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Polylactic acid stereo complex magnetic nanometer vesicle preparation method

A technology of stereocomplex and magnetic nanotechnology, which is applied in the fields of polymer materials and biomedical engineering, can solve the problems of poor stability of nanovesicles and easy leakage of loaded nanoparticles, and achieve the best stability effect

Inactive Publication Date: 2015-12-23
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to prepare polylactic acid stereocomplexes into nanovesicles capable of encapsulating magnetic nanoparticles, so as to solve the defects of poor stability of conventional polymer nanovesicles and easy leakage of loaded nanoparticles

Method used

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  • Polylactic acid stereo complex magnetic nanometer vesicle preparation method
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Examples

Experimental program
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Effect test

Embodiment 1

[0022] Take 0.2g of polyethylene glycol monomethyl ether with a molecular weight of 2000, 0.1g of L-lactide and 0.1mg of stannous octoate into a reaction bottle, protect with argon, react at 110°C for 12 hours, dissolve dichloromethane, and precipitate with ether 2 to 3 times, filter, and vacuum dry the filter cake to obtain L-polylactic acid-polyethylene glycol block copolymer; take 0.2g of polyethylene glycol monomethyl ether with a molecular weight of 2000, 0.1g of D-lactide and octanoic acid Put 0.2 mg of stannous into the reaction bottle, under argon protection, react at 105°C for 12 hours, dissolve in dichloromethane, precipitate with ether for 2 to 3 times, filter, and dry the filter cake in vacuum to obtain the D-polylactic acid-polyethylene glycol block Copolymer; Dissolve the product in dichloromethane respectively, and prepare 10mg / mL L-polylactic acid-polyethylene glycol block copolymer solution and D-polylactic acid-polyethylene glycol block copolymer solution. Th...

Embodiment 2

[0025] Take 0.2g of polyethylene glycol monomethyl ether with a molecular weight of 2000, 0.1g of L-lactide and 0.1mg of stannous octoate into a reaction bottle, protect with argon, react at 110°C for 12 hours, dissolve dichloromethane, and precipitate with ether 2 to 3 times, filter, and vacuum dry the filter cake to obtain L-polylactic acid-polyethylene glycol block copolymer; take 0.2g of polyethylene glycol monomethyl ether with a molecular weight of 2000, 0.1g of D-lactide and octanoic acid Put 0.2 mg of stannous into the reaction bottle, under argon protection, react at 105°C for 12 hours, dissolve in dichloromethane, precipitate with ether for 2 to 3 times, filter, and dry the filter cake in vacuum to obtain the D-polylactic acid-polyethylene glycol block Copolymer; Dissolve the product in dichloromethane respectively, and prepare 10mg / mL L-polylactic acid-polyethylene glycol block copolymer solution and D-polylactic acid-polyethylene glycol block copolymer solution. Th...

Embodiment 3

[0028]Take 0.25g of polyethylene glycol monomethyl ether with a molecular weight of 5000, 0.12g of L-lactide and 0.13mg of stannous octoate into a round bottom flask, protect it with argon, and react at 130°C for 24 hours, dissolve dichloromethane, diethyl ether Precipitate 2 to 3 times, filter, and vacuum-dry the filter cake to obtain L-polylactic acid-polyethylene glycol block copolymer; take 0.25g of polyethylene glycol monomethyl ether with a molecular weight of 5000, 0.12g of D-lactide and Put 0.13 mg of stannous octoate into a round-bottomed flask, protect it with argon, react at 130°C for 24 hours, dissolve in dichloromethane, precipitate with ether for 2 to 3 times, filter, and dry the filter cake in vacuum to obtain D-polylactic acid-polyethylene glycol Block copolymer; dissolve the product in dichloromethane respectively, and make 15mg / mL L-polylactic acid-polyethylene glycol block copolymer solution and D-polylactic acid-polyethylene glycol block copolymer solution ...

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Abstract

The present invention belongs to the field of polymer materials and biomedical engineering, and particularly relates to a polylactic acid stereo complex magnetic nanometer vesicle preparation method, which specifically comprises that: L-polylactic acid and D-polylactic acid respectively react with polyethylene glycol to synthesize two different block copolymers, then stereo compounding is performed, and nanometer magnetic particles are entrapped so as to form the polylactic acid stereo complex magnetic nanometer vesicle adopting the hydrophobic stereo composite polylactic acid as the film and having the inner layer and the outer layer being the hydrophilic polyethylene glycol chains, wherein the obtained nanometer vesicle has excellent stability due to the strong intermolecular interaction of the stereo complex, and the magnetic particles are wrapped in the compact polylactic acid film structure so as not to be easily leaked. According to the present invention, the magnetic nanometer vesicles can be used as the enhancement contrast agent in the clinical magnetic resonance imaging, and can further load drugs or biological macromolecules so as to be used as the release controlling nanometer carrier of drug or gene therapy.

Description

technical field [0001] The invention belongs to the fields of polymer materials and biomedical engineering, and in particular relates to a preparation method of polylactic acid stereocomplex magnetic nanovesicles. Background technique [0002] Polylactic acid (PLA) is a biocompatible and biodegradable polymer that has been approved for human use by regulatory agencies in many countries, including the U.S. FDA. It has the advantages of being non-toxic to the human body, non-irritating, controllable biodegradation, good biocompatibility, and easy to obtain raw materials. Therefore, polylactic acid and its copolymers have become a kind of biodegradable biomedical materials that have attracted much attention. Polymer Materials. In biomedicine, polylactic acid was mainly used in surgical sutures, orthopedic internal fixation materials and in vivo filling materials in the early days. In recent years, it has gradually attracted people's attention in tissue engineering scaffolds, d...

Claims

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Application Information

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IPC IPC(8): C08J5/00C08L67/04C08K3/22C08G63/664C08G63/78
Inventor 李建波蔡泉任杰
Owner TONGJI UNIV
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