Non-addiction local anesthesia analgesic sustained-release drug delivery system and method for preparing same
A drug delivery system and non-addictive technology, applied in the field of pharmacy, can solve the problems of insignificant analgesic effect and large side effects of analgesics, and achieve the effects of long analgesic duration, reduced side effects, and enhanced therapeutic effect
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Embodiment 1
[0022] Embodiment 1, Preparation of Non-addictive Local Anesthesia Analgesic Sustained Release Injection
[0023] Composition of Non-addictive Local Analgesic Analgesic Sustained Release Injection:
[0024] Bupivacaine Free Base 30mg
[0025] Morphine 1mg
[0026] Ethanol 0.3ml
[0027] Add soybean oil to 10ml
[0028] Its preparation method comprises the following steps:
[0029] Weigh bupivacaine free base and morphine, add ethanol, vortex to fully dissolve, slowly add soybean oil to the drug solution to 10ml, vortex to mix, remove impurities and bacteria by membrane filtration, and pack into ampoules Make injections, seal and pass the light inspection, and pack.
Embodiment 2
[0030] Embodiment 2, Preparation of Non-addictive Local Anesthesia Analgesic Sustained Release Injection
[0031] Composition of Non-addictive Local Analgesic Analgesic Sustained Release Injection:
[0032] Bupivacaine Hydrochloride 40mg
[0033] Morphine 1mg
[0034] Benzyl Benzoate 0.4ml
[0035] Add ethyl oleate to 10ml
[0036] Its preparation method comprises the following steps:
[0037] Weigh bupivacaine hydrochloride and morphine, add benzyl benzoate, vortex to fully dissolve, slowly add ethyl oleate to the drug solution to 10ml, vortex to mix, remove impurities and bacteria by membrane filtration, Subpackage into ampoules to make injections, seal and pass the light inspection, and pack.
Embodiment 3
[0038] Embodiment 3, Preparation of Non-addictive Local Anesthesia Analgesic Sustained Release Injection
[0039] Composition of Non-addictive Local Analgesic Analgesic Sustained Release Injection:
[0040] Bupivacaine Free Base 70mg
[0041] Morphine 2mg
[0042] Benzyl alcohol 0.3ml
[0043] Add ethyl oleate to 10ml
[0044] Its preparation method comprises the following steps:
[0045] Weigh bupivacaine free base and morphine, add benzyl alcohol, vortex to fully dissolve, slowly add ethyl oleate to the drug solution to 10ml, vortex to mix, remove impurities and bacteria by membrane filtration, and separate Pack into ampoules to make injections, seal and pass the light inspection, and pack.
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