Polyglycosidated pentacyclic triterpene-28-acid, and preparation method and application thereof

A pentacyclic triterpene and polysaccharide technology, which is applied in the field of medicine and its preparation and application, can solve the problems of restricted application, poor water solubility, and low bioavailability, and achieve the effects of small toxic and side effects, enhanced water solubility, and good water solubility
CN105175477AInactive Publication Date: 2015-12-23JIANGXI AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGXI AGRICULTURAL UNIVERSITY
Publication Date
2015-12-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a polyglycosidated pentacyclic triterpene-28-acid, and a preparation method and an application thereof. The water solubility of polyhydroxypentacyclic triterpene-28-acid is further enhanced on the basis of maintaining or improving the activity of the polyhydroxypentacyclic triterpene-28-acid, and a plurality of glycosyl groups are introduced to the hydroxyl position of polyhydroxypentacyclic triterpene-28-acid and are glycosidated to synthesize a series of the polyglycosidated pentacyclic triterpene-28-acid with good water solubility. Researches show that like compounds have good in vitro alpha-glucosidase inhibition activity. The invention provides a method for screening an alpha-glucosidase inhibitor with the advantages of good water solubility, high inhibition activity, mild effects and small toxic and side effects. The screening method can be widely used in subsequent anti-diabetic clinic fields.
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Description

technical field

[0001] The invention relates to the technical field of medicine and its preparation and application, in particular to a polyglycosidated pentacyclic triterpene-28-acid, its preparation method and its application in the preparation of antidiabetic drugs. Background technique

[0002] Diabetes is a metabolic disease characterized by chronically elevated blood sugar levels. In recent years, the morbidity and mortality have shown a rapid upward trend, becoming the third major disease that threatens human health after tumors and cardiovascular diseases. At present, the main methods of diagnosis and treatment are to control blood sugar concentration by injecting insulin and oral hypoglycemic drugs. At present, the more common chemical drugs mainly include biguanide compounds, thiazolidinediones (TZDs) and sulfonylurea compounds. Although these synthetic drugs have quick effects and obvious curative effects, they also have relatively large side effects. Therefore, ...

Claims

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