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Transfer factor and application thereof

A technology of transfer factor and spleen, applied in the field of immune promotion, can solve the problem of low product yield, and achieve the effects of enhancing immune function, reducing production temperature and improving treatment rate

Inactive Publication Date: 2015-11-11
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides a transfer factor characterized by a method, so as to solve the technical problem that the product yield of the transfer factor preparation method of the prior art is low

Method used

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  • Transfer factor and application thereof
  • Transfer factor and application thereof
  • Transfer factor and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Preparation of Transfer Factor Oral Liquid

[0036] (1) Pick up 40kg of material according to the production plan, and enter the production area to remove the outer packaging;

[0037] (2) Coarsely grind according to the operating procedures of the frozen meat grinder, coarsely grind the frozen meat, add 0.4 times of purified water to mix, and stir into a fluid state;

[0038] (3) Fine stranding: According to the operating procedures of the colloid mill, the colloid mill grinds the coarse strand liquid 2 to 3 times, and harvests 55 kg of the fine strand liquid;

[0039] (4) Centrifugal fine strand liquid is diluted with raw material: purified water=1:1.5 ratio plus purified water, stir well, harvest 97kg dilution, remove large fascia through centrifuge (60 mesh sieves), harvest fine strand liquid 88kg;

[0040] (5) After the cell is broken and centrifuged, the fine strand liquid is broken by a high-pressure homogenizer (75MPa), and 87kg of the homogenized liquid is ...

Embodiment 2

[0068] A transfer factor prepared by the following method:

[0069] 1) taking animal spleen, mincing it to obtain spleen homogenate;

[0070] 2) taking the spleen homogenate described in step 1) for solid-liquid separation, and taking the supernatant;

[0071] 3) take the supernatant described in step 2) and break it homogeneously, and collect the homogeneous liquid;

[0072] 4) Take the homogeneous liquid described in step 3) for solid-liquid separation, and take the supernatant;

[0073] 5) Take the supernatant described in step 4) for ultrafiltration, and collect the permeate.

[0074] On the basis of the above technical solutions, the following conditions are met:

[0075] The mincing described in step 1) is first crushed once with a meat crushing device, then mixed with purified water 0.2 times the weight of the raw material of the spleen, and then ground twice with a colloid mill, and then added 0.9 times the weight of the raw material of the spleen Purified water wa...

Embodiment 3

[0085] A transfer factor prepared by the following method:

[0086] 1) taking animal spleen, mincing it to obtain spleen homogenate;

[0087] 2) taking the spleen homogenate described in step 1) for solid-liquid separation, and taking the supernatant;

[0088] 3) take the supernatant described in step 2) and break it homogeneously, and collect the homogeneous liquid;

[0089] 4) Take the homogeneous liquid described in step 3) for solid-liquid separation, and take the supernatant;

[0090] 5) Take the supernatant described in step 4) for ultrafiltration, and collect the permeate.

[0091] On the basis of the above technical solutions, the following conditions are met:

[0092] The mincing described in step 1) is first crushed with a meat crushing device, then mixed with purified water 0.6 times the weight of the spleen raw material, then ground with a colloid mill, and then added with purified water 1.3 times the weight of the spleen raw material and mixed evenly , to obta...

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Abstract

The invention provides a transfer factor and application thereof. The transfer factor is prepared by using a frozen-breaking process and a high-pressure breaking process in a combined manner, so that production temperature is lowered, and activity of the transfer factor can be maintained more efficiently; due to the fact that a freezing-thawing step is not needed, production period of semifinished products is shortened to be one day and shortened greatly when compared with that of conventional freezing-thawing methods and dialysis methods. In addition, transfer factor yield of the increased remarkably. Healthy pig spleen is taken as a raw material, a transfer factor solution is prepared through fat removing, cell breaking, microfiltration and ultrafiltration, the transfer factor does not contain protein, belongs to micromolecule polypeptide, is free of pyrogen and toxic reaction and is a widely-applied immunomodulator, and activity of the transfer factor cannot be damaged by pancreatin. The transfer factor can play a remarkable role in promoting immunity of livestock and poultry and is conducive to improving vaccine titer, prolonging antibody duration, enhancing an organism immune function and increasing treatment rate.

Description

technical field [0001] The invention relates to the technical field of immune promotion, in particular to a transfer factor and its application. Background technique [0002] Transfer factor (TF for short) is a substance released by lymphocytes that can transfer sensitization information. Animal TF generally has a molecular weight of 3,000 to 15,000 Da; The molecular weight, peptide molecular size and amino acid types of different antigen-specific TFs are slightly different; TF has no pyrogen, and its activity is not destroyed by trypsin, but it is unstable to heat and stable under freezing conditions. It can specifically transfer the donor's cellular immune information to the recipient, thereby enhancing the immune function of the recipient, and has become a widely used immune-enhancing agent abroad. [0003] In addition to being widely used in human medicine, transfer factor has also shown outstanding efficacy in veterinary medicine, especially in enhancing the immune eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/26A61P37/04
Inventor 王尚尚苏建东杨保收付旭彬梁武
Owner TIANJIN RINGPU BIO TECH
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