The invention discloses selenium-rich and disease and pest resistant compound fertilizer. The selenium-rich and disease and pest resistant compound fertilizer is prepared from the following raw materials: monopotassium phosphate, controlled release nitrogen, grass carbon, soybean meal, sasanqua cake, rapeseed meal, amino acid, zinc sulphate, copper sulphate, ferrous sulphate, borax, 5- nitroguaiacol sodium salt, SiO2 soil improvement agent, selenium-rich yeast, alpha-pimacol, VB, VC and citric acid. The selenium-rich and disease and pest resistant compound fertilizer is scientific and rigorous in formula and is biofertilizer with selenium nutrition, resistance to disease and pest and pollution-free (low residue) effect, and a technology is scientific, organic, non-toxic, green and environmental-friendly. The selenium-rich and disease and pest resistant compound fertilizer can enhance a plant immunological function system, promote mobility of immune cells, regulate specific and non-specific immunological functions of a plant, effectively increase organic selenium content of the plant, realize a wound healing effect, rapidly promote new root development, cause the plant to be thick and strong, leaves to be thick, green, open and flat and root tubers and bulbs to be thickened and expanded, prevent premature senility and resist to cold, waterlogging, continuous cropping, salt and alkali.