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Antibacterial and anticoagulant polymer material, preparation method and application thereof

A polymer material, anti-coagulation technology, applied in anti-coagulation treatment, transportation and packaging, drug packaging and other directions, can solve the problems of reducing biological activity, inflammatory infection, disappearance, etc., to achieve good comprehensive performance, good antibacterial and anti- The effect of blood coagulation, good function

Active Publication Date: 2015-09-23
BEIJING UNIV OF CHEM TECH +1
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In this method, the anticoagulant is firmly bonded to the surface of the material through covalent bonds, which changes the normal conformation of the anticoagulant, resulting in the possibility of embedding or destroying the active part with anticoagulant function, thus reducing the Its biological activity is reduced, and the anticoagulant effect is reduced to varying degrees, and some even disappear completely, losing clinical application significance.
Therefore, there is still no report that can directly graft anticoagulant on the surface of polymer matrix material and obtain good anticoagulant effect.
[0007] In addition, in clinical applications, due to factors such as the special environment of the hospital, anticoagulant biomaterials are prone to infection. On the one hand, the introduction of foreign substances can stimulate the proliferation of Staphylococcus aureus in the body, thereby causing inflammation and infection; Cause In the hospital environment, the spread of bacteria through the clothing, gloves and items in the hospital of medical staff can easily lead to infection

Method used

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  • Antibacterial and anticoagulant polymer material, preparation method and application thereof
  • Antibacterial and anticoagulant polymer material, preparation method and application thereof
  • Antibacterial and anticoagulant polymer material, preparation method and application thereof

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preparation example Construction

[0027] In the preparation method of the antibacterial and anticoagulant polymer material of the present invention, there is no special limitation on the method of mixing the materials containing polymer matrix material, nitric oxide donor substance, hydrophilic material and antibacterial agent, For example, a melt kneading method may be used. The present invention has no special limitation on the mixing conditions, and various mixing methods in the prior art can be used in the present invention. For example, mixing can be performed on extruders, open mills and internal mixers. From the perspective of product performance, preferably, the kneading conditions may include: a kneading temperature of 20-400° C.; a kneading time of 2 minutes to 2 hours.

[0028] According to the present invention, in the embodiment where the mixing is carried out in an extruder, the rotating speed of the extruder can be selected according to the type of polymer matrix material, specifically, the rot...

Embodiment 1

[0050] 1. 20g S-nitrosoglutathione (Suzhou Yake Chemical Reagent Co., Ltd., Mw: 335.3), 30g nano-titanium dioxide (obtained by Hangzhou Wanjing New Material Co., Ltd., trade name VK-TA18S) and 20g polyethyleneimine (Sinopharm Chemical Reagent Beijing Co., Ltd., Mw: 7000, M W / M n =2.5) Add 300ml of ethanol, stir well at 40°C for 30 minutes to mix evenly, then ultrasonically disperse at 60°C (ultrasonic power is 1600W) for 30 minutes, and finally dry under reduced pressure at 40°C and 0.08MPa to constant weight. spare.

[0051] 2. get the mixture that 100g polyether polyurethane (BASF, trade mark is E1195A) and 70g step 1) prepare through extruder mixing, the screw speed of extruder is 600 rev / mins, 250 ℃ of mixing temperatures, extrude After being granulated, the antibacterial and anticoagulant polymer material is obtained.

[0052] The static platelet adhesion scanning electron micrograph in vitro of the polyether polyurethane (matrix material) used in this embodiment is s...

Embodiment 2

[0055] 1. 10g S-nitroso serum albumin (Shanghai Times Biotechnology Co., Ltd., grade: BR, total protein content: ≥95.0% by weight), 10g chitosan (Shanghai Boao Biotechnology Co., Ltd., weight average molecular weight 15000, light yellow powder, deacetylation degree ≥ 90%) and 5g of polyethylene glycol (Beijing Lanli Fine Chemicals, weight average molecular weight: 400) were added to 100ml of ethanol, fully stirred at 25°C for 100 minutes to mix evenly, and then Ultrasonic disperse at 25°C (ultrasonic power is 1600W) for 60 minutes, and finally dry under reduced pressure at 40°C and 0.08MPa to constant weight for future use.

[0056] 2. get the mixture that 100g polypropylene (Japan C hours ISSO company, trade mark XF1800) and 25g step 1) prepare through extruder mixing, the screw speed of extruder is 400 rev / mins, mixing temperature 220 ℃ , and then granulated to obtain an antibacterial and anticoagulant polymer material.

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Abstract

The invention relates to an antibacterial and anticoagulant polymer material, a preparation method and applications thereof. The polymer material comprises the following components in parts by weight: 100 parts of polymer base material, 1 to 30 parts of nitrogen monoxide donor material, 1 to 35 parts of antibacterial agent, and 1 to 35 parts of hydrophilic material. The provided polymer material has the antibacterial and anticoagulant functions, and thus is especially suitable for being used as a medical polymer material. The invention also relates to a preparation method and an application of the polymer material as a medical antibacterial and anticoagulant polymer material.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and in particular relates to an antibacterial and anticoagulant polymer material and its preparation method and application. The antibacterial and anticoagulant polymer material can be used as a medical polymer material. Background technique [0002] Biomaterials are a class of materials that can be used for repair and replacement of animal organs and tissues, diagnosis and treatment of diseases, and are biocompatible with animals and have special properties or functions. Antibacterial and anticoagulant biomaterials are an important part of biomaterials, and are widely used in medical materials in contact with human blood and tissues, such as hemodialysis systems, extracorporeal circulation systems, artificial heart valves, cardiac pacemakers, artificial blood vessels , vascular stents, surgical lines and catheters, etc. With the development of the population aging process, the number...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L75/08C08L27/18C08L29/04C08L83/04C08L67/00C08L77/00C08L33/12C08L27/06C08L23/06C08L23/12C08L25/06C08L71/08C08L67/04C08L81/06A61L33/00A61L33/04A61L33/12A61L33/08
Inventor 丁雪佳庞凯敏刘燕琴张龙朱杰克王国胜魏永飞范义峰
Owner BEIJING UNIV OF CHEM TECH
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