Polysulfone/phosphatide hemodialysis membrane and preparation method thereof

A technology of hemodialysis and dialysis membrane, which is applied in the field of polysulfone/phospholipid hemodialysis membrane and the preparation of the hemodialysis membrane, can solve the problems affecting the filtration effect, etc., and achieve the improvement of filtration efficiency, excellent biocompatibility and high porosity Effect

Inactive Publication Date: 2015-09-09
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Studies have shown that the smaller the diameter of the hollow fiber of the filter material, the better the filtering effect, while the larger diameter of the hollow fiber in the polysulfone membrane prepared by the traditional dry-wet method directly affects the filtering effect. Therefore, a better filter is needed. preparation process to prepare hollow fiber membranes with smaller diameters

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A polysulfone / phospholipid hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.5 μm, the pore diameter is 2.5 μm, and the wall thickness is 60 μm;

[0023] The dialysis membrane is prepared from the following components in parts by mass: 35 parts of polysulfone, 16 parts of phospholipids, 10 parts of polylactic acid, 2 parts of polyether ether ketone, 5 parts of polyvinyl alcohol, 20 parts of dimethylacetamide and 12 parts of acetone.

[0024] A preparation method of polysulfone / phospholipid hemodialysis membrane, the preparation steps are as follows:

[0025] (1) Preparation of spinning solution: add phospholipid, polylactic acid, polyether ether ketone, polyvinyl alcohol and acetone into dimethylacetamide, heat and dissolve in 37°C water bath, and when the solution is transparent, ultrasonically disperse polysulfone in the solution to obtain a spinning solution;

[0026] (2) Electrospinning: electrospin the ...

Embodiment 2

[0030] A polysulfone / phospholipid hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.5 μm, the pore diameter is 2.5 μm, and the wall thickness is 60 μm;

[0031] The dialysis membrane is prepared from the following components in parts by mass: 48 parts of polysulfone, 28 parts of phospholipids, 16 parts of polylactic acid, 5 parts of polyether ether ketone, 10 parts of polyvinyl alcohol, 35 parts of dimethylacetamide and 26 parts of acetone.

[0032] A preparation method of polysulfone / phospholipid hemodialysis membrane, the preparation steps are as follows:

[0033] (1) Preparation of spinning solution: add phospholipid, polylactic acid, polyether ether ketone, polyvinyl alcohol and acetone into dimethylacetamide, heat and dissolve in 37°C water bath, and when the solution is transparent, ultrasonically disperse polysulfone in the solution to obtain a spinning solution;

[0034] (2) Electrospinning: electrospin the...

Embodiment 3

[0038] A polysulfone / phospholipid hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.5 μm, the pore diameter is 2.5 μm, and the wall thickness is 60 μm;

[0039] The dialysis membrane was prepared from the following components in parts by mass: 38 parts of polysulfone, 19 parts of phospholipids, 12 parts of polylactic acid, 3 parts of polyether ether ketone, 6 parts of polyvinyl alcohol, 24 parts of dimethylacetamide and 15 parts of acetone.

[0040] A preparation method of polysulfone / phospholipid hemodialysis membrane, the preparation steps are as follows:

[0041] (1) Preparation of spinning solution: add phospholipid, polylactic acid, polyether ether ketone, polyvinyl alcohol and acetone into dimethylacetamide, heat and dissolve in 37°C water bath, and when the solution is transparent, ultrasonically disperse polysulfone in the solution to obtain a spinning solution;

[0042] (2) Electrospinning: electrospin the...

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Abstract

The invention discloses a polysulfone/phosphatide hemodialysis membrane and a preparation method thereof, which relate to the field of a biological material. The hemodialysis membrane is a hollow fiber membrane comprising hollow fibers, each having a diameter of 0.5-4.5 [mu]m, a pore diameter of 1.2-4.6 [mu]m, and a wall thickness of 50-80 [mu]m. The hemodialysis membrane is prepared from the following components, by mass part: 35-48 of polysulfone, 16-28 of phosphatide, 10-16 of polylactic acid, 2-5 of polyether-ether-ketone, 5-10 of polyvinyl alcohol, 20-35 of dimethyl acetamide, and 12-26 of acetone. The preparation method of the polysulfone/phosphatide hemodialysis membrane comprises the following steps: (1) preparation of a spinning solution; and (2) electrostatic spinning. The polysulfone/phosphatide hemodialysis membrane provided in the invention is excellent in biocompatibility, retention performance, and permeability and is relatively high in filtering efficiency, so that the membrane is a comparatively ideal dialysis membrane material.

Description

technical field [0001] The invention belongs to the field of biological materials, and particularly relates to a polysulfone / phospholipid hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] The hemodialysis membrane uses the principle of semi-permeable membrane and uses the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane to remove toxins and excess water retained in the body, while replenishing the substances needed in the body, and maintaining electrolytes. The purpose of acid-base balance. [0003] Polysulfone membrane dialysis membrane is a synthetic dialysis membrane, which is widely used in the field of hemodialysis because it can effectively remove harmful substances in blood molecules, such as microglobulin and endotoxin. [0004] However, the polysulfone membrane has an impact on its biocompatibility due to its preparation process. Dry and wet spinning process is one ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D69/08B01D67/00A61M1/18
Inventor 李苏杨李文遐徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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