Preparation method and application of rhizome traditional Chinese medicinal material decocting-free preparation

A technology of traditional Chinese medicinal materials and rhizomes, which is applied in the field of traditional Chinese medicine preparation, can solve the problems of difficult dissolution and release of active ingredients, incomplete extraction of active ingredients, and destruction of active ingredients of medicinal materials, etc., to increase solvent penetration, increase dissolution rate and dissolution rate. The number of times, the effect of improving the concentration and drying efficiency

Inactive Publication Date: 2015-12-09
HENAN XINGZHI PATENT SERVICE CO LTD
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Problems solved by technology

Due to the complex chemical composition of rhizome Chinese medicinal materials, most of which contain active ingredients of saponins and alkaloids, traditional extraction methods will destroy the active ingredients in medicinal materials
The specific surface area of ​​traditional rhizome Chinese medicine pieces is small, and the active ingredients are not easy to dissolve and release. Using traditional extraction methods will lead to incomplete extraction of active ingredients, low extraction yield, and long extraction time

Method used

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  • Preparation method and application of rhizome traditional Chinese medicinal material decocting-free preparation

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preparation example Construction

[0027] A method for preparing rhizome-like Chinese medicinal material decoction-free preparation, comprising the following steps:

[0028] 1) Pick up the rhizome Chinese medicinal materials to remove impurities, dry, pulverize, and pass through a 10-15 mesh sieve to obtain the rhizome Chinese medicinal materials coarse powder;

[0029] 2) Put the rhizome-like Chinese medicinal material coarse powder obtained in step 1) into a steam explosion machine, inject high-pressure steam for steam explosion, and obtain the Chinese medicinal material steam-exploded wall breaking powder;

[0030] 3) Add an ethanol solution with a volume ratio of 65%~75% to the Chinese medicinal material steam explosion wall breaking powder obtained in step 2), control the material-liquid ratio to 1:5~1:8, and soak at 50~60°C for 3 ~6h, then ultrasonic treatment, filtration, to obtain filtrate and filter residue;

[0031] 4) Add 12-15 times the volume of water to the filter residue obtained in step 3), soa...

Embodiment 1

[0043] Taking Pulsatilla pulsatillae as an example, its decoction-free preparation method comprises the following steps:

[0044] 1) Pick up the pulsatilla, remove impurities, dry, pulverize, and pass through a 10-15 mesh sieve to get the pulsatilla coarse powder;

[0045] 2) Put the Pulsatillae coarse powder obtained in step 1) into the steam explosion machine, feed high-pressure steam to make the internal pressure of the steam explosion machine 0.6 MPa, maintain the time for 3 minutes, release the pressure and steam explosion, and obtain Psyllium pulsatillae steam explosion wall-breaking powder;

[0046] 3) Add an ethanol solution with a volume ratio of 65% to the Pulsatilla vulgaris steam-exploded wall-breaking powder obtained in step 2), control the material-to-liquid ratio to 1:5, soak at 50°C for 3 hours, and then ultrasonically treat it with an ultrasonic frequency of 15kHz and power 300W, time 25min, repeat twice, filter to obtain filtrate and filter residue;

[0047]...

Embodiment 2

[0051] Taking Coptidis Rhizome as an example, its decoction-free preparation method comprises the following steps:

[0052] 1) Pick up Coptis chinensis, remove impurities, dry, crush, and pass through a 10-15 mesh sieve to obtain Coptis chinensis coarse powder;

[0053] 2) Put the coarse powder of Coptidis Rhizoma obtained in step 1) into the steam explosion machine, feed high-pressure steam to make the internal pressure of the steam explosion machine 0.7MPa, maintain the time for 4min, release the pressure and steam explosion, and obtain Coptis chinensis steam explosion wall-breaking powder;

[0054] 3) Add ethanol solution with a volume ratio of 70% to the Coptidis steam-exploded wall powder obtained in step 2), control the ratio of solid to liquid to 1:6, soak at 55°C for 4 hours, and then ultrasonically treat it, ultrasonic frequency 18kHz, power 350W, time 26min, repeat 3 times, filter to obtain filtrate and filter residue;

[0055] 4) Add 13 times the volume of water to...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a preparation method and application of a rhizome traditional Chinese medicinal material decocting-free preparation. The preparation method comprises the following steps: performing steam explosion wall-breaking treatment on a rhizome traditional Chinese medicinal material; then extracting active ingredients by adopting a manner of combination of ultrasonic assisted alcohol extraction and ultrahigh pressure extraction; then performing microfiltration treatment by adopting a ceramic membrane; and finally, performing concentration, drying and nano pulverization to obtain the rhizome traditional Chinese medicinal material decocting-free preparation. The preparation can be used for preparing a traditional Chinese medicine compound preparation containing the rhizome traditional Chinese medicinal material or a rhizome traditional Chinese medicinal material extract. By adopting the preparation method, the problems of low raw material utilization ratio, incomplete extraction of active ingredients and low extraction efficiency of a conventional method for extracting traditional Chinese medicinal materials are solved, the whole process flow is simple to control and is green and environment-friendly, and all process steps achieve a synergistic effect, so that the preparation method provided by the invention is higher in extraction efficiency, the active ingredients are effectively protected, and the utilization degree of the rhizome traditional Chinese medicinal material is improved.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and in particular relates to a preparation method and application of rhizome-like traditional Chinese medicinal materials decoction-free. Background technique [0002] Traditional Chinese medicine is a unique medicine of traditional Chinese medicine, with a long history and rich resources. The ingredients of traditional Chinese medicine are complex and diverse. If the appropriate extraction, concentration, preparation process and scientific and strict process operation parameters are not selected during the preparation of traditional Chinese medicine preparations, the active ingredients will be incompletely extracted or even destroyed, thereby affecting the efficacy of the medicine. The traditional dosage forms of traditional Chinese medicine include pills, powders, ointments, liquors, etc., but most of the traditional dosage forms have shortcomings such as la...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00
CPCA61J3/00
Inventor 马新攀
Owner HENAN XINGZHI PATENT SERVICE CO LTD
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