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A kind of preparation method of submicron emulsion with improving effect on atopic dermatitis

A submicron technology for atopic dermatitis, applied in medical preparations containing active ingredients, skin care preparations, skin diseases, etc., can solve the problems of many side effects, achieve good stability, maintain skin microecology, The effect of increasing the moisture content of the epidermis

Active Publication Date: 2018-04-17
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If one molecule of sphingosine and one molecule of behenic acid are used to synthesize ultra-long carbon chain ceramide, its melting point is expected to exceed 140°C. Ultra-long carbon chain ceramide synthesized by the reaction of aminoalcohol and a molecule of behenic acid

Method used

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  • A kind of preparation method of submicron emulsion with improving effect on atopic dermatitis
  • A kind of preparation method of submicron emulsion with improving effect on atopic dermatitis
  • A kind of preparation method of submicron emulsion with improving effect on atopic dermatitis

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Effect test

Embodiment 1

[0039] A method for preparing a submicron emulsion with improved efficacy for atopic dermatitis, comprising the following steps:

[0040] A: Weigh 500g white pond flower seed oil, 300g behenic acid, 500g ceramide III, 100g D~galactose, 30g potassium hydroxide, 1000g deionized water according to the mass ratio of 5:3:5:1:0.3:10 into the stainless steel reactor;

[0041] B: Fill the stainless steel reaction kettle with nitrogen for protection, the temperature in the kettle is controlled at 120°C, and the pressure is 1.2kgf / cm 2 , the reaction time is 2 hours, and 15rpm scraping and stirring are kept during the reaction;

[0042] C: Take a small amount of reactant product and analyze it by chromatographic analysis. The content of ceramide III of behenic acid group in the reaction product is higher than 2%, the content of galactosylceramide is higher than 1%, and the reaction is completed; then the stainless steel The temperature in the reaction kettle is warmed to 75°C, and the...

Embodiment 2

[0046] A method for preparing a submicron emulsion with improved efficacy for atopic dermatitis, comprising the following steps:

[0047] A: Weigh 500g white pond flower seed oil, 300g behenic acid, 700g ceramide III, 200g trehalose, 40g potassium hydroxide, 1000g deionized water into stainless steel according to the mass ratio 5:3:7:2:0.4:10 In the reactor;

[0048] B: Fill the stainless steel reaction kettle with nitrogen for protection, the temperature in the kettle is controlled at 130°C, and the pressure is 1.8kgf / cm 2 , the reaction time is 3 hours, and 15rpm scraping and stirring are kept during the reaction;

[0049] C: Take a small amount of reactant product and analyze it by chromatographic analysis. The content of ceramide III of behenic acid group in the reaction product is higher than 2%, the content of trehalose ceramide is higher than 1%, and the reaction is completed; then stainless steel The temperature in the reaction kettle is warmed to 80°C, and the press...

Embodiment 3

[0053] A method for preparing a submicron emulsion with improved efficacy for atopic dermatitis, comprising the following steps:

[0054] A: Weigh 800g white pond flower seed oil, 400g behenic acid, 1000g ceramide III, 300g rhamnose, 50g potassium hydroxide, 2000g deionized water according to the mass ratio of 8:4:10:3:0.5:20 In a stainless steel reaction kettle; during the reaction process, keep scraping and stirring at 15rpm;

[0055] B: Fill the stainless steel reaction kettle with nitrogen for protection, the temperature in the kettle is controlled at 120°C, and the pressure is 1.4kgf / cm 2 , the reaction time is 4 hours, and 15rpm scraping and stirring are kept during the reaction process;

[0056] C: Take a small amount of reactant product and analyze it by chromatographic analysis. The content of ceramide III of behenic acid group in the reaction product is higher than 2%, the content of rhamnosylceramide is higher than 1%, and the reaction is completed; then The tempe...

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Abstract

A preparation method of submicron emulsion with an improvement effect on atopic dermatitis is characterized by adopting the following steps: A: weighing meadowfoam seed oil, behenic acid, ceramide III synthetized by sphingol and oleic acid, saccharides, a catalyst and deionized water according to a mass ratio, and putting into a stainless steel reaction still; B: reacting for 2-4 hours at a temperature of 120 DEG C-140 DEG C and a pressure of 1.2-1.8kgf / cm<2>; C: considering that the reaction is completed when super-long carbon chain ceramide is higher than 2 percent and glycosyl ceramide is higher than 1 percent in a reaction product; D: adding hydrogenated lysolecithin, cholesterol and deionized water, and stirring for 0.5-1 hour at a temperature of 75-90 DEG C, thus forming a uniform emulsion; E, performing three times of high pressure homogenization on the emulsion obtained in step D by using a high pressure homogenizer at 75-90 DEG C and a pressure of 1500-2500 bar, and cooling to room temperature, thus obtaining the submicron emulsion with the improvement effect on atopic dermatitis. The submicron emulsion obtained by the preparation method has the beneficial effect of being capable of improving atopic dermatitis skin conditions.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a method for preparing a submicron emulsion with improved efficacy on atopic dermatitis. technical background [0002] Atopic Dermatitis, referred to as AD, is a common recurrent inflammatory skin disease. The main symptoms are severe itching, eczema-like skin lesions, xeroderma, etc., which seriously affect the quality of life of patients. The study found that there are several phenomena in the skin of patients with atopic dermatitis compared with normal skin: 1) The lipid content of the skin surface decreases, resulting in a decrease in the moisture content of the epidermis, and the destruction of the normal microbial flora on the skin surface, and the resident beneficial bacteria Compared with normal skin, the amount is significantly reduced; 2) The intercellular lipid content decreases, resulting in a decrease in the skin barrier function. As the main component of the skin ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/68A61K8/06A61Q19/00A61P17/00
CPCA61K8/068A61K8/68A61K8/922A61K2800/10A61K2800/412A61K2800/596A61Q19/00
Inventor 张金龙毕永贤王丽娜蒋丽刚
Owner PROYA COSMETICS