Non-addiction local anesthesia analgesic sustained-release drug delivery system and method for preparing same

A drug delivery system and non-addictive technology, applied in the field of pharmacy, can solve the problems of insignificant analgesic effect and large side effects of analgesics, and achieve the effects of long analgesic duration, reduced side effects, and enhanced therapeutic effect

Inactive Publication Date: 2015-11-11
GUANGZHOU JINZHONGJIAN MEDICAL EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the defects of large side effects and insignificant analgesic effect of postoperative analgesics in the prior art, the object of the present

Method used

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  • Non-addiction local anesthesia analgesic sustained-release drug delivery system and method for preparing same
  • Non-addiction local anesthesia analgesic sustained-release drug delivery system and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, Preparation of Non-addictive Local Anesthesia Analgesic Sustained Release Injection

[0023] Composition of Non-addictive Local Analgesic Analgesic Sustained Release Injection:

[0024] Bupivacaine Free Base 30mg

[0025] Morphine 1mg

[0026] Ethanol 0.3ml

[0027] Add soybean oil to 10ml

[0028] Its preparation method comprises the following steps:

[0029] Weigh bupivacaine free base and morphine, add ethanol, vortex to fully dissolve, slowly add soybean oil to the drug solution to 10ml, vortex to mix, remove impurities and bacteria by membrane filtration, and pack into ampoules Make injections, seal and pass the light inspection, and pack.

Embodiment 2

[0030] Embodiment 2, Preparation of Non-addictive Local Anesthesia Analgesic Sustained Release Injection

[0031] Composition of Non-addictive Local Analgesic Analgesic Sustained Release Injection:

[0032] Bupivacaine Hydrochloride 40mg

[0033] Morphine 1mg

[0034] Benzyl Benzoate 0.4ml

[0035] Add ethyl oleate to 10ml

[0036] Its preparation method comprises the following steps:

[0037] Weigh bupivacaine hydrochloride and morphine, add benzyl benzoate, vortex to fully dissolve, slowly add ethyl oleate to the drug solution to 10ml, vortex to mix, remove impurities and bacteria by membrane filtration, Subpackage into ampoules to make injections, seal and pass the light inspection, and pack.

Embodiment 3

[0038] Embodiment 3, Preparation of Non-addictive Local Anesthesia Analgesic Sustained Release Injection

[0039] Composition of Non-addictive Local Analgesic Analgesic Sustained Release Injection:

[0040] Bupivacaine Free Base 70mg

[0041] Morphine 2mg

[0042] Benzyl alcohol 0.3ml

[0043] Add ethyl oleate to 10ml

[0044] Its preparation method comprises the following steps:

[0045] Weigh bupivacaine free base and morphine, add benzyl alcohol, vortex to fully dissolve, slowly add ethyl oleate to the drug solution to 10ml, vortex to mix, remove impurities and bacteria by membrane filtration, and separate Pack into ampoules to make injections, seal and pass the light inspection, and pack.

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Abstract

The invention belongs to the field of pharmacy, and mainly relates to a non-addiction local anesthesia analgesic sustained-release drug delivery system and a method for preparing the same. The sustained-release drug delivery system comprises analgesics, solvents and sustained-release preparations. The analgesics are compositions of bupivacaine free alkali or bupivacaine salts and morphine; the solvents are one or two of ethyl alcohol, benzyl alcohol, benzyl benzoate, ethyl lactate and tetrahydrofuran polyglycol ether; the sustained-release preparations are one or two of soybean oil, ethyl oleate and castor oil. The non-addiction local anesthesia analgesic sustained-release drug delivery system and the method have the advantages that the non-addiction local anesthesia analgesic sustained-release drug delivery system is free of addiction, long in analgesic duration time and low in toxicity, obvious analgesic effects can be realized, and only few side effects can be realized; the non-addiction local anesthesia analgesic sustained-release drug delivery system is free of human tissue irritation and influence on healing of postoperative wound, and obvious local anesthesia analgesic treatment effects can be realized for the postoperative wound.

Description

technical field [0001] The invention belongs to the field of pharmacy, and mainly relates to a non-addictive local anesthesia analgesic sustained-release drug delivery system and a preparation method thereof. Background technique [0002] Postoperative pain is a complex physiological response of the body to the disease itself and surgical trauma, and it is a kind of acute pain. Postoperative pain is divided into body pain and visceral pain. Body pain refers to the parts directly affected by the operation, such as skin, muscle, fascia, joints, ligaments, bones, and nerves. Pain in superficial wounds. Body pain is visceral pain caused by visceral surgery or traction to viscera, and is generally deep and dull pain, and its pain intensity is related to the sensitivity of viscera. Although the duration of postoperative pain is short, the pain is severe, which seriously affects the functions of various systems of the patient, and can also cause some serious complications, especi...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K9/08A61K9/12A61K47/44A61K47/14A61P23/02A61P29/00A61K31/445
Inventor 莫淑渟
Owner GUANGZHOU JINZHONGJIAN MEDICAL EQUIP CO LTD
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