Preparation method of co-loaded daunorubicin and gambogic acid cdte quantum dot nano-drug loading system

A technology of daunorubicin and nano-drug loading, which is applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the goals of reducing dosage, good dispersibility, and prolonging the action time Effect

Active Publication Date: 2018-12-28
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Current drug carriers mainly include nanocarriers, liposome carriers, microparticle carriers, biocarriers, etc., but there is no report on the combination of daunorubicin, gambogic acid and drug carriers

Method used

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  • Preparation method of co-loaded daunorubicin and gambogic acid cdte quantum dot nano-drug loading system
  • Preparation method of co-loaded daunorubicin and gambogic acid cdte quantum dot nano-drug loading system
  • Preparation method of co-loaded daunorubicin and gambogic acid cdte quantum dot nano-drug loading system

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Experimental program
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Embodiment 1

[0037] A preparation method of a co-loaded daunorubicin and gambogic acid CdTe quantum dot nano drug-loading system is characterized in that the method comprises the following steps:

[0038] (1) Functional modification of cadmium telluride (CdTe) with polymer polyethylene glycol (PEG): use 0.23 mmol of Al 2 Te 3 and 15 mL of 0.5 M H 2 SO 4 The reaction produces H 2 Te standby; 2.3mmol of Cd (ClO 4 ) 2 •H 2 O was dissolved in 125 mL of ultrapure water, and 5.5 mmol of cysteamine hydrochloride (Cys) was added dropwise under stirring conditions, then the pH value was adjusted to 5.9, and Ar gas was introduced for 30 min, and then added dropwise to obtain H 2 Te, the mixture was refluxed for 10 min to 9 h to control the growth of CdTe quantum dots, and finally added 1.84 mmol of high molecular polymer polyethylene glycol (PEG), and reacted for 24 h to obtain a modified cadmium telluride (CdTe) solution ;

[0039] (2) Dissolve daunorubicin (DNR) with a concentration of 10...

Embodiment 2

[0042] A preparation method of a co-loaded daunorubicin and gambogic acid CdTe quantum dot nano drug-loading system is characterized in that the method comprises the following steps:

[0043] (1) Functional modification of cadmium telluride (CdTe) with polymer polyethylene glycol (PEG): use 0.23 mmol of Al 2 Te 3 and 15 mL of 0.5 M H 2 SO 4 The reaction produces H 2 Te standby; 2.3mmol of Cd (ClO 4 ) 2 •H 2 O was dissolved in 125 mL of ultrapure water, and 5.5 mmol of cysteamine hydrochloride (Cys) was added dropwise under stirring conditions, then the pH value was adjusted to 5.9, and Ar gas was introduced for 30 min, and then added dropwise to obtain H 2 Te, the mixture was refluxed for 10 min to 9 h to control the growth of CdTe quantum dots, and finally added 1.84 mmol of high molecular polymer polyethylene glycol (PEG), and reacted for 24 h to obtain a modified cadmium telluride (CdTe) solution ;

[0044] (2) Dissolve daunorubicin (DNR) with a concentration of 50...

Embodiment 3

[0047] A preparation method of a co-loaded daunorubicin and gambogic acid CdTe quantum dot nano drug-loading system is characterized in that the method comprises the following steps:

[0048] (1) Functional modification of cadmium telluride (CdTe) with polymer polyethylene glycol (PEG): use 0.23 mmol of Al 2 Te 3 and 15 mL of 0.5 M H 2 SO 4 The reaction produces H 2 Te standby; 2.3mmol of Cd (ClO 4 ) 2 •H 2 O was dissolved in 125 mL of ultrapure water, and 5.5 mmol of cysteamine hydrochloride (Cys) was added dropwise under stirring conditions, then the pH value was adjusted to 5.9, and Ar gas was introduced for 30 min, and then added dropwise to obtain H 2 Te, the mixture was refluxed for 10 min to 9 h to control the growth of CdTe quantum dots, and finally added 1.84 mmol of high molecular polymer polyethylene glycol (PEG), and reacted for 24 h to obtain a modified cadmium telluride (CdTe) solution ;

[0049] (2) Dissolve daunorubicin (DNR) with a concentration of 30...

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Abstract

The invention discloses a preparation method of a CdTe quantum dot nanometer medicine carrying system carrying daunorubicin and gambogic acid, and relates to a preparation technology of a nanometer medicine carrying system carrying antitumor drugs and tumor multidrug resistance reversal drugs. The method comprises the steps that functional modification is conducted on CdTe through high-molecular polymer polyethylene glycol; BMPH is dropwise added in a DMF solution for dissolving daunorubicin, a stirring reaction is conducted at room temperature, and DNR carbamyl maleimide is obtained; a modified CdTe solution is added for conducting oscillating incubation, filtration and purification are conducted, and a PH sensitive novel medicine carrying system CdTe-DNR is obtained; a CdTe-DNR solution and a gambogic acid (GA) solution are mixed according to a certain proportion, after a reaction in a dark place is conducted, centrifugation is conducted, precipitation is washed through water, and the CdTe quantum dot nanometer medicine carrying system carrying daunorubicin and gambogic acid is obtained.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a preparation method of a co-loaded daunorubicin and gambogic acid CdTe quantum dot nanometer drug-loading system. Background technique [0002] Tumor is a major disease that seriously threatens human health. The current treatment methods mainly include surgery, chemotherapy, radiotherapy and targeted therapy. Patients with malignant tumors often receive chemotherapy before and after surgery, and some advanced patients are not feasible for surgical treatment. Therefore, chemotherapy still plays a very important role in tumor treatment. However, according to statistics from the American Cancer Society, more than 90% of cancer patients die due to tumor multidrug resistance. Multidrug resistance is an important cause of chemotherapy failure. Therefore, preventing and reversing clinical tumor multidrug resistance is crucial to improving The efficacy of chemotherapy is very import...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/60A61K31/704A61K31/352A61P35/00
CPCA61K31/352A61K31/704A61K2300/00
Inventor 许佩佩左华芹周敏汪帆陈兵
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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