Microporous chitosan oligosaccharide/sodium alginate hemostasis granule and preparation method thereof

Abstract

The invention relates to a microporous chitosan oligosaccharide / sodium alginate hemostasis granule and a preparation method thereof. The hemostasis granule comprises a plurality of loose powder granules, wherein a plurality of micropores or gaps are formed among the powder granules. The preparation method comprises the steps that (1) chitosan oligosaccharide, sodium alginate and calcium chloride are taken, crushed and sieved for standby; (2) mixing is performed via a boiling granulator; (3) an adhesive is prepared; a peristaltic pump is connected; the adhesive is sprayed into the granulator; and (4) granulation is observed; sampling and sieving are performed; whether the granulation reaches a standard is observed; the peristaltic pump is stopped after the granulation reaches the standard; hot air drying is performed; shutdown is performed; a material is taken out and sieved; the qualified material is a finished product; and sterilization and packaging are performed. The hemostasis granule has good biocompatibility, can be absorbed by a human body, does not cause toxic or side effects such as allergy and poisoning, and has a good application prospect.

Description

technical field

[0001] The invention belongs to the field of biomedical technical materials, in particular to a microporous chitosan / sodium alginate hemostatic particle and a preparation method thereof. Background technique

[0002] Whether it is a bloody war conflict or disaster accidents such as earthquakes, explosions, and traffic accidents, bleeding is the main cause of death before the hospital. Rapid and effective control of bleeding can significantly reduce deaths due to bleeding. According to the experience in previous wars, the number of dead accounts for 20% of the number of wounded, of which 90% are pre-hospital deaths. Immediate and effective field hemostasis can reduce the mortality rate by more than 20%. With the extensive use of high-speed and high-energy explosive weapons in modern warfare, the resulting tissue damage is more extensive, the pollution is heavier, the bleeding is more, and the mortality rate is higher. Simple, rapid and effective hemostasis ...

Images