A kind of Scutellaria baicalensis total flavonoids dispersible tablet and preparation method thereof

Abstract

The present invention provides a manufacturing method of Scutellaria baicalensis general flavone dispersible tablets. The method comprises the steps of: A) stirring, mixing and granulating a Scutellaria baicalensis extract and accessory materials by a high-speed stirring molding machine, wherein the Scutellaria baicalensis general flavones in the Scutellaria baicalensis extract is no less than 45%, and the accessory material include a disintegrants containing CMS-Na and PVPP, a filler containing microcrystalline cellulose and TY, and lauryl sodium sulfate and NP; and B) drying the prepared granules, sieving through a screen of 30 mesh and finishing to obtain particles no more than 30 mesh, adding PVPP, silica powder and disintegrant, pressing to obtain Scutellaria baicalensis general flavone dispersible tablets, wherein the disintegrant comprises CMS-Na and PVPP.

Description

technical field [0001] The invention relates to a tablet of total flavonoids of Scutellaria baicalensis and a manufacturing method thereof, in particular to a dispersible tablet of total flavonoids of Scutellaria baicalensis and a manufacturing method thereof. Background technique [0002] Scutellaria baicalensis is a famous traditional Chinese medicine in my country. It was first recorded in "Shen Nong's Materia Medica" and listed as a top-grade herbal root medicine. Traditional Chinese medicine believes that Scutellaria baicalensis has the functions of clearing away heat and dampness, purging fire and detoxification, hemostasis, and anti-abortion. Sore boils and other diseases. The effective components of Scutellaria baicalensis are flavonoids, and there are more than a dozen flavonoids extracted from Scutellaria baicalensis and their structures identified. Modern pharmacological studies have shown that Scutellaria baicalensis has antibacterial, antihypertensive, sedativ...

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Problems solved by technology

[0010] Dispersible tablets are mainly suitable for: ① Carbamazepine is insoluble in water and the drug with bioavailability problems. The commonly used dosage form is tablet. The oral absorption is slow and incomplete, and the dissolution rate is difficult to meet the requirements of the Pharmacopoeia.

[0011] ② Drugs with large doses: such as acetaminophen and oxapromazine, due to the large doses of drugs, it is often necessary to take multiple tablets at a time, which especially brings inconvenience to the elderly, young and patients with dysphagia

[0017] (2) Ordinary tablets and capsules are large in size, or often need to use multiple tablets (granules) at a time, especially for the treatment of the elderly, young and patients who have difficulty swallowing solids.

Although extrusion granulation can also prepare dispersible tablets, the quality of the granules is generally poor, which affects the disintegration and dissolution of the tablet

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