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A kind of self-emulsifying coenzyme q10 oil agent and its preparation method and application

An emulsifier and self-emulsifying technology, which is applied in the digestive system, pharmaceutical formulations, oil/fat/wax non-effective ingredients, etc., can solve the problems of bioavailability without clear instructions, small solubility and easy crystallization, and product Technical defects and other problems, to achieve the effect of being conducive to preparation and preservation, simple preparation method, and improved absorption rate

Active Publication Date: 2018-11-09
XIAMEN KINGDOMWAY BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In today's numerous patents about the content and self-emulsification used in soft capsules, most of them use a single oil agent, and there are more or less some defects: CN201310116545.4 "A Coenzyme Q10 Soft Capsule and Its "Preparation Method" mentions the raw material ratio and preparation method for the preparation of the contents of coenzyme Q10 soft capsules. Due to the solubility of coenzyme Q10, it is necessary to add beeswax to the contents as a suspension to maintain the uniformity of the materials.
[0005] Summarizing the problems existing in the above existing patents, some of them come from the raw materials themselves, such as the good health effects of coenzyme Q10. Now there are a large number of coenzyme Q10 soft capsules on the market, but most of these capsules use relatively simple vegetable oils, such as soybean oil, Most of them are corn oil and sunflower oil, which are only used as auxiliary dissolving oil agents, and have a single effect. For example, the small solubility of coenzyme Q10 itself in vegetable oil and the characteristics of easy precipitation and crystallization restrict the increase of product content; others are products There are technical deficiencies, such as no clear instructions on bioavailability

Method used

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  • A kind of self-emulsifying coenzyme q10 oil agent and its preparation method and application
  • A kind of self-emulsifying coenzyme q10 oil agent and its preparation method and application
  • A kind of self-emulsifying coenzyme q10 oil agent and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of coenzyme Q10 and DHA self-emulsifying oil (can compress 1000,000 soft capsules containing 50mg of coenzyme Q10 and 100mg of DHA)

[0040] Coenzyme Q10: 50kg

[0041] DHA oil: 225kg

[0042] THL-15: 2.5kg

[0043] Ascorbyl palmitate: 9kg

[0044] Span 80: 10kg

[0045] Tween 80: 138.5kg

[0046] Poloxamer 168: 15kg

[0047] By weighing the components with the above weight, prepare coenzyme Q10 and DHA self-micronizing oil according to the following operations: add coenzyme Q10 and olive oil to DHA oil, then add oil phase emulsifier Span 80 and functional additive THL -15, avoid light, evacuate and replenish nitrogen for three times, heat and stir until the solid material is completely dissolved; then add the main emulsifier Tween 80 and Poloxamer 168. Heat at 60-65°C and stir until the final system is uniform and transparent, then keep warm for 10-30 minutes, and the final product can be obtained after cooling down. The final product obtained is an ...

Embodiment 2

[0049] Preparation of coenzyme Q10 and DHA self-emulsifying oil (can compress 1000,000 soft capsules containing coenzyme Q10 100mg, DHA 200mg No. 18 soft capsules), prepared coenzyme Q10 and DHA self-emulsifying oil by the same operation as described in Example 1 , but the following self-emulsifying system components are used.

[0050] Coenzyme Q10: 100kg

[0051] DHA oil: 400kg

[0052] THL-15: 5kg

[0053] Ascorbyl palmitate: 15kg

[0054] Span 80: 20kg

[0055] Tween 80: 240kg

[0056] Poloxamer 188: 20kg

[0057] The final product obtained is an orange-red transparent and uniform oil, which can be used as the content of microcapsules. Coenzyme Q10 / DHA soft capsules are obtained through soft capsule production equipment, and 1,000,000 No. 18 soft capsules can be prepared from the above-mentioned total content. Among them, the No. 18 soft capsule contains 800 mg of content, 100 mg of coenzyme Q10, and 200 mg of DHA (the content of coenzyme Q10 is determined by the met...

Embodiment 3

[0059] Preparation of coenzyme Q10 and ARA self-emulsifying oil (can compress 1000,000 soft capsules containing 50 mg of coenzyme Q10 and No. 100 mg of ARA), and prepare coenzyme Q10 and ARA self-emulsifying oil by the same operation as described in Example 1 , but the following self-emulsifying system components are used.

[0060] Coenzyme Q10: 50kg

[0061] ARA oil: 225kg

[0062] THL-17: 3kg

[0063] Ascorbyl palmitate: 9kg

[0064] Glyceryl monostearate: 15kg

[0065] Polyoxyethylene hydrogenated castor oil fatty acid ester: 133kg

[0066] Poloxamer 168: 15kg

[0067] The final product obtained is an orange-red transparent and uniform oil, which can be used as the content of microcapsules. Coenzyme Q10 / ARA soft capsules are obtained through soft capsule production equipment, and the above-mentioned total content can be used to prepare 1,000,000 No. 10 soft capsule products. The No. 10 soft capsule contains 450mg of content, 50mg of coenzyme Q10, and 100mg of ARA (th...

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Abstract

The invention discloses self-emulsifying coenzyme Q10 oil and a preparation method thereof. The oil is prepared from the following components in percentage by weight: 5-30 percent of coenzyme Q10, 10-55 percent of functional oil, less than or equal to 10 percent and more than 0 of an oil-phase emulsifying agent, 15-55 percent of a main body emulsifying agent and 0.2-10 percent of an oil-phase crystallization inhibitor, and the components are interacted, so that the oil can be stably dispersed in water and oil systems, can be self-emulsified in an aqueous phase to form transparent nano emulsion, has a high absorbability for human bodies, and has a high bioavailability.

Description

technical field [0001] The invention belongs to the technical field of health care products, and in particular relates to a self-emulsifying coenzyme Q10 oil and its preparation method and application. Background technique [0002] Coenzyme Q10 (Coenzyme Q10, CoQ10) is also known as decenoquinone and ubiquinone, and its chemical name is 2,3-dimethoxy-5-methyl-6-decyl isopentenyl-1,4-benzoquinone , is a fat-soluble natural vitamin substance that exists in a variety of organisms. It is a natural antioxidant produced by the cells itself, which can improve the immunity of the organism. In recent years, it has been widely used in various heart diseases, diabetes, and cancer. , the treatment of acute and chronic hepatitis, Parkinson's disease and other diseases, and can prevent arteriosclerosis, stroke and high blood pressure, and has a good health care effect on the heart, liver and kidneys. Clinical studies have shown that oral administration of coenzyme Q10 has a significant e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/122A61K47/44A61K47/14A61P9/00A61P3/10A61P35/00A61P1/16A61P25/16A61P9/10A61P9/12A61P25/28
Inventor 陈中科林木荣朱林静魏初权刘锦洪
Owner XIAMEN KINGDOMWAY BIOTECH CO LTD
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