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Zinc-doped prussian blue nanoparticle, preparation method and applications thereof

A Prussian blue and nanoparticle technology, which is used in preparations, pharmaceutical formulations, and emulsion delivery for in vivo experiments to achieve the effects of improving biocompatibility, easy control of the control process, and high light absorption efficiency.

Active Publication Date: 2016-02-03
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the water-soluble Prussian blue KFe[Fe(CN) 6 ] Due to the presence of potassium ions, intravenous application is limited, while Fe 4 [Fe(CN) 6 ] 3 insoluble in water

Method used

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  • Zinc-doped prussian blue nanoparticle, preparation method and applications thereof
  • Zinc-doped prussian blue nanoparticle, preparation method and applications thereof
  • Zinc-doped prussian blue nanoparticle, preparation method and applications thereof

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Embodiment 1

[0037] This embodiment provides a method for preparing zinc-doped Prussian blue nanoparticles, comprising the following steps:

[0038] Step 1: Dissolve 329mg potassium ferricyanide and 400mg citric acid in 50mL ethanol, mix and stir evenly, and prepare A solution;

[0039] Step 2: Dissolve 127mg of ferrous chloride and 400mg of citric acid in 25mL of ethanol, mix and stir evenly, and prepare B solution;

[0040] Step 3: Dissolve 236mg of zinc methacrylate in 25mL of ethanol, mix and stir evenly, and prepare C solution;

[0041] Step 4: Magnetically stir solution C evenly, heat to 80°C and reflux for 1 hour, then add solution B, mix and stir evenly, then add solution A drop by drop, react with magnetic force for 3 hours, and centrifuge to obtain intermediate product D;

[0042] Step 5: Dissolve the intermediate product D in 100 mL of ethanol, heat to 70°C, then add 50 mg of azobisisobutyronitrile, stir for 5 minutes with magnetic force, and then add 7.5 mL of poly(ethylene gl...

Embodiment 2

[0044] This embodiment provides a method for preparing zinc-doped Prussian blue nanoparticles, comprising the following steps:

[0045] Step 1: Dissolve 422mg of potassium ferrocyanide and 800mg of diethyltriaminepentaacetic acid in 50mL of ethanol, mix and stir evenly, and prepare A solution;

[0046] Step 2: Dissolve 162mg of ferric chloride and 400mg of diethyltriaminepentaacetic acid in 25mL of ethanol, mix and stir evenly, and prepare B solution;

[0047] Step 3: Dissolve 236mg of zinc methacrylate in 25mL of ethanol, mix and stir evenly, and prepare C solution;

[0048] Step 4: Magnetically stir solution C evenly, heat to 60°C and reflux for 1 hour, then add solution B, mix and stir evenly, then add solution A drop by drop, react with magnetic force for 3 hours, and centrifuge to obtain intermediate product D;

[0049] Step 5: Dissolve the intermediate product D in 100 mL of ethanol, heat to 60°C, then add 50 mg of dimethyl azobisisobutyrate, stir for 5 minutes with mag...

Embodiment 3

[0051] This embodiment provides a method for preparing zinc-doped Prussian blue nanoparticles, comprising the following steps:

[0052] Step 1: Dissolve 484mg of sodium ferrocyanide and 500mg of malic acid in 50mL of ethanol, mix and stir evenly, and prepare A solution;

[0053] Step 2: Dissolve 127mg of ferrous chloride and 500mg of malic acid in 25mL of ethanol, mix and stir evenly, and prepare B solution;

[0054] Step 3: Dissolve 236mg of zinc methacrylate in 25mL of ethanol, mix and stir evenly, and prepare C solution;

[0055] Step 4: Stir the solution C evenly with magnetic force, heat to 100°C and reflux for 1 hour, then add the solution B, mix and stir evenly, then add the solution A drop by drop, react with magnetic force for 2 hours, and centrifuge to obtain the intermediate product D;

[0056] Step 5: Dissolve the intermediate product D in 100mL of ethanol, heat to 100°C, then add 20mg of azobisisoheptanonitrile, stir for 10min with magnetic force, then add 4ml of...

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Abstract

The present invention provides a zinc-doped prussian blue nanoparticle preparation method, wherein a hexaoyanoferrous acid substance and zinc methacrylate are adopted as raw materials, an organic acid with a specific concentration is matched to prepare the zinc-doped prussian blue nanoparticles having double bond on the surface, and an organic layer having carboxyl, amino, hydroxyl and other functional groups is modified on the nanoparticle surface through a polymerization reaction. Another purpose of the present invention is to provide the zinc-doped prussian blue nanoparticles prepared through the preparation method, and clinical applications of the zinc-doped prussian blue nanoparticles as the contrast agent in magnetic resonance imaging and photoacoustic bifunctional imaging. According to the present invention, the prepared zinc-doped prussian blue nanoparticles have characteristics of good water solubility, good biocompatibility and good light-heat stability, and amino, carboxyl or hydroxyl and the like are modified on the nanoparticle surface so as to provide favorable conditions for the further surface modification and antibody grafting.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a zinc-doped Prussian blue nanoparticle and a preparation method thereof, as well as its clinical application as a magnetic resonance and photoacoustic dual-function imaging contrast agent. Background technique [0002] Bioimaging techniques mainly include optical imaging, magnetic resonance imaging, ultrasound imaging and positron imaging, etc. Optical imaging has the characteristics of high sensitivity and short detection time, but it has limitations in deep tissue imaging. Magnetic resonance imaging can perform deep tissue imaging, but its sensitivity is low. Therefore, the two imaging techniques have good complementary advantages. Photoacoustic imaging is a new non-invasive imaging technology developed in recent years. Its principle is to use the principle of sound waves generated by thermal expansion after absorbing light energy. Compared with other optical i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/18A61K49/12
Inventor 张华娟宋亮
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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