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Preparation method of hydroxyapatite microspheres

A technology of hydroxyapatite and microspheres, which is applied in the field of preparation of hydroxyapatite microspheres, can solve problems such as difficult industrial production line layout, increased production costs, and poor application effects, achieving high yield, rapid response, The effect of mild reaction conditions

Inactive Publication Date: 2017-05-31
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The applicant conducted laboratory research and small-scale industrial production on this scheme in the early stage, and found that it has relatively strict requirements on the temperature of the entire reaction, and it is necessary to control the temperature in sections of 40-60°C and 160°C in the entire production line, which is difficult The arrangement on the industrial production line greatly increases the production cost; at the same time, this method combines the preparation of hydroxyapatite and microspheroidization into one production process. Since the control of different raw materials will affect the final process effect, this method is difficult to control Product yield, it is easy to leave the initial raw materials in the microspheres, resulting in poor application effect

Method used

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  • Preparation method of hydroxyapatite microspheres
  • Preparation method of hydroxyapatite microspheres
  • Preparation method of hydroxyapatite microspheres

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Experimental program
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Effect test

Embodiment 1

[0027] (1) 2.8416g of anhydrous calcium chloride and 2.1808g of disodium hydrogen phosphate were dissolved in 40ml of deionized water respectively, the calcium solution was added into the phosphorus solution, stirred for 30min, transferred to a polytetrafluoroethylene reactor, sealed, and heated at 180 ℃ water heating for 10h. Cool at room temperature, centrifuge, wash with deionized water, and dry at 60°C for 24 hours to obtain hydroxyapatite.

[0028] (2) Weigh 0.502 g of the above-mentioned hydroxyapatite and add it into 500 ml of deionized water, slowly add hydrochloric acid with a concentration of 1 mol / L dropwise while stirring until the hydroxyapatite is completely dissolved.

[0029] (3) Add 0.0871 g of arginine powder to the above solution, and stir at room temperature for 10 min.

[0030] (4) Place the obtained solution and ammonia water in a closed reactor for reaction, and the reaction time is 0.5-7 days.

[0031] (5) Centrifugally filter the solution obtained in...

Embodiment 2

[0035] (1) Dissolve 2.8416g of anhydrous calcium chloride and 2.1808g of disodium hydrogen phosphate in 40ml of deionized water respectively, add the calcium solution into the phosphorus solution, stir for 30min, transfer to a polytetrafluoroethylene reactor, seal it, and store it at 180°C Water heat 10h. Cool at room temperature, centrifuge, wash with deionized water, and dry at 60°C for 24 hours to obtain hydroxyapatite.

[0036] (2) Weigh 0.502 g of the above-mentioned hydroxyapatite and add it into 500 ml of deionized water, slowly add hydrochloric acid with a concentration of 1 mol / L dropwise while stirring until the hydroxyapatite is completely dissolved.

[0037] (3) Add 0.0586g of valine powder to the above solution, and stir at room temperature for 10min.

[0038] (4) Place the obtained solution and ammonia water in a closed reactor for reaction, and the reaction time is 0.5-7 days.

[0039] (5) Centrifugally filter the solution obtained in step (4), and rinse with ...

Embodiment 3

[0043] (1) Dissolve 2.8416g of anhydrous calcium chloride and 2.1808g of disodium hydrogen phosphate in 40ml of deionized water respectively, add the calcium solution into the phosphorus solution, stir for 30min, transfer to a polytetrafluoroethylene reactor, seal it, and store it at 180°C Water heat 10h. Cool at room temperature, centrifuge, wash with deionized water, and dry at 60°C for 24 hours to obtain hydroxyapatite.

[0044] (2) Weigh 0.502 g of the above-mentioned hydroxyapatite and add it into 500 ml of deionized water, slowly add hydrochloric acid with a concentration of 1 mol / L dropwise while stirring until the hydroxyapatite is completely dissolved.

[0045] (3) Add 0.0525 g of powder to the above solution, and stir at room temperature for 10 min.

[0046] (4) Place the obtained solution and ammonia water in a closed reactor for reaction, and the reaction time is 0.5-7 days.

[0047] (5) Centrifugally filter the solution obtained in step (4), and rinse with deion...

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Abstract

The invention discloses a preparation method for hydroxyapatite microspheres. The preparation method comprises the following steps: hydroxyapatite reacts in an acid environment by taking amino acid as an additive, and the pH value of a solution is changed through ammonia diffusion to be 8-10. In the preparation method, disclosed by the invention, the amino acid is taken as the additive, and ammonia is taken as a pH regulator; the preparation process is simplified, the additive does not need to be removed specially, and pollution of additive residues to a final sample is also avoided; besides, the hydroxyapatite microspheres, prepared according to the preparation method, is high in specific surface area and suitable for being applied to biological drug loading.

Description

technical field [0001] The invention discloses a preparation method of hydroxyapatite microspheres, belonging to the field of inorganic biomedical materials. Background technique [0002] The molecular formula of hydroxyapatite (HA or HAP) is Ca 10 (PO 4 ) 6 (OH) 2 , with a density of 3.16g / cm 3 . Slightly soluble in water, weakly alkaline, easily soluble in acid, hardly soluble in alkali. HA is an important inorganic component in human bones and teeth, accounting for more than 75% of human bone tissue. Because of its good biocompatibility, osteoconductivity, fluidity and adsorption, it is widely used in bone tissue engineering technology and so on. In recent years, in order to meet different application requirements, researchers have prepared hydroxyapatite materials in various forms such as spherical, rod, flake, and whisker. Among these morphologies, spherical hydroxyapatite has attracted great attention because of its advantages such as good fluidity, high specif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32
Inventor 沈娟齐永成金波
Owner SOUTHWEAT UNIV OF SCI & TECH