technique [0002] Hydroxyapatite (HA or HAP for short), molecular formula Ca 10 (PO 4 ) 6 (OH) 2 , is a bioactive material. The structure of HA is similar to that of natural apatite, and it contains Ca and P elements necessary for human tissues, so it can be applied to artificial bone implants. However, the poor mechanical properties and thermal stability of hydroxyapatite limit its wide clinical application. In order to realize the clinical application of HA, metal substrates coated with HA and HA-based composites came into being. Many researchers have developed metal-based hydroxyapatite coatings and composite materials, but the replacement of metal ions into the human body in a body fluid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/50C04B35/64
Inventor 王春燕韦习成全仁夫李兖锡王武荣
Owner SHANGHAI UNIV