Antibody coupled mesoporous silica/mifepristone nanometer preparation

A technology of mesoporous silica and mifepristone, which is applied in the direction of antibodies, medical preparations with inactive ingredients, inactive ingredients of polymer compounds, etc., to achieve inhibitory activity, prevent tumor metastasis, and prevent CTCs from adhering to blood vessels Endometrial effect

Active Publication Date: 2015-12-09
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Retrieval of relevant literature and patents at home and abroad shows that so far, there is no drug that can specifically target CTCs and regulate the activity of CTCs to prevent and inhibit micrometastasis

Method used

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  • Antibody coupled mesoporous silica/mifepristone nanometer preparation
  • Antibody coupled mesoporous silica/mifepristone nanometer preparation
  • Antibody coupled mesoporous silica/mifepristone nanometer preparation

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Embodiment 1

[0030] (1) Measure 20mL of ultrapure water into a 50mL round bottom flask, add 2.0g of cetyltrimethylammonium chloride (CTAC), stir at room temperature until completely dissolved, add 0.02mg of triethanolamine (TEA), in 95 ℃ oil bath constant temperature heating and condensation stirring for 1h. Then 1.5 mL of tetraethylsilane (TEOS) was added dropwise, and continued to heat, condense and stir in an oil bath at 95°C for 1 h. The sample was cooled to room temperature, and washed 3-4 times by high-speed centrifugation with absolute ethanol to remove residual reaction reagents. Then collect the samples in 20mL of washing solvent (0.2g sodium chloride dissolved in 20mL methanol), stir at room temperature for 3h, and wash with high-speed methanol centrifugation. Repeat the above washing step 3-4 times to remove the templating agent CTAC. Freeze-dry to obtain white MSN solid powder.

[0031](2) Measure 2.5mL of 3-aminopropyltriethoxysilane (APTES) and 75mg of succinic anhydride i...

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Abstract

The invention discloses an antibody coupled mesoporous silica/mifepristone nanometer preparation and a preparing method and application thereof. The preparation is prepared from mesoporous silica nanoparticles (MSN), mifepristone (MIF) and epithelial cell adhesion molecule antibodies (anti-EpCAM, aE), MIF is carried by MSN, and the surface of the MSN is covalently modified by aE. The ntibody coupled mesoporous silica/mifepristone nanometer preparation can recognize in a targeting mode, restrain activity of circular tumor cells (CTCs), restrain adhesion between the CTCs and endangium, disturb a tumor metastasis process and remarkably restrain tumor metastasis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an antibody-coupled mesoporous silicon dioxide / mifepristone nano-preparation and a preparation method and application thereof. Background technique [0002] Tumor metastasis is one of the main reasons for tumor refractory and recurrence. The primary tumor can be effectively controlled or even cured by surgical resection, radiotherapy or other local treatments, but it is often difficult to control the further development of the disease with the above-mentioned methods for the spread of the tumor. Tumor metastasis is composed of a series of cascading steps: (1) primary tumor cells invade the adjacent extracellular matrix and interstitial cell layer; (2) invade the vessel wall; (3) penetrate the vasculature; (4) ) Adhesion and implantation in distal tissues; (5) Leaving the circulation to the surrounding interstitium; (6) Adapting to the new environment to form micr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/567A61K39/395A61K47/48A61K47/42A61P35/04
Inventor 高瑜贾力顾颂恩
Owner FUZHOU UNIV
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