Preparation method of secnidazole and dexamethasone oral sustained-release medicine membrane

A technology of secnidazole and dexamethasone, applied in the field of medicine, can solve problems such as poor clinical curative effect, and achieve the effects of low manufacturing cost, exact curative effect and stable quality

Inactive Publication Date: 2016-04-13
张庆峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are more and more patients with oral ulcers, periodontitis, and pericoronitis. Although there are many kinds of drugs for the treatment of oral ulcers, periodontitis, and pericoronitis, the clinical efficacy is not good and cannot meet the needs of patients. Need a kind of medicine with good curative effect for treating stomatitis

Method used

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  • Preparation method of secnidazole and dexamethasone oral sustained-release medicine membrane

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Experimental program
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Effect test

Embodiment 1

[0022] A kind of preparation method of secnidazole, dexamethasone oral sustained-release drug film, comprises the following steps:

[0023] 1) Weigh 1 part of secnidazole, 0.2 part of dexamethasone acetate, 3 parts of chitosan, 1 part of gelatin, 6 parts of glycerin, 10 parts of ethanol, 10 parts of dilute acetic acid, and about 80 parts of water for injection according to parts by weight ;

[0024] 2) Add chitosan to water for injection, add dilute acetic acid dropwise, and stir to dissolve into a transparent colloidal solution;

[0025] 3) Add glycerin and gelatin to the above-mentioned transparent colloidal solution, add water for injection, stir in a water bath at 30-40°C to fully swell and dissolve, and obtain a blank drug film colloidal solution;

[0026] 4) add secnidazole and dexamethasone acetate to ethanol, stir to make secnidazole and dexamethasone acetate dissolve completely, form ethanol solution;

[0027] 5) Put the mixed solution in a water bath at 30-40°C, ke...

Embodiment 2

[0032] A kind of preparation method of secnidazole, dexamethasone oral sustained-release drug film, comprises the following steps:

[0033] 1) Weigh 1 part of secnidazole, 0.3 part of dexamethasone acetate, 4 parts of chitosan, 1.2 parts of gelatin, 6 parts of glycerin, 9 parts of ethanol, 10 parts of dilute acetic acid, and about 90 parts of water for injection according to parts by weight ;

[0034] 2) Add chitosan to water for injection, add dilute acetic acid dropwise, and stir to dissolve into a transparent colloidal solution;

[0035] 3) Add glycerin and gelatin to the above-mentioned transparent colloidal solution, add water for injection, stir in a water bath at 30-40°C to fully swell and dissolve, and obtain a blank drug film colloidal solution;

[0036] 4) add secnidazole and dexamethasone acetate to ethanol, stir to make secnidazole and dexamethasone acetate dissolve completely, form ethanol solution;

[0037] 5) Put the mixed solution in a water bath at 30-40°C, ...

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Abstract

The invention discloses a secnidazole and dexamethasone oral sustained-release medicine membrane. The secnidazole and dexamethasone oral sustained-release medicine membrane is prepared from the following raw materials in parts by weight: 0.5-1 part of secnidazole, 0.1-0.3 part of dexamethasone acetate, 2-4 parts of chitosan, 1-1.5 parts of gelatin, 4-6 parts of glycerol, 9-10 parts of ethanol, 10 parts of dilute acetic acid and about 80-100 parts of water for injection. The invention also discloses a preparation method of the secnidazole and dexamethasone oral sustained-release medicine membrane. The preparation method has the following advantages: the process is simple, the prepared secnidazole and dexamethasone oral sustained-release medicine membrane is stable in quality, convenient to use, definite in curative effect and low in manufacturing cost, has a good curative effect on treating oral inflammation and therefore is worthy of popularization.

Description

Technical field: [0001] The invention relates to a preparation method of an oral sustained-release drug film of secnidazole and dexamethasone, which belongs to the technical field of medicine. Background technique: [0002] Oral ulcer, commonly known as "oral sore", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks stratum corneum. or poor keratosis. Tongue ulcers refer to oral ulcers that occur on the tongue and the abdomen of the tongue. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. [0003] Periodontitis is the most common disease in the oral cavity, and the prevalence rate among adults is as high as 90%. Periodontal disease ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K9/00A61K9/70A61P1/02A61K31/4164
CPCA61K31/573A61K9/0002A61K9/006A61K9/0063A61K9/7015A61K31/4164A61K47/42A61K2300/00
Inventor 张庆峰
Owner 张庆峰
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