Composite molecularly imprinted solid-phase extraction column and its preparation method and application

Abstract

The invention discloses a preparation method of a composite molecularly imprinted solid-phase extraction column, which comprises the following steps: a. using triazine pesticides as template molecules to prepare molecularly imprinted polymer A; b. using sulfonylurea pesticides as template molecules to prepare molecules Imprinting polymer B; c, preparing a composite molecularly imprinted solid-phase extraction column. The composite molecularly imprinted solid-phase extraction column of the present invention can selectively enrich and extract triazine pesticides and sulfonylurea pesticides in samples at the same time, is easy to use, has good enrichment and extraction effects, and can be reused at least 20 times, with the advantages of economy, environmental protection and low cost, it is very suitable for the enrichment and extraction of triazine pesticides and sulfonylurea pesticides at the same time. The composite molecularly imprinted solid phase extraction column of the present invention is used for high performance liquid chromatography-tandem When mass spectrometry is used for detection, the detection results are accurate and reliable.

Description

technical field [0001] The invention relates to a composite molecular imprinted solid-phase extraction column and a preparation method and application thereof. Background technique [0002] Triazine and sulfonylurea herbicides are a class of herbicides with a six-membered heterocyclic structure. Since their introduction, they have been widely used worldwide as highly effective herbicides to prevent the growth of weeds in farmland, especially for cereal crops . Triazine herbicides are widely used all over the world, but the residues of these herbicides in crops will cause certain harm to the human body, and the safety of their residues in crops has attracted more and more attention. [0003] Molecularly imprinted polymers (MIPs) can selectively adsorb target compounds in complex matrices, and at the same time have certain mechanical strength and stability against acid, alkali and heat, and have long service life, high affinity and good selectivity. Excellent solid phase ext...

AI Technical Summary

Problems solved by technology

Triazine herbicides are widely used all over the world, but the residues of these herbicides in crops will cause certain harm to the human body, and the safety of their residues in crops has attracted more and more attention

[0004] At present, the disclosed molecularly imprinted solid phase extraction columns are mainly single molecule imprinted solid phase extraction columns, such as: the hydrophilic sulfonamide molecularly imprinted solid phase extraction column of Chinese CN104001486 A, the aminoglycoside drug molecule of Chinese patent CN102974327A Imprinted solid-phase extraction column, Chinese patent CN 102631902 A molecular imprinted solid-phase extraction column for coumarin rodenticides, this single-molecule imprinted solid-phase extraction column can only extract a certain type of drug, and then perform detection and analysis, while Simultaneous extraction and detection of two types of drugs cannot be realized; in the prior art, there is no report on the simultaneous extraction and detection of two or more types of drugs using a composite molecularly imprinted solid-phase extraction column

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