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Medical anti-microbial dressing and preparation method thereof

A bacterial cellulose membrane and composite cross-linking agent technology, applied in the field of medical materials, can solve problems affecting large-scale production of products, long production cycle, unsatisfactory product stability, etc., to achieve improved stability, improved effect, cross-linking The effect of shortening the connection time

Inactive Publication Date: 2015-11-25
JIANGSU LANWAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the current conventional medical antibacterial dressings, there are not many dressings based on bacterial cellulose. At the same time, the dressing needs a long time of cross-linking and curing in the preparation process, and the production cycle is long, and the product after cross-linking with common cross-linking agents is stable. The performance is not ideal, which largely affects the mass production of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A medical antibacterial dressing, comprising bacterial cellulose membrane 300g, nano-silver 3g, water-soluble chitosan 30g, sodium alginate 9g, polyvinylpyrrolidone 6g and composite cross-linking agent 3g, wherein composite cross-linking agent is methacrylic acid -2-Hydroxyethyl ester and 2-ethyl-4-methylimidazole were heated to 50°C under the protection of ammonia gas, reacted for 40 minutes, cooled to room temperature, added lauroyl peroxide, and then heated at a pressure of 0.01MPa Heated to 60°C under negative pressure conditions, stirred and reacted for 20 minutes, wherein the mass ratio of lauroyl peroxide, 2-hydroxyethyl methacrylate and 2-ethyl-4-methylimidazole added above was 1 :3:2.

[0021] The preparation method of above-mentioned medical antibacterial dressing, comprises the following steps:

[0022] Step 1: Add sodium alginate into 540g of deionized water, heat to 50°C, stir and mix evenly to obtain mixed solution 1;

[0023] Step 2, dissolving polyviny...

Embodiment 2

[0027] A medical antibacterial dressing, comprising bacterial cellulose film 300g, nano silver 6g, water-soluble chitosan 60g, sodium alginate 15g, polyvinylpyrrolidone 9g and composite crosslinking agent 4g, wherein composite crosslinking agent is methacrylic acid -2-Hydroxyethyl ester and 2-ethyl-4-methylimidazole were heated to 53°C under the protection of ammonia gas, reacted for 45 minutes, cooled to room temperature, added lauroyl peroxide, and then heated at a pressure of 0.02MPa Heated to 63°C under negative pressure conditions, stirred and reacted for 24 minutes to obtain, wherein the mass ratio of lauroyl peroxide, 2-hydroxyethyl methacrylate and 2-ethyl-4-methylimidazole added above was 1 :3:2.

[0028] The preparation method of above-mentioned medical antibacterial dressing, comprises the following steps:

[0029] Step 1: Add sodium alginate into 900g of deionized water, heat to 55°C, stir and mix evenly to obtain mixed solution 1;

[0030] Step 2, dissolving pol...

Embodiment 3

[0034] A medical antibacterial dressing, comprising bacterial cellulose membrane 300g, nano-silver 6g, water-soluble chitosan 60g, sodium alginate 20g, polyvinylpyrrolidone 10g and composite cross-linking agent 3g, wherein composite cross-linking agent is methacrylic acid -2-Hydroxyethyl ester and 2-ethyl-4-methylimidazole were heated to 58°C under the protection of ammonia gas, reacted for 55 minutes, cooled to room temperature, added lauroyl peroxide, and then heated at a pressure of 0.03MPa Heated to 68°C under negative pressure conditions, stirred and reacted for 27 minutes, wherein the mass ratio of lauroyl peroxide, 2-hydroxyethyl methacrylate and 2-ethyl-4-methylimidazole added above was 1 :3:2.

[0035] The preparation method of above-mentioned medical antibacterial dressing, comprises the following steps:

[0036] Step 1: Add sodium alginate into 1400g of deionized water, heat to 58°C, stir and mix evenly to obtain mixed solution 1;

[0037] Step 2, dissolving polyv...

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Abstract

The invention discloses medical anti-microbial dressing and a preparation method thereof. The medical anti-microbial dressing comprises a bacterial cellulose membrane, nano-silver, water soluble chitosan, sodium alginate, polyvinylpyrrolidone and a composite cross-linking agent, wherein the composite cross-linking agent is prepared by compounding lauroyl peroxide, methacrylic acid-2-hydroxyethyl ester and 2-ethyl-4-methylimidazole. The preparation method comprises the steps that the sodium alginate is added into deionized water and is heated and mixed evenly to obtain a mixed liquid I; the polyvinylpyrrolidone is dissolved in ethylene glycol, the nano-silver is added, temperature rise is kept for a certain time, filtration is performed, solid matter is cleaned with deionized water and then is dried and smashed to obtain a material I; the water soluble chitosan and the material I are added into the mixed liquid I to be mixed evenly, the bacterial cellulose membrane is added, the composite cross-linking agent is added after the temperature rise is kept for a certain time, and temperature rise reaction is performed to obtain the anti-microbial dressing. The anti-microbial dressing has good anti-microbial dressing, bleeding-stop and wound surface healing effects and can be better applied to the medical field.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a medical antibacterial dressing and a preparation method thereof. Background technique [0002] Bacterial cellulose (BC), also known as microbial cellulose, is a polymer material with a unique nanostructure and excellent comprehensive properties. Due to its unique structure and better mechanical properties than plant cellulose, BC is expected to be used in many fields, such as tissue engineering and biomedical materials, optoelectronic materials, fuel cells, sewage treatment, food industry, paper industry and military industry, etc. Wait. BC fiber diameter is 20-100nm, and the single fiber length is very long. Therefore, BC has a high surface area per unit mass. This characteristic, together with its high hydrophilicity, is an important reason for BC's high water holding capacity. In addition, good biocompatibility makes it an attractive candidate material for a wide range o...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/20A61L15/18A61L15/42A61L15/44
Inventor 章祥庆唐海健
Owner JIANGSU LANWAN BIOTECH
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