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Composition for preventing urinary stone

A composition and technology of urolithiasis, applied in the direction of drug combination, application, food science, etc., can solve the problems of high recurrence rate and no research

Inactive Publication Date: 2015-11-11
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has been no literature report on the intervention effect of prune juice on the generation of calcium oxalate kidney stones in rats, and there is no research on its further use in health care to prevent the occurrence of urinary stones
Urinary tract calculus is a frequently-occurring disease with a high recurrence rate. At present, there is no once-and-for-all preventive method

Method used

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  • Composition for preventing urinary stone
  • Composition for preventing urinary stone

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Experimental program
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Effect test

Embodiment

[0044] 1. Preparation

[0045] Shanghai Slack Laboratory Animal Co., Ltd. (SLAC) provided 40 healthy and clean adult male Wistar rats (body weight 180-220g); 1% ethylene glycol deionized water; Prune juice.

[0046] 2. Research methods

[0047] The prepared 40 rats were randomly divided into 5 groups, each with 8 rats, and they were adaptively fed in the same environment for 1 week, and then treated as follows for 4 weeks:

[0048] Group A (blank control group): drink deionized water;

[0049] Group B (simple inducement group): 1% ethylene glycol solution as the only source of drinking water;

[0050] Group C-Group E (Yu Shi + composition intervention group): 1% ethylene glycol solution as the only drinking water source, while giving 2ml / kg / d, 4ml / kg / d, 8ml / kg / d Plum juice.

[0051] 3. Testing indicators

[0052] The concentrations of urinary calcium, magnesium, oxalic acid and citrate in rats were detected; the concentrations of blood calcium, magnesium and creatinine; the content of mal...

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Abstract

The invention provides a composition for preventing urinary stone. The composition comprises 1wt% or more of a prune juice. The composition can be used as a health food or a health drug and can also comprise pharmaceutically or bromatologically acceptable carriers. The composition comprises prune juice ingredients as effective ingredients such as neochlorogenic acid, chlorogenic acid, caffeoylquinic acid, procyanidin oligomer, a flavonoid compound and rutin. An experiment proves that the prune juice has effects of preventing calcium oxalate calculus of kidney and provides a safe and effective prevention product with a simple source and a low price for kidney calcium oxalate calculus invalidous, subhealth people and health people.

Description

Technical field [0001] The invention relates to the field of preventive and health-care medicine and food, in particular to a composition for preventing urinary stones. Background technique [0002] Urinary calculi is a global disease and one of the most common urological diseases in my country. The incidence of calculi in different regions of the world is between 3% and 14%. Especially in southern my country, the incidence of urinary calculi is very high, and it is one of the three main endemic areas of urinary calculi in the world. At present, with the development of extracorporeal shock wave lithotripsy technology and intracavitary lithotripsy technology, great breakthroughs have been made in the diagnosis and treatment of urinary calculi. However, there is a problem of easy recurrence after treatment. Among them, the recurrence rate is as high as 50% in 10 years, especially the incidence of upper urinary tract stones is still on the rise, and the number of new patients every...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K36/815A61P13/04A23L1/29A61K31/352A23L33/00
Inventor 张士青
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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