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Complex hernia patch and preparing method and application thereof

A patch and outer layer technology, applied in the field of composite hernia patch and its preparation, can solve the problems of unstable product strength, unstable source, high abdominal tension, etc., to reduce infection and scar formation, good binding force, The effect of moderate suture strength

Inactive Publication Date: 2016-02-10
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its unstable source, the strength of the final product is also unstable, and it is difficult to withstand high abdominal pressure. After the cells grow in, the scaffold will gradually degrade, so the recurrence rate is much higher than that of artificial synthetic patches.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] In this embodiment, the composite hernia patch is prepared by the following method, which specifically includes the following steps:

[0047] (1) Soak the bovine bladder decellularized scaffold layer (Cook Biotechnology Company) in the sodium bicarbonate solution of pH=8 for 12h for pretreatment, and soak the polylactone mesh layer in the hydrochloric acid buffer solution of pH=5 20min for pretreatment;

[0048] (2) Spread the pretreated bovine bladder decellularized scaffold layer on a glass plate, place the pretreated polylactone mesh layer (Johnson & Johnson) on the bovine bladder decellularized scaffold layer, and then place the polylactone mesh layer on the polylactone mesh Place another pretreated bovine bladder decellularized scaffold layer on the sheet, and fix the two ends of the flat three-layer structure with the glass plate with rubber bands;

[0049] (3) Soak the three-layer structure fixed on the glass plate obtained in step (1) for 30 minutes in the imme...

Embodiment 2

[0051] In this embodiment, the composite hernia patch is prepared by the following method, which specifically includes the following steps:

[0052] (1) Soak the porcine small intestine decellularized scaffold layer (Cook Biotechnology Company) in the sodium bicarbonate solution of pH=10 for 6h for pretreatment, and soak the polylactone mesh layer in the hydrochloric acid buffer solution of pH=4 10min for pretreatment;

[0053] (2) Spread the pretreated bovine bladder decellularized scaffold layer on a glass plate, place the pretreated polylactone mesh layer on the porcine small intestine decellularized scaffold layer, and then place the polylactone mesh layer on the polylactone mesh layer Place another pretreated porcine small intestine decellularized scaffold layer, and fix the two ends of the flat three-layer structure with the glass plate with rubber bands;

[0054] (3) Soak the three-layer structure fixed on the glass plate obtained in step (1) for 10 minutes in the imme...

Embodiment 3

[0056] In this embodiment, the composite hernia patch is prepared by the following method, which specifically includes the following steps:

[0057] (1) Soak the porcine bladder decellularized scaffold layer (Cook Biotechnology Company) in the sodium bicarbonate solution of pH=9 for 10h for pretreatment, and soak the polylactone mesh layer in the hydrochloric acid buffer solution of pH=3 10min for pretreatment;

[0058] (2) Spread the pretreated porcine bladder decellularized scaffold layer on a glass plate, place the pretreated polylactone mesh layer on the porcine bladder decellularized scaffold layer, and then place the polylactone mesh layer on the polylactone mesh layer Place another pretreated porcine bladder decellularized scaffold layer, and fix the two ends of the flat three-layer structure with the glass plate with rubber bands;

[0059](3) Soak the three-layer structure fixed on the glass plate obtained in step (1) for 20 minutes in the immersion solution whose vol...

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Abstract

The invention provides a complex hernia patch and a preparing method and application thereof. The complex hernia patch comprises three layer structures which are an outer biological layer, an inner supporting layer and an outer biological layer from bottom to top respectively, wherein the outer biological layers are accellular stent layers, and the inner supporting layer is a polylactone mesh layer. The complex hernia patch prepared through the preparing method comprises the three layer structures, accellular stents in contact with tissue are located on the outer layers, cells can be induced to grow, and thus infection of a hernia coloboma part and formation of scars can be reduced; the polylactone mesh layer serves as the inner supporting layer so that the mechanical strength of the complex hernia patch can be maintained, the stability of the patch can be improved, and high abdomen expansion pressure can be borne; furthermore, the binding force of the inner layer and the outer layers is good, and thus the problems that due to the fact that the strength of an existing product is not stable, high abdomen expansion pressure cannot be borne, a stent is gradually degraded after cells grow into the stent, consequently tardive pain of hernia repair is brought, and relapse is likely to occur can be effectively solved; in addition, the preparing method is simple and capable of being applied to industrial production.

Description

technical field [0001] The invention belongs to the field of medicament preparation, and relates to a composite hernia patch, a preparation method and application thereof. Background technique [0002] Hernia repair patch is mainly used for the repair of abdominal wall hernia, which means that the organs or tissues in the abdominal cavity protrude from the weak area or defect of the abdominal wall. Abdominal wall hernia includes inguinal hernia, umbilical hernia, femoral hernia, incisional hernia and parastomal hernia, etc. Inguinal hernia (the junction of thigh and abdomen) is the most common. Because of the high incidence of abdominal wall hernia, its treatment has become an important social issue. [0003] Currently, hernia repair is the only option for healing abdominal wall hernias. Hernia repair refers to the surgical treatment of hernia, which can be divided into traditional hernia repair and hernia mesh tension-free repair. At present, tension-free repair has beco...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/50A61L27/54
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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