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Preparation method of tablet for increasing bone density

A technology to increase bone density and red deer bone, which is applied in the field of preparation of bone density-enhancing tablets, can solve problems such as inability to perform high-speed tablet compression, drug safety risks, and unsatisfactory particle size distribution.

Inactive Publication Date: 2016-03-09
HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitation of traditional technology, the daily production capacity of this product is low and the content fluctuates greatly
The main reason is that the traditional high-concentration ethanol solution granulation preparation process is adopted for bone density-enhancing tablets. It reduces the safety of increasing the production of bone density tablets and brings hidden dangers to the safe production of enterprises
In addition, because the binder is added unevenly, the material is easy to agglomerate, and the particle size distribution is not ideal, resulting in large fluctuations in the tablet weight of the increased bone density tablet during high-speed compression, which in turn leads to an abnormal increase in the content fluctuation of the finished product, thus causing the product High-speed tablet pressing is not possible, and the daily production capacity is very low
Therefore, increasing the single-day production capacity of the traditional production and preparation process of high-concentration ethanol solution for bone density tablets cannot meet people's demand for this drug, and will bring greater risks to people's drug safety

Method used

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  • Preparation method of tablet for increasing bone density

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) Preliminary degreasing, crushing, intermediate degreasing, drying at 100°C, coarse crushing, fine degreasing, drying at 100°C, and crushing the red deer bone into fine powder to obtain fine powder A for use;

[0017] (2) Grinding hydrolyzed collagen, calcium carbonate, sodium chondroitin sulfate, casein phosphopeptide, hydroxypropyl cellulose, lactose, and sodium starch glycolate into fine powders respectively, and set aside;

[0018] (3) 0.5g of casein phosphopeptide fine powder and 15g of sodium chondroitin sulfate fine powder are mixed evenly by the method of equal increments to obtain fine powder B, which is set aside;

[0019] (4) Weigh 55g of hydrolyzed collagen fine powder, 65g of fine powder A, 160g of calcium carbonate fine powder, and 15.5g of fine powder B, add the remaining auxiliary materials, put them into a mixer and mix evenly to obtain material C, and set aside;

[0020] (5) Put the obtained material C in a one-step granulator, and feed clean compre...

Embodiment 2

[0024] (1) Preliminary degreasing, crushing, intermediate degreasing, drying at 100°C, coarse crushing, fine degreasing, drying at 100°C, and crushing the red deer bone into fine powder to obtain fine powder A for use;

[0025] (2) Grinding hydrolyzed collagen, calcium carbonate, sodium chondroitin sulfate, casein phosphopeptide, hydroxypropyl cellulose, lactose, and sodium starch glycolate into fine powders respectively, and set aside;

[0026] (3) 1.8g of casein phosphopeptide fine powder and 20g of sodium chondroitin sulfate fine powder were mixed evenly by the method of equal increments to obtain fine powder B, which was set aside;

[0027] (4) Weigh 60g hydrolyzed collagen fine powder, 70g fine powder A, 180g calcium carbonate fine powder, 21.8g fine powder B, add remaining auxiliary materials, put into the mixer and mix evenly to obtain material C, set aside;

[0028] (5) Put the obtained material C in a one-step granulator, and feed clean compressed air into the pressur...

Embodiment 3

[0032] (1) Preliminary degreasing, crushing, intermediate degreasing, drying at 100°C, coarse crushing, fine degreasing, drying at 100°C, and crushing the red deer bone into fine powder to obtain fine powder A for use;

[0033] (2) Grinding hydrolyzed collagen, calcium carbonate, sodium chondroitin sulfate, casein phosphopeptide, hydroxypropyl cellulose, lactose, and sodium starch glycolate into fine powders respectively, and set aside;

[0034] (3) 2.0g of casein phosphopeptide fine powder and 22g of sodium chondroitin sulfate fine powder are mixed evenly by the method of equal increments to obtain fine powder B, which is set aside;

[0035] (4) Weigh 70g of hydrolyzed collagen fine powder, 80g of fine powder A, 200g of calcium carbonate fine powder, and 24.0g of fine powder B, add the remaining auxiliary materials, put them into a mixer and mix evenly to obtain material C, and set aside;

[0036] (5) Put the obtained material C in a one-step granulator, and feed clean compre...

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Abstract

The invention discloses a preparation method of a tablet for increasing the bone density. The table is mainly composed of red deer bone, calcium carbonate, hydrolyzed collagen, and sodium chondroitin sulfate. A boiling one-step granulation method is adopted. Three steps: mixing, granulation, and drying are carried out in a boiling enclosed chamber at a time. The prepared particles are uniform, the fluidity is good, the weight difference is small, and the dissolution rate is good. Compared with the conventional wet process granulation technology, the provided method has the advantages of fewer steps, less production equipment, higher safety, more output, and shorter production period, and the quality of obtained product is stable and controllable.

Description

technical field [0001] The invention relates to a health food for increasing bone density and a preparation method thereof, in particular to a preparation method for bone density increasing tablets. Background technique [0002] Studies have shown that people reach the peak of bone accumulation around the age of 30, that is, the formation of the peak bone in a person's life. Later, with the increase of age, bone resorption is greater than bone formation, which is manifested as a progressive decrease in bone density. With the gradual acceleration of the pace of modern life, the pressure of work and life is gradually increasing, and the modern population lacks physical exercise, coupled with bad habits such as smoking and drinking, leading to younger ages at which bone density begins to decrease. Osteoporosis is the most common disease caused by decreased bone mineral density. Osteoporosis is a common, systemic bone disease that reduces bone mass and changes the microstructure...

Claims

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Application Information

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IPC IPC(8): A23L33/00A23P10/28
CPCA23V2002/00
Inventor 芦传有赵冬艳范宁张红梅董立财褚利娟俄丽丹
Owner HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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