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A fast ionization method and device

An ionization and rapid technology, applied in the field of mass spectrometry analysis, can solve the problems of high analysis and test cost, difficult compound analysis, complex experimental equipment, etc., and achieve the effect of shortening analysis time, fast in-situ analysis, and simplifying sampling operation.

Active Publication Date: 2017-12-19
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although DART has the advantages of fast operation and no need for solvents, there are still some defects in DART itself.
For example, the temperature adjustment range of DART is small, usually at 50-550°C, so it can detect mostly small molecules, and some macromolecular compounds are not easy to analyze; at the same time, DART usually uses helium as the ionization gas, and helium The cost of DART is very high, which makes the cost of analysis and testing very high. At the same time, the experimental device of DART is very complicated, and the operation is also relatively complicated.

Method used

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  • A fast ionization method and device
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  • A fast ionization method and device

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Experimental program
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Effect test

Embodiment 1

[0033] Such as figure 1 Shown: a kind of rapid ionization device provided by the present invention, comprises sample container 1, mass spectrometry sampling channel 2 and thermal energy generating device 3, the open end 12 of described sample container 1 is positioned on the axis of mass spectrometry sampling channel 2, so The thermal energy generating device 3 is arranged at the bottom 11 of the sample container 1 .

[0034] The distance d between the opening end 12 of the sample container 1 and the mass spectrometry sampling channel 2 can be 1-100 mm.

[0035] The thermal energy generating device 3 can be an electric heating device (such as a hair dryer, an electric air gun, an electric soldering iron, a heating wire, etc.) or a flame generating device (such as including a fuel storage tank and a delivery pipe).

[0036] The sample container is made of high-temperature-resistant materials, such as: high-temperature-resistant carbon fiber, alumina-magnesia brick, alloy or gl...

Embodiment 2

[0042] Will figure 1 The fast ionization device shown is combined with mass spectrometer (mass analyzer is Fourier transform ion cyclotron resonance), for the alkaloid compound quinine (Quinine, MW=324): Perform mass spectrometry:

[0043] Heat energy is provided by the heating of the hair dryer;

[0044] First, directly add 2 to 5 μg of solid sample quinine into the sample container 1 (10 mL high-temperature-resistant glass tube), then make the open end 12 of the sample container 1 be positioned on the axis of the mass spectrometry sampling channel 2, and make the hair dryer blow to the sample container 1 The bottom 11 of the sample container 1 is continuously heated, and the mass analyzer is always in the collection state; because the sample 4 located at the bottom 11 of the sample container 1 can produce rapid eruption under the action of the provided thermal energy, thereby ionization occurs.

[0045] image 3 For the mass spectrum obtained by image 3 The mass spectr...

Embodiment 3

[0047] Will figure 1 The fast ionization device shown is combined with a mass spectrometer (mass analyzer is Fourier transform ion cyclotron resonance), p-phenylalanamide-phenylalanine (H-PHE-PHE-OH, MW=312): Perform mass spectrometry:

[0048] Heat energy is provided by the heating of the electric soldering iron;

[0049] First, use ethanol to prepare the sample H-PHE-PHE-OH into a sample solution of about 0.1 mg / mL, then pipette 1-10 μL into sample container 1 (10 mL high-temperature-resistant glass tube), and then make sample container 1 The open end 12 of the mass spectrometer is located on the axis of the mass spectrometry sampling channel 2, so that the electric soldering iron continues to heat the bottom 11 of the sample container 1, and the mass analyzer is always in the collection state; Under the action of thermal energy, it can produce rapid eruption, so that ionization occurs.

[0050] Figure 4 For the mass spectrum obtained by Figure 4 The mass spectrum sh...

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Abstract

The invention discloses a quick ionizing method and device. The quick ionizing method is characterized in that a sample is ionized by quick eruption generated under the action of thermal energy. The quick ionizing device comprises a sample container, a mass spectrum sample introduction channel and a thermal energy generating device, wherein the open end of the sample container is positioned on the axis of the mass spectrum sample introduction channel; the thermal energy generating device is arranged at the bottom of the sample container. A technology for ionizing the sample by the quick eruption generated under the action of thermal energy is adopted, so that the method is easy to implement and operate, can meet the ionizing requirements of compounds of different molecular weights, and has low selectivity to a sample to be tested, a wide testable sample object range and high adaptability; moreover, a sample to be analyzed does not need pretreatment, so that the sampling operation is simplified, the analyzing time is greatly shortened, and quick in-situ analysis of a mass spectrum can be realized.

Description

technical field [0001] The invention relates to a fast ionization method and device, belonging to the technical field of mass spectrometry. Background technique [0002] Mass spectrometry (MS) is a powerful tool for the analysis of complex mixtures, providing information about the molecular weight and chemical structure of the analyte. In recent years, with the continuous innovation and improvement of ionization technology and mass analyzers, mass spectrometry has become one of the fastest-growing analytical technologies. At present, mass spectrometry technology is widely used in chemistry and chemical engineering, biology and life science, medicine, pharmacy, Applications in environmental protection and other fields are becoming more and more extensive. [0003] In recent years, the atmospheric pressure ionization method in mass spectrometry has begun to receive extensive attention and research interest. Atmospheric pressure ionization method has many advantages compared ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/10
CPCH01J49/10
Inventor 郭寅龙刘小潘王昊阳涂奇奇
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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