Sennoside A.B salt compound as well as preparation method and application thereof

A technology of sennosides and compounds, which is applied in the field of medicine, can solve problems such as unfavorable popularization and clinical application of patent medicines for treating constipation, poor stability of sennoside A·B, etc., to achieve favorable promotion and clinical application, stable active ingredients, The effect of high purity

Active Publication Date: 2016-01-20
ANHUI JIUFANG DRUG RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The object of the present invention is to provide a kind of sennoside A·B salt compound and preparation method thereof, the application of described sennoside A·B salt co

Method used

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  • Sennoside A.B salt compound as well as preparation method and application thereof
  • Sennoside A.B salt compound as well as preparation method and application thereof
  • Sennoside A.B salt compound as well as preparation method and application thereof

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preparation example Construction

[0034] Specifically, the preparation method of the sennoside A·B salt compound comprises the following steps:

[0035] (a) extracting senna leaves with an aqueous solution of sodium bicarbonate to obtain an extract, and filtering the extract through a 100-mesh to 200-mesh sieve to obtain a filtered extract;

[0036] (b) After the filtered extract obtained in step (a) is acidified, the acidified product obtained is subjected to solid-liquid separation to obtain liquid phase component A, and the liquid phase component A is filtered through molecular interception Obtain fine filtrate;

[0037] (c) mixing activated clay with the fine filtrate obtained in step (b), stirring and adsorbing, separating the adsorbed mixture from solid to liquid, and eluting the obtained solids successively with water and water-containing alcohol, and the eluted The solid is subjected to solid-liquid separation to obtain the liquid phase component B;

[0038] (d) concentrating the liquid phase compone...

Embodiment 1

[0064] Crush the senna leaves of the prescribed amount, add 10 times the mass of 0.5wt% sodium bicarbonate aqueous solution to carry out stirring and extraction at room temperature for 3 hours, collect the extract, filter, add 0.5mol / L hydrochloric acid to the filtrate to adjust the pH value to 4, and stir , stand still, filter to obtain the medicinal solution, carry out the molecular interception filtration of the obtained medicinal solution through a ceramic membrane filter, the ceramic membrane filter aperture is 0.2 μm, and obtain the fine filtrate; add 5% activated clay to the fine filtrate, stir for 3 hours, Filter, add 5 times the volume of activated clay to wash with water to remove impurities, then elute with 90wt% ethanol solution, collect the eluate, add anhydrous calcium sulfate to remove water, and then remove the impurities at a temperature of 60°C and a vacuum of -0.08MPa Concentrate under reduced pressure for 2 hours;

[0065] Mix the obtained concentrate with ...

Embodiment 2

[0069] Get the senna leaf of recipe quantity, pulverize, add 0.2wt% sodium bicarbonate aqueous liquid of 8 times amount and carry out room temperature stirring extraction for 2 hours, collect extract, filter, add the hydrochloric acid of 0.5mol / L to filtrate, adjust the pH value to 3. Stir, stand still, and filter to obtain the filtrate, carry out molecular interception filtration through the obtained medicinal liquid through a ceramic membrane filter, the aperture of the ceramic membrane filter is 0.1 μm, and obtain the fine filtrate; 5% activated clay of the fine filtrate is stirred for 2 hour, filter, and the gained activated clay is washed with water of 3 times the volume to remove impurities, then eluted with 90wt% ethanol solution, collects the eluent, adds anhydrous calcium sulfate to remove moisture, and at a temperature of 80°C and a vacuum of - Concentrate under reduced pressure for 1 hour under the condition of 0.1MPa;

[0070] Mix the obtained concentrate with 0.5m...

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Abstract

The invention relates to a sennoside A.B salt compound as well as a preparation method and an application thereof. The sennoside A.B salt compound with high-purity active ingredients sennoside A and sennoside B is obtained by using senna leaves as raw materials and carrying out extraction, filtration, acidification, refined filtration, extraction, refinement, compound salifying and precipitation and purification and has purity between 80% and 90%. Clinically required dosage forms are prepared from the sennoside A.B salt compound and proper auxiliary materials and have obvious effects and good stability when being clinically used for preventing or treating constipation. The sennoside A.B salt compound has a good function of relaxing the bowels and has the advantages of good safety, quickness in effect taking, strong functions, high bioavailability, stable curative effects, convenience in use, and the like when being used for treating constipation. Industrial production equipment is concise, is convenient to operate, is low in cost, has high degree of automation and is easy in control of product quality.

Description

technical field [0001] The invention mainly relates to the technical field of medicine, in particular to a sennoside A·B salt compound, a preparation method thereof, and an application thereof in preparation of a medicine for treating constipation. Background technique [0002] Senna leaves are the dry leaflets of the leguminous plant Cassia angustifolia or Cassia acutifoliadelile. They are usually harvested in summer when they are in full bloom, sliced ​​and dried in the sun. It is used for thermal solution stagnation, constipation and abdominal pain, edema and fullness. [0003] Senna leaves are commonly used in modern Chinese medicine to treat various types of constipation, and clinically significant results have been achieved. Studies have shown that sennosides (Sennosides) are dianthrone derivatives, which are a component with a relatively high content in senna leaves, and are also the main active ingredients of senna leaves for diarrhea and hemostasis. Sennosides have...

Claims

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Application Information

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IPC IPC(8): C07H15/244C07H1/08A61P1/10
Inventor 李晓亮邵旭牛海军
Owner ANHUI JIUFANG DRUG RES INST CO LTD
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