Silica-coated ferroferric oxide nanocluster serving as magnetic labeling material and preparation method thereof

A technology of triiron tetroxide and silicon dioxide, which is used in the manufacture of inductors/transformers/magnets, inorganic material magnetism, electrical components, etc. Biocompatibility and safety, high efficiency, reproducible results

Active Publication Date: 2015-11-25
甘肃省科学院传感技术研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Another object of the present invention is to provide a method for preparing the silicon dioxide-coated ferric oxide nanoclusters, so as to solve the proble

Method used

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  • Silica-coated ferroferric oxide nanocluster serving as magnetic labeling material and preparation method thereof
  • Silica-coated ferroferric oxide nanocluster serving as magnetic labeling material and preparation method thereof
  • Silica-coated ferroferric oxide nanocluster serving as magnetic labeling material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1, Fe 3 o 4 The preparation steps of NCs are as follows:

[0029] 0.225gFeCl 3 ·6H 2 O and 0.6g NaAc 3H 2 O was dissolved in 40ml of ethylene glycol, transferred to a polytetrafluoroethylene reaction kettle, and reacted at 180°C for 8 hours. After the reaction was completed, it was magnetically separated, washed with absolute ethanol and deionized water, and placed in a drying oven. , dried at 60°C for 8 h to obtain Fe 3 o 4 NCs; this embodiment has the best effect.

Embodiment 2

[0030] Example 2, Fe 3 o 4 The preparation steps of NCs are as follows:

[0031] 0.338gFeCl 3 ·6H 2 O and 0.9g NaAc 3H 2 O was dissolved in 40ml of ethylene glycol, transferred to a polytetrafluoroethylene reaction kettle, and reacted at 180°C for 8 hours. After the reaction was completed, it was magnetically separated, washed with absolute ethanol and deionized water, and placed in a drying oven. , dried at 60°C for 8 h to obtain Fe 3 o 4 NCs.

Embodiment 3

[0032] Example 3, Fe 3 o 4 The preparation steps of NCs are as follows:

[0033] 0.225gFeCl 3 ·6H 2 O and 0.563g NaAc 3H 2 O was dissolved in 40ml of ethylene glycol, transferred to a polytetrafluoroethylene reaction kettle, and reacted at 180°C for 8 hours. After the reaction was completed, it was magnetically separated, washed with absolute ethanol and deionized water, and placed in a drying oven. , dried at 60°C for 8 h to obtain Fe 3 o 4 NCs.

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Abstract

The invention discloses a silica-coated ferroferric oxide nanocluster serving as a magnetic labeling material and a preparation method thereof. The method includes the steps that first, with iron chloride hexahydrate and sodium acetate trihydrate as raw materials and ethanediol as solvent, Fe3O4NCs with good dispersity, high magnetic response and superparamagnetism is prepared by improving a solvothermal method; then, with the cluster as a precursor, absolute ethyl alcohol and deionized water as a dispersant and ethyl orthosilicate and strong ammonia water as raw materials, the silica-coated ferroferric oxide nanocluster is synthesized with assistance of ultrasonic waves under the condition of a normal-temperature water bath. The silica-coated ferroferric oxide nanocluster composite obtained through the method has excellent magnetic performance, the thickness of a silica shell is uniform and is kept within 10-20 nm, the surface carries a large number of silicon hydroxyls, excellent biological safety and compatibility are achieved, and the requirement of a magnetic micro-nano sensor for the magnetic labeling material is met.

Description

technical field [0001] The invention belongs to the field of composite materials, and in particular relates to a magnetic nano composite material and a preparation method thereof. Background technique [0002] With the emergence of biomolecular magnetic labeling technology, magnetic micro-nano biosensors developed by combining magnetic micro-nano sensors and biomolecular magnetic labeling technology have been widely used in the detection of biomolecules. Because magnetic labels are very stable, they are not affected by chemical reactions or light. The effect of bleaching, by applying a magnetic field, magnetic labels can be manipulated on the chip and can be used for molecular positioning or identification. [0003] Magnetic particles applied to magnetic micro-nano biosensors for magnetic labeling must have the following properties: 1) Superparamagnetic, because if the magnetic particles have remanence, they will lose the ability to resuspend and disperse, so they no longer ...

Claims

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Application Information

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IPC IPC(8): H01F1/11H01F41/02
Inventor 韩根亮冯治棋左显维张彪李工农刘斌
Owner 甘肃省科学院传感技术研究所
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