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Microporous chitosan oligosaccharide/sodium alginate hemostasis granule and preparation method thereof

A technology of sodium alginate and hemostatic granules is applied in the field of biomedical technical materials, which can solve the problems of high cost, complicated process, unenvironmental protection and the like, and achieve the effects of better effect, good biocompatibility and good application prospect.

Inactive Publication Date: 2015-09-30
上海长欧生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing preparation methods have disadvantages such as complex process, high cost, and environmental protection

Method used

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  • Microporous chitosan oligosaccharide/sodium alginate hemostasis granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Get 1470 grams of chitosan oligosaccharide powder, 1500 grams of sodium alginate and 30 grams of calcium chloride, crush at high speed, pass through a 500-mesh sieve, and set aside;

[0028] (2) Heat the inlet air temperature of the fluidized granulator to 90°C, pour the chitosan oligosaccharide powder, sodium alginate powder, and calcium chloride powder obtained in step (1) into the fluidized granulator, and boil and mix with hot air for 5 minutes. Fully mix the raw materials, and control the internal temperature of the granulator at 50°C;

[0029] (3) Prepare 1.5wt% cellulose sodium salt solution, pass through an 80-mesh sieve to obtain a binder; then connect a peristaltic pump, and spray the binder into the granulator;

[0030] (4) After 30 minutes, observe the granulation situation, take a sample through a 40 / 150 mesh sieve, and observe whether it meets the standard; after the granulation reaches the standard, stop the peristaltic pump, dry it with hot air for 5...

Embodiment 2

[0032] (1) Get 1800 grams of chitosan oligosaccharides, 1170 grams of sodium alginate and 30 grams of calcium chloride, pulverize at a high speed, pass through a 500-mesh sieve, and set aside;

[0033] (2) Heat the inlet air temperature of the fluidized granulator to 80°C, pour the chitosan oligosaccharide powder, sodium alginate powder, and calcium chloride powder obtained in step (1) into the fluidized granulator, and boil and mix with hot air for 5 minutes. Fully mix the raw materials, and control the internal temperature of the granulator at 50°C;

[0034] (3) Prepare 2wt% sodium alginate solution, pass through an 80-mesh sieve to obtain a binder; then connect a peristaltic pump, and spray the binder into the granulator;

[0035] (4) After 30 minutes, observe the granulation situation, take a sample through a 40 / 150 mesh sieve, and observe whether it meets the standard; after the granulation reaches the standard, stop the peristaltic pump, dry it with hot air for 5 minutes...

Embodiment 3

[0037] (1) Get 1000 grams of chitosan oligosaccharide, 1970 grams of sodium alginate and 30 grams of calcium chloride, pulverize at a high speed, pass through a 500-mesh sieve, and set aside;

[0038] (2) Heat the inlet air temperature of the fluidized granulator to 90°C, pour the chitosan oligosaccharide powder, sodium alginate powder, and calcium chloride powder obtained in step (1) into the fluidized granulator, and boil and mix with hot air for 5 minutes. Fully mix the raw materials, and control the internal temperature of the granulator at 60°C;

[0039] (3) Prepare 1.5wt% sodium alginate solution, pass through a 80-mesh sieve to obtain a binder; then connect a peristaltic pump, and spray the binder into the granulator;

[0040](4) After 30 minutes, observe the granulation situation, take a sample through a 40 / 150 mesh sieve, and observe whether it meets the standard; after the granulation reaches the standard, stop the peristaltic pump, dry it with hot air for 5 minutes,...

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Abstract

The invention relates to a microporous chitosan oligosaccharide / sodium alginate hemostasis granule and a preparation method thereof. The hemostasis granule comprises a plurality of loose powder granules, wherein a plurality of micropores or gaps are formed among the powder granules. The preparation method comprises the steps that (1) chitosan oligosaccharide, sodium alginate and calcium chloride are taken, crushed and sieved for standby; (2) mixing is performed via a boiling granulator; (3) an adhesive is prepared; a peristaltic pump is connected; the adhesive is sprayed into the granulator; and (4) granulation is observed; sampling and sieving are performed; whether the granulation reaches a standard is observed; the peristaltic pump is stopped after the granulation reaches the standard; hot air drying is performed; shutdown is performed; a material is taken out and sieved; the qualified material is a finished product; and sterilization and packaging are performed. The hemostasis granule has good biocompatibility, can be absorbed by a human body, does not cause toxic or side effects such as allergy and poisoning, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical technical materials, in particular to a microporous chitosan / sodium alginate hemostatic particle and a preparation method thereof. Background technique [0002] Whether it is a bloody war conflict or disaster accidents such as earthquakes, explosions, and traffic accidents, bleeding is the main cause of death before the hospital. Rapid and effective control of bleeding can significantly reduce deaths due to bleeding. According to the experience in previous wars, the number of dead accounts for 20% of the number of wounded, of which 90% are pre-hospital deaths. Immediate and effective field hemostasis can reduce the mortality rate by more than 20%. With the extensive use of high-speed and high-energy explosive weapons in modern warfare, the resulting tissue damage is more extensive, the pollution is heavier, the bleeding is more, and the mortality rate is higher. Simple, rapid and effective hemostasis ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/60A61L15/44
Inventor 陈红吴彪杨峰
Owner 上海长欧生物科技有限公司
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