A kind of GTR/GBR composite diaphragm loaded with doxycycline hydrochloride and preparation method thereof

A technology of doxycycline hydrochloride and composite membrane sheet, applied in the field of medicine, can solve problems such as unsolved problems and application limitations, and achieve the effects of avoiding drug contact, improving tissue affinity, and being beneficial to adhesion and growth.

Inactive Publication Date: 2017-12-26
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the initial burst release of 40%-50% of the drug inhibits the growth and proliferation of cells to a certain extent. The problem of the initial burst release of the drug has not been solved so far, which greatly limits the application of this technology.

Method used

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  • A kind of GTR/GBR composite diaphragm loaded with doxycycline hydrochloride and preparation method thereof
  • A kind of GTR/GBR composite diaphragm loaded with doxycycline hydrochloride and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] A preparation method of a GTR / GBR composite diaphragm loaded with doxycycline hydrochloride, comprising the following steps:

[0037] 1) Mix gelatin and polycaprolactone with an average molecular weight of 80,000 at a mass ratio of 1:1 and dissolve in hexafluoroisopropanol to prepare a surface electrospinning solution with a mass fraction of 8%, and degas it by ultrasonic 5min;

[0038] 2) Mix polycaprolactone and doxycycline hydrochloride at a mass ratio of 1:0.25 and dissolve in hexafluoroisopropanol to prepare a core layer electrospinning solution with a mass fraction of 10%, and degas it by ultrasonic for 5 ~8min;

[0039]3) The surface electrospinning solution and the core electrospinning solution prepared in step 1) and step 2) were respectively injected into two syringes of the electrospinning equipment, and electrospinning was carried out in a uniaxial sequence to obtain polyhydrochloride-containing hydrochloric acid. Cycycline's GTR / GBR three-layer composite ...

Embodiment 2

[0046] A preparation method of a GTR / GBR composite diaphragm loaded with doxycycline hydrochloride, comprising the following steps:

[0047] 1) Mix polycaprolactone and gelatin at a mass ratio of 1:0.5 and dissolve in hexafluoroisopropanol to prepare a surface electrospinning solution with a mass fraction of 10%, degassing by ultrasonication for 8 minutes; polycaprolactone The average molecular weight is 100,000;

[0048] 2) Mix polycaprolactone and doxycycline hydrochloride at a mass ratio of 1:0.2 and dissolve in hexafluoroisopropanol to prepare a core layer electrospinning solution with a mass fraction of 8%, and degas it by ultrasonication for 8 minutes ;

[0049] 3) The surface electrospinning solution and the core electrospinning solution prepared in step 1) and step 2) were respectively injected into two syringes of the electrospinning equipment, and electrospinning was carried out in a uniaxial sequence to obtain polyhydrochloride-containing hydrochloric acid. Cycycl...

Embodiment 3

[0054] A preparation method of a GTR / GBR composite diaphragm loaded with doxycycline hydrochloride, comprising the following steps:

[0055] 1) Mix polycaprolactone and gelatin at a mass ratio of 1:0.2 and dissolve in hexafluoroisopropanol to prepare a surface electrospinning solution with a mass fraction of 12%, degassing by ultrasonication for 8 minutes; polycaprolactone The average molecular weight is 80,000;

[0056] 2) Mix polycaprolactone and doxycycline hydrochloride at a mass ratio of 1:0.1 and dissolve in hexafluoroisopropanol to prepare a core layer electrospinning solution with a mass fraction of 12%, and degas it by ultrasonication for 6 minutes ;

[0057] 3) The surface electrospinning solution and the core electrospinning solution prepared in step 1) and step 2) were respectively injected into two syringes of the electrospinning equipment, and electrospinning was carried out in a uniaxial sequence to obtain polyhydrochloride-containing hydrochloric acid. Cycycl...

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Abstract

The invention discloses a GTR / GBR composite diaphragm loaded with doxycycline hydrochloride and a preparation method thereof, belonging to the technical field of medicine. The GTR / GBR composite diaphragm has a three-layer structure, and the upper and lower surface layers and the core layer are all passed through Made by sequential electrospinning, the upper surface layer and the lower surface layer are made of a mixture of natural polymer materials and synthetic polymer materials, and the core layer is a membrane layer made of a solution of synthetic polymer materials loaded with doxycycline hydrochloride . The invention adopts a uniaxial sequence electrospinning method to prepare a three-layer composite diaphragm, improves the encapsulation rate of the drug by the fiber, reduces / eliminates the initial burst release effect of the drug, and enables sustained and slow release of the drug. The double surface layer of the three-layer drug-loaded composite membrane of the present invention can not only be used as a pore barrier to control the release rate of the drug and realize sustained and stable release of the drug; The affinity is more conducive to tissue repair and regeneration.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a drug-loaded GTR / GBR composite membrane and a preparation method thereof, in particular to a multilayer GTR / GBR composite membrane loaded with doxycycline hydrochloride and a preparation method thereof. Background technique [0002] Peri-implantitis is inflammation of soft and hard tissues around implants, and the incidence rate is 28%-56%. Compared with traditional curettage and local medication, membrane-induced tissue regeneration and bone grafting can effectively fill bone defects, improve soft tissue morphology, increase new bone mass and re-osseointegration rate of bone tissue around the implant, and improve the stability of the implant. get improved. [0003] The oral cavity is a bacterial environment, and bacteria colonization on the surface of the implant affects the formation of osseointegration between the implant and the surrounding bone tissue, and at the same time h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/40A61F2/28
Inventor 贾骏贾列妮徐宏宇胡详刚谢乔王伟
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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