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Preparation method of N-lauroyl-L-alanine saline solution with low inorganic salt content

A technology of lauroyl alanine salt and inorganic salt, which is applied in the field of preparation of lauroyl alanine salt solution, can solve the problems of time-consuming operation, quality such as low temperature stability, transparency, and paste-forming ability, which greatly affects product application. performance and other issues to achieve cost savings

Inactive Publication Date: 2015-10-28
GUANGZHOU TINCI MATERIALS TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water / ethanol mixed phase preparation process will produce ethyl ester by-products in the liquid separation process of the post-treatment, which will greatly affect the application performance of the product.
In addition, the lauroylalanine salt obtained by the existing technology is usually a liquid product, its solid content is usually about 30%, and its inorganic salt content is usually higher than 1%, which has a negative impact on the quality of the product such as low temperature stability, transparency, structure, etc. Ointment ability, etc. have a great influence
For this reason people are devoted to seeking the industrialized preparation method of high-purity lauroyl glutamate, try to obtain by the method for recrystallization, but operation is time-consuming, and can only obtain acid products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of preparation method of the lauroyl alanine salt solution of present embodiment low inorganic salt content, comprises the steps:

[0025] (1) Reaction stage: at room temperature, in a 1L four-necked flask, disperse 48.2g of alanine in 300mL of deionized water, add dropwise 32% NaOH to adjust the pH of the system to 11-12, then add 150mL of ethanol and stir evenly; The temperature is controlled at 20±1°C, while the pH is 11-12, and 91.2g of lauroyl chloride is added dropwise evenly and slowly within 1.5-2 hours. During the dropping process, the pH is controlled at 11-12, and the temperature is 20±1°C. After the acid chloride was dripped, the reaction was continued for 45 min to obtain a clear solution.

[0026] (2) Separation stage: stop the reaction, start to heat up and acidify to pH 2.5-3.0 with 6N hydrochloric acid at the same time, control the temperature at 55-60°C and stir vigorously for 10 minutes, then let it stand still, remove the water layer after 10 ...

Embodiment 2

[0030] A kind of preparation method of the lauroyl alanine salt solution of present embodiment low inorganic salt content, comprises the steps:

[0031] (1) Reaction stage: at room temperature, in a 1L four-necked flask, disperse 48.2g of alanine in 300mL of deionized water, add dropwise 32% NaOH to adjust the pH of the system to 11-12, then add 150mL of ethanol and stir evenly; The temperature is controlled at 20±1°C, while the pH is 11-12, and 91.2g of lauroyl chloride is added dropwise evenly and slowly within 1.5-2 hours. During the dropping process, the pH is controlled at 11-12, and the temperature is 20±1°C. After the acid chloride was dripped, the reaction was continued for 45 min to obtain a clear solution.

[0032] (2) Separation stage: stop the reaction, start to heat up and acidify to pH 2.5-3.0 with 6N hydrochloric acid at the same time, control the temperature at 55-60°C and stir vigorously for 10 minutes, then let it stand still, remove the water layer after 10 ...

Embodiment 3

[0036] A kind of preparation method of the lauroyl alanine salt solution of present embodiment low inorganic salt content, comprises the steps:

[0037] (1) Reaction stage: at room temperature, in a 1L four-necked flask, disperse 48.2g of alanine in 300mL of deionized water, add dropwise 32% NaOH to adjust the pH of the system to 11-12, then add 150mL of ethanol and stir evenly; The temperature is controlled at 20±1°C, while the pH is 11-12, and 91.2g of lauroyl chloride is added dropwise evenly and slowly within 1.5-2 hours. During the dropping process, the pH is controlled at 11-12, and the temperature is 20±1°C. After the acid chloride was dripped, the reaction was continued for 45 min to obtain a clear solution.

[0038](2) Separation stage: stop the reaction, start to heat up and acidify to pH 2.5-3.0 with 6N hydrochloric acid at the same time, control the temperature at 55-60°C and stir vigorously for 10 minutes, then let it stand still, remove the water layer after 10 m...

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Abstract

The invention discloses a preparation method of N-lauroyl-L-alanine saline solution with low inorganic salt content. The method comprises a reacting step, a separating step, a desolventizing step and a neutralizing step. According to the invention, after reaction, the separating frequency and the separating technological parameters can be controlled for obtaining the end-product with low inorganic salt content, and the content of ethyl ester by-products in the N-lauroyl-L-alanine saline solution is lower than 0.1%.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a preparation method of lauroyl alanine salt solution with low inorganic salt content. Background technique [0002] Sodium lauroylalanine is a new type of surfactant. Its pH value is close to neutral and slightly acidic, which is very close to the pH value of human skin. It can make the skin feel comfortable and soft, with low toxicity and no irritation. It is used as a raw material for personal care washing products and daily cosmetics, and the effect is very good. It has the characteristics of antistatic, bactericidal, good compatibility, and hard water resistance under acidic conditions, and can be widely used in various liquids, creams, facial cleansers, masks, skin care products, toothpaste, washing products, shampoo, bath It is very suitable for formulating non-sulfate system formulations in daily chemical products such as lotion and various soaps, especially s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/47C07C231/02
Inventor 李泽勇陈磊雷秋芬刘雅婷宋吾燕
Owner GUANGZHOU TINCI MATERIALS TECH
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