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A kind of conjunctival sac flushing solution and preparation method thereof

A flushing solution and conjunctival sac technology, which is applied in the direction of pharmaceutical formula, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of irritation and low bactericidal effect, and achieve improved adhesion and protection Intraocular mucous membrane, the effect of reducing the difficulty of dispersion

Inactive Publication Date: 2018-07-06
孙维星
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the technical defects of the prior art, and provides a conjunctival sac flushing liquid and a preparation method thereof, so as to solve the technical problem of low bactericidal efficacy of the conjunctival sac flushing liquid in the prior art
[0005] Another technical problem solved by the present invention is that the conjunctival sac flushing liquid in the prior art is irritating to the eyes.

Method used

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  • A kind of conjunctival sac flushing solution and preparation method thereof
  • A kind of conjunctival sac flushing solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A conjunctival sac flushing solution, which is composed of the following ingredients in parts by weight: 0.5-3 parts of surfactant, 0.1 part of oligosaccharide, 0.1 part of bactericide, 0.1 part of auxiliary agent, 0.1 part of stabilizer, 0.1 part of moisturizing agent, 0.5 parts of Lulan polysaccharide, 0.2 parts of carboxymethyl cellulose, 1 part of aloe vera gel, 88.5 parts of purified water;

[0023] Wherein the surfactant is selected from sodium lauroyl sarcosinate; the oligosaccharide is selected from stachyose; the bactericide is selected from Kasone; the auxiliary agent is selected from lactic acid; Raw gum; the humectant is selected from glycerin.

[0024] The pH of the rinse solution was 6.5.

[0025] The viscosity of the flushing liquid is 10 mPa·s.

[0026] The above rinse solution was prepared by:

[0027] 1) Add the formulated amount of purified water into the stirred tank, then add the formulated amount of surfactant, and stir for 20 minutes until the ...

Embodiment 2

[0033] A conjunctival sac flushing solution, which is composed of the following ingredients in parts by weight: 0.5-3 parts of surfactant, 3 parts of oligosaccharide, 1 part of bactericide, 0.5 part of auxiliary agent, 1 part of stabilizer, 3 parts of moisturizing agent, 1 part of Lulan polysaccharide, 0.5 part of carboxymethyl cellulose, 1.2 parts of aloe vera gel, 99.5 parts of purified water;

[0034] Wherein the surfactant is selected from sodium cocoamphoacetate; the oligosaccharide is selected from lactulose; the bactericide is selected from glutaraldehyde; the auxiliary agent is selected from citric acid; From carbomer; the humectant is selected from hyaluronic acid.

[0035] The pH of the rinse solution was 6.8.

[0036] The viscosity of the flushing liquid is 30 mPa·s.

[0037] The above rinse solution was prepared by:

[0038] 1) Add the formulated amount of purified water into the stirred tank, then add the formulated amount of surfactant, and stir for 40 minutes...

Embodiment 3

[0044] A conjunctival sac flushing solution, consisting of the following components by weight: 1.8 parts of surfactant, 1.7 parts of oligosaccharide, 0.6 part of bactericide, 0.3 part of auxiliary agent, 0.5 part of stabilizer, 2.2 parts of moisturizing agent, pullulan 0.8 parts of polysaccharide, 0.3 parts of carboxymethyl cellulose, 1.1 parts of aloe vera gel, 94 parts of purified water;

[0045] Wherein the surfactant is selected from sodium cocoamphoacetate; the oligosaccharide is selected from xylooligosaccharide; the bactericide is selected from polyhexamethyleneguanidine; the auxiliary agent is selected from citric acid; The stabilizing agent is selected from ethylenediaminetetraacetic acid; the moisturizing agent is selected from squalane.

[0046] The above rinse solution was prepared by:

[0047] 1) Add the formulated amount of purified water into the stirred tank, then add the formulated amount of surfactant, and stir for 30 minutes until the surfactant is complete...

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Abstract

The invention provides a conjunctival sac flushing fluid and a preparation method thereof. A surfactant and and lipid components are added, so that the flushing fluid can dissolve foreign matter in a conjunctival sac and can be easily emulsified by water; under action of oligosaccharide, the flushing fluid has certain natural antibacterial effect. On this basis, a bactericide non-irritant to skin and mucosa is added, so that pathogenic microorganisms in the conjunctival sac can be killed more effectively. In addition, aloe gel playing a role in protecting the mucosa and pullulan and carboxymethyl cellulose which are used for enhancing drug adhesion effect are added, so that using effect of the flushing fluid is improved. In the method aspect, through optimized designing of component adding time, preparation efficiency is improved remarkably; an ultrasonic oscillation process is introduced, so that dispersing difficulty of the aloe gel is lowered remarkably and preparation time is reduced.

Description

technical field [0001] The invention relates to the technical field of eye care, in particular to a conjunctival sac flushing solution and a preparation method thereof. Background technique [0002] Conjunctival sac flushing is a routine operation in ophthalmic care. It is mostly used as cleaning and disinfection before ophthalmic surgery. Its function is to kill pathogenic microorganisms and reduce the risk of postoperative wound infection; Foreign bodies also need to be removed by irrigation of the conjunctival sac. Since avoiding intraocular infection is the most important prerequisite for ophthalmic surgery, the preoperative washing of the conjunctival sac should be completely sterilized as much as possible. However, with the widespread use of antibiotics in recent years, the drug susceptibility, Drug resistance has changed to varying degrees, so higher requirements are put forward for the bactericidal effect of conjunctival sac flushing fluid. In the prior art, 0.02% ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/56A61K31/11A61K31/785A61K47/36A61K47/38A61K47/26A61P27/02A61P31/04
CPCA61K9/0048A61K9/08A61K31/11A61K31/56A61K31/785A61K47/26A61K47/36A61K47/38
Inventor 孙维星
Owner 孙维星
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