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Fenbendazole micro-capsules and preparation method thereof

A technology of fenbendazole microcapsules and fenbendazole, which is applied in the directions of microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of frequent medication, short elimination half-life, etc., and achieves improved fluidity and compressibility, reduced Incompatibility, effect of prolonging half-life

Active Publication Date: 2016-02-24
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the conventional dosage form of the drug has a short elimination half-life, frequent medication, and wide distribution in the body

Method used

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  • Fenbendazole micro-capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A fenbendazole microcapsule is prepared from the following raw materials in parts by weight: 1 part of fenbendazole, 2-6 parts of gum arabic, and 1-5 parts of gelatin.

[0022] The preparation method of fenbendazole microcapsules as described above comprises the following steps:

[0023] (1) Preparation of fenbendazole milk: Take 2-6 parts by weight of gum arabic and add it to 90-120 parts by weight of distilled water to dissolve, then add 1 part of fenbendazole and emulsify it in a tissue masher for 2-5 minutes, tissue The speed of the masher is 9000~12000r / min, standby;

[0024] (2) Preparation of gelatin solution: Take 1-5 parts by weight of gelatin and 100-140 parts by weight of distilled water to swell for 10-13 hours to make a sol, heat the sol at 45-60°C for 15-35 minutes, and filter to obtain a gelatin solution;

[0025] (3) Add the gelatin solution obtained in step (2) to the fenbendazole emulsion obtained in step (1), stir continuously, and add dropwise an ac...

Embodiment 2

[0028] The fenbendazole microcapsules provided by the invention are prepared from the following raw materials in parts by weight: 1 part of fenbendazole, 5 parts of gum arabic, and 5 parts of gelatin.

[0029] The above-mentioned fenbendazole microcapsules are prepared by the following steps.

[0030] (1) Preparation of fenbendazole milk: take 5g of gum arabic and add it to 100ml of distilled water to dissolve, then add 1g of fenbendazole and emulsify it in a tissue grinder for 3 minutes, the speed of the tissue grinder is 12000r / min, and set aside;

[0031] (2) Preparation of gelatin solution: Swell 5g gelatin and 100ml distilled water for 10 hours to make a sol, heat the sol at 50°C for 20 minutes, and filter to obtain a gelatin solution;

[0032] (3) Add the gelatin solution to the fenbendazole emulsion, stir continuously, and add dropwise acetic acid solution with a concentration of 15% by weight at 50°C to pH 3.9; stir and cool to 5°C in an ice-water bath, add weight 20m...

Embodiment 3

[0035] The fenbendazole microcapsules provided by the invention are prepared from the following raw materials in parts by weight: 1 part of fenbendazole, 5 parts of gum arabic, and 4 parts of gelatin.

[0036] The above-mentioned fenbendazole microcapsules are prepared by the following steps.

[0037] (1) Preparation of fenbendazole milk: Take 4 g of gum arabic and add it to 90 ml of distilled water to dissolve, then add 1 g of fenbendazole and emulsify in a tissue grinder for 4 minutes, the speed of the tissue grinder is 9000 r / min, and set aside;

[0038] (2) Preparation of gelatin solution: swell 4g gelatin and 120ml distilled water for 11 hours to make a sol, heat the sol at 55°C for 20 minutes, and filter to obtain a gelatin solution;

[0039] (3) Add the gelatin solution to the fenbendazole emulsion, stir continuously, and add dropwise acetic acid solution with a concentration of 15% by weight at 60°C to pH 4.1; stir and cool to 5°C in an ice-water bath, add weight Add ...

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Abstract

Disclosed are fenbendazole micro-capsules and a preparation method thereof. The preparation method includes, firstly, preparing fenbendazole emulsion and gelatin solution, adding the gelatin solution into the fenbendazole emulsion while stirring continuously until forming capsules, cooling by ice bath, adding in formaldehyde solution and sodium hydroxide solution to regulate pH value, standing the mixture until the mixture is in a layering state, removing supernatant, and then washing and drying to obtain finished products. The preparation method of fenbendazole micro-capsules is simple, is low in cost, easy to operate, low in loss and high in total yield; fenbendazole micro-capsules produced by the method are white or light-yellow or yellow spherical particles with the diameter ranging from 200 micrometers to 850 micrometers, are semi-transparent in microscope, are good in flowability and accordingly are easy to mix with food.

Description

technical field [0001] The invention discloses a fenbendazole microcapsule preparation and a preparation method thereof, belonging to the field of fenbendazole preparations. Background technique [0002] Fenbendazole is a benzimidazole anthelmintic drug, which not only has a high degree of anthelmintic activity against gastrointestinal nematodes and larvae, but also has good effects on Dictyocaulus, Fasciola and tapeworms, and has a strong killing effect. Insect egg effect; against Haemonchus sheep, Osteria, Trichostrongylus, Cooperis nematode, Leptostomum elegans, Chabert's nematode, esophageal mouth nematode, Trichocephala nematode, Dictyocerchus adult worms and The larvae are all highly effective; it has a good repelling effect on the extended Monitz tapeworm and the Monitz tapeworm. [0003] Common clinical dosage forms include oral dosage forms and injections. However, the elimination half-life of the conventional dosage form of the drug is short, the drug is frequent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/4184A61P33/10
CPCA61K9/50A61K31/4184A61K47/42
Inventor 李亚娥赵志刚
Owner ZHENGZHOU HOUYI PHARMA
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