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Compound ivermectin vitamin B injection liquid and preparation method thereof

A technology of ivermectin and vitamins, which is applied in the field of compound ivermectin vitamin B injection and its preparation, can solve the problems of not being able to supplement the body's nutrients, not being able to enhance the body's resistance, and not being able to shorten the course of treatment, so as to enhance the body's Improve immunity, improve the body's insect resistance, and delay the effect of drug-resistant strains

Inactive Publication Date: 2015-11-18
CHONGQING BULL ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, single abamectin and ivermectin are mostly used to prevent and control parasitic infection, which can only drive away parasites, but cannot supplement the body's nutrients, cannot enhance the body's resistance, and cannot shorten the course of treatment. While using anti-parasitic drugs, drugs that enhance the body's own resistance are added to shorten the course of treatment, thereby reducing the chance of drug-resistant parasites

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The components and mass percentages of the compound ivermectin vitamin B injection of the present embodiment are:

[0022] Ivermectin 2%

[0023] Vitamin B 1 0.005%

[0024] Vitamin E Acetate 0.1%

[0025] Polyethylene Glycol - 400 50%

[0026] The balance is corn oil.

[0027] The preparation method of the compound ivermectin vitamin B injection of this embodiment is: first take the full amount of polyethylene glycol-400 and put it in the liquid mixing tank, then add the full amount of ivermectin therein, heat and stir until completely dissolved, Cool to room temperature, then add full dose of B vitamins 1 , stir until completely dissolved, then add the full amount of vitamin E acetate, and finally add corn oil to the full amount, filter to obtain the compound ivermectin vitamin B injection.

Embodiment 2

[0029] The components and mass percentages of the compound ivermectin vitamin B injection of the present embodiment are:

[0030] Ivermectin 1%

[0031] Vitamin B 12 0.01%

[0032] Vitamin E acetate 0.01%

[0033] Propylene Glycol 60%

[0034] The balance is peanut oil.

[0035] The preparation method of the compound ivermectin vitamin B injection of the present embodiment is as follows: first take the full amount of propylene glycol and place it in the liquid tank, then add the full amount of ivermectin therein, heat and stir until completely dissolved, cool to room temperature, and then Add a full dose of B vitamins 12 , stir until completely dissolved, then add the full amount of vitamin E acetate, and finally add peanut oil to the full amount, filter to obtain the compound ivermectin vitamin B injection.

Embodiment 3

[0037] The components and mass percentages of the compound ivermectin vitamin B injection of the present embodiment are:

[0038] Ivermectin 2%

[0039] Vitamin B 3 0.1%

[0040] Vitamin E Acetate 0.8%

[0041] Glycerin formal 55%

[0042] The balance is corn oil.

[0043] The preparation method of the compound ivermectin vitamin B injection of this embodiment is as follows: first take the full amount of glycerin formal in the liquid tank, then add the full amount of ivermectin therein, heat and stir until completely dissolved, and cool to room temperature, then add the full amount of vitamin B 3 , stir until completely dissolved, then add the full amount of vitamin E acetate, and finally add corn oil for injection to the full amount, and filter to obtain the compound ivermectin vitamin B injection.

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PUM

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Abstract

The invention discloses compound ivermectin vitamin B injection liquid. The injection liquid is mainly prepared from, by mass, 0.01-5% of ivermectin, 0.005-0.1% of vitamin B and the balance solvents for injection. The injection liquid is stable in quality, wide in insect-resistant spectrum and high in insect-resistant effect. Administration absorbing speed of subcutaneous or muscle injection is high and the bioavailability is high. The ivermectin and the vitamin B are combined for use, the parasite prevention effect is better, nutritional components required by a body can be supplemented, immunity of the body is enhanced, insect resistance of the body is improved, and the drug resistance probability of parasites is effectively reduced.

Description

technical field [0001] The invention relates to the technical field of veterinary drug injections, in particular to a compound ivermectin vitamin B injection and a preparation method thereof. Background technique [0002] Ivermectin has a broad antibacterial spectrum. It has the functions of killing insects, killing acarids and killing nematodes, and is often used in the prevention and control of livestock parasites. It has a good control effect on gastrointestinal nematodes, animal lung nematodes, psoriasis, lice, mites and ticks of various animals. Ivermectin is more easily absorbed by injection than oral administration, and the absorption rate is faster, the bioavailability is higher, and it has a better killing effect on certain parasites, especially arthropods. [0003] When the parasite parasitizes the host, it will continuously absorb its nutrients and release toxins, thereby reducing the body's immunity. When most worms parasitize and migrate in the host, they oft...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/714A61K9/08A61P37/04A61P3/02A61P33/10A61P33/14A61P33/00A61K31/51A61K31/355A61K31/455
Inventor 吴俊伟陈红伟曾杨梅姜波邓开锋王戬喻琴
Owner CHONGQING BULL ANIMAL PHARMA
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