Preparation method of tablet for increasing bone density

A technology to increase bone density and red deer bone, which is applied in the field of preparation of bone density-enhancing tablets, can solve problems such as inability to perform high-speed tablet compression, drug safety risks, and unsatisfactory particle size distribution.

Inactive Publication Date: 2016-03-09
HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitation of traditional technology, the daily production capacity of this product is low and the content fluctuates greatly
The main reason is that the traditional high-concentration ethanol solution granulation preparation process is adopted for bone density-enhancing tablets. It reduces the safety of increasing the production of bone density tablets and brings hidden dangers to the safe production of enterprises
In addition, because the binder is added unevenly, the material is easy to agglomerate, and the particle size distribution is not ideal, resulting in larg

Method used

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  • Preparation method of tablet for increasing bone density

Examples

Experimental program
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Effect test

Example Embodiment

[0015] Example 1

[0016] (1) After initial degreasing, crushing, medium degreasing, drying at 100°C, coarse crushing, fine degreasing, and drying at 100°C, the red deer bones are pulverized into fine powder to obtain fine powder A for use;

[0017] (2) Crush the hydrolyzed collagen, calcium carbonate, sodium chondroitin sulfate, casein phosphopeptide, hydroxypropyl cellulose, lactose, and sodium starch glycolate into fine powders for use;

[0018] (3) Mix 0.5g casein phosphopeptide fine powder and 15g chondroitin sulfate sodium fine powder in equal increments to obtain fine powder B for use;

[0019] (4) Weigh 55g of hydrolyzed collagen powder, 65g of fine powder A, 160g of fine calcium carbonate powder, and 15.5g of fine powder B, add the remaining auxiliary materials, put them in the mixer and mix evenly to obtain material C for use;

[0020] (5) Place the obtained material C in a one-step granulator, and pass clean compressed air into the pressure tank of the one-step granulator. In...

Example Embodiment

[0023] Example 2

[0024] (1) After initial degreasing, crushing, medium degreasing, drying at 100°C, coarse crushing, fine degreasing, and drying at 100°C, the red deer bones are pulverized into fine powder to obtain fine powder A for use;

[0025] (2) Crush the hydrolyzed collagen, calcium carbonate, sodium chondroitin sulfate, casein phosphopeptide, hydroxypropyl cellulose, lactose, and sodium starch glycolate into fine powders for use;

[0026] (3) Mix 1.8g casein phosphopeptide fine powder and 20g chondroitin sulfate sodium fine powder in equal increments to obtain fine powder B for use;

[0027] (4) Weigh 60g of hydrolyzed collagen powder, 70g of fine powder A, 180g of fine calcium carbonate powder, and 21.8g of fine powder B, add the remaining auxiliary materials, put them in the mixer and mix evenly to obtain material C for use;

[0028] (5) Put the obtained material C in a one-step granulator, and pass clean compressed air into the pressure tank of the one-step granulator. In t...

Example Embodiment

[0031] Example 3

[0032] (1) After initial degreasing, crushing, medium degreasing, drying at 100°C, coarse crushing, fine degreasing, and drying at 100°C, the red deer bones are pulverized into fine powder to obtain fine powder A for use;

[0033] (2) Crush the hydrolyzed collagen, calcium carbonate, sodium chondroitin sulfate, casein phosphopeptide, hydroxypropyl cellulose, lactose, and sodium starch glycolate into fine powders for use;

[0034] (3) Mix 2.0 g casein phosphopeptide fine powder and 22 g chondroitin sulfate sodium fine powder in equal increments to obtain fine powder B for use;

[0035] (4) Weigh 70g of hydrolyzed collagen powder, 80g of fine powder A, 200g of fine calcium carbonate powder, and 24.0g of fine powder B, add the remaining auxiliary materials, put them in the mixer and mix evenly to obtain material C for use;

[0036] (5) Place the obtained material C in a one-step granulator, and pass clean compressed air into the pressure tank of the one-step granulator. ...

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Abstract

The invention discloses a preparation method of a tablet for increasing the bone density. The table is mainly composed of red deer bone, calcium carbonate, hydrolyzed collagen, and sodium chondroitin sulfate. A boiling one-step granulation method is adopted. Three steps: mixing, granulation, and drying are carried out in a boiling enclosed chamber at a time. The prepared particles are uniform, the fluidity is good, the weight difference is small, and the dissolution rate is good. Compared with the conventional wet process granulation technology, the provided method has the advantages of fewer steps, less production equipment, higher safety, more output, and shorter production period, and the quality of obtained product is stable and controllable.

Description

technical field [0001] The invention relates to a health food for increasing bone density and a preparation method thereof, in particular to a preparation method for bone density increasing tablets. Background technique [0002] Studies have shown that people reach the peak of bone accumulation around the age of 30, that is, the formation of the peak bone in a person's life. Later, with the increase of age, bone resorption is greater than bone formation, which is manifested as a progressive decrease in bone density. With the gradual acceleration of the pace of modern life, the pressure of work and life is gradually increasing, and the modern population lacks physical exercise, coupled with bad habits such as smoking and drinking, leading to younger ages at which bone density begins to decrease. Osteoporosis is the most common disease caused by decreased bone mineral density. Osteoporosis is a common, systemic bone disease that reduces bone mass and changes the microstructure...

Claims

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Application Information

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IPC IPC(8): A23L33/00A23P10/28
CPCA23V2002/00
Inventor 芦传有赵冬艳范宁张红梅董立财褚利娟俄丽丹
Owner HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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