Blood heavy metal ion adsorbent, preparation method thereof and blood perfusion device

Abstract

The invention discloses a blood heavy metal ion adsorbent. With magnetic nano materials being carriers, the surfaces of the carriers are wrapped with ligand active groups in a modification mode, wherein the ligand active groups are capable of being combined with heavy metal ions and coordination compounds. The magnetic nano materials are magnetic iron-based compounds MFe2O4, wherein M is Fe2+ or Co2+ or Ni2+ or Zn2+ or Mg2+. The ligand active groups are one or more of -NH2, -SH2, -COOH and -OH. The invention further provides a preparation method of the blood heavy metal ion adsorbent and a blood perfusion device made from the blood heavy metal ion adsorbent. The surfaces of the magnetic nano-particles are modified, so that the blood heavy metal ion adsorbent is obtained and used for performing efficient selective or specific adsorption on one kind of heavy metal, it is avoided that because non-specific adsorption is performed on microelements in blood, the protein denatures and becomes inactive, and influences on the blood by the adsorbent and the risk of organism systematic complications are greatly reduced.

Description

technical field [0001] The invention belongs to the field of medical materials, and relates to a blood heavy metal adsorbent, a preparation method thereof and a hemoperfusion device. Background technique [0002] Heavy metal elements refer to specific density greater than 5g / cm 2 Metal elements such as lead (Pb), cadmium (Cd), mercury (Hg), chromium (Cr), arsenic (As), thallium (Ta), etc., they widely exist in the earth's crust, and the body has only a very low concentration. Heavy metals in the atmosphere, soil, and water, even in trace amounts, can cause serious problems for all organisms. Over the past 10 years, with the continuous acceleration of China's industrialization, more and more industries are involved in heavy metal emissions. Excessive heavy metal ion emissions cause environmental pollution. Through biological migration, tissue concentration, bioaccumulation and biomagnification, they are in the biological chain The health of human beings at the end is bound ...

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Problems solved by technology

However, most of the above-mentioned adsorption materials are large-particle porous materials. Compared with nano-materials, their specific surface area is small, and the active groups grafted on the surface are relatively few. At the same time, it is absorbed and removed, causing systemic complications in the body, and most of them are disposable materials, which are expensive

Inorganic material adsorbents mainly include macroporous silica gel and porous glass, but due to poor biocompatibility with proteins, the price is relatively expensive, there are few surface active groups, and acidic silanol groups remain on the surface of the adsorbent, resulting in non-specific adsorption and limited applications.

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