A kind of plant-type enteric-coated soft capsule

An enteric-coated soft capsule, plant-based technology, applied in the directions of capsule delivery, plant raw materials, plant/algae/fungus/moss components, etc., can solve the problems of easy cracking of the coating film, waste of resources, complicated processes, etc. The effect of coating process, environmental protection and process simplification

Active Publication Date: 2020-12-25
SIRIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional enteric-coated soft capsules are made from gelatin, glycerin and purified water, etc., and then coated with a layer of gastric acid-resistant enteric-coated material on the surface of the dried soft capsules through modern coating technology. This type of enteric-coated soft capsule is opaque and unattractive, and the coating material is easy to crack and fall off, which affects the function of the functional ingredients in the capsule in the intestinal tract
Common gastric acid-resistant enteric coating materials are mostly CAP or acrylic resin. Ethanol and acetone must be used as solvents during coating, and the solvents need to be evaporated during the molding process. On the one hand, the process is complicated, wastes resources, increases costs, and pollutes the air. On the other hand, there are still solvent residues in the capsule shell, and long-term use will affect the health of the human body
[0003] In summary, the current enteric-coated soft capsules have problems such as poor appearance transparency, easy cracking of the coating film after being pressed, affecting disintegration, drug release, complicated preparation process, waste of resources, solvent residues, and increased costs.

Method used

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  • A kind of plant-type enteric-coated soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of garlic oil plant-type enteric-coated soft capsules

[0029] 1. Prepare glue solution

[0030] a. Weigh 0.5 parts by mass of low-ester pectin and 10 parts by mass of glycerin, and mix them evenly to obtain the first liquid;

[0031] b. Take 0.001 parts by mass of calcium chloride, add it to 30 parts by mass of purified water, stir to make it completely dissolve, and obtain the second liquid;

[0032] c. Under stirring, add the first liquid into the second liquid, stir evenly, then add 2 parts by mass of carrageenan, keep heating and stirring at 95°C for 1 hour, and then remove the air bubbles in the glue by vacuuming to obtain the glue liquid.

[0033] 2. Preparation of Filling

[0034] Stir and mix 10 parts by mass of garlic oil, 89 parts by mass of soybean oil and 1 part by mass of natural vitamin E as a filling, and set aside.

[0035] 3. Compressed soft capsules

[0036] Install the soft capsule pill pressing equipment, transport the gl...

Embodiment 2

[0039] Example 2: Preparation of garlic oil plant-type enteric-coated soft capsules

[0040] 1. Prepare glue solution

[0041] a. Weigh 4 parts by mass of amide pectin and 20 parts by mass of glycerin, and mix them evenly to obtain the first liquid;

[0042] b. Weigh 0.03 parts by mass of calcium chloride, add it to 50 parts by mass of purified water, and stir to completely dissolve it to obtain the second liquid;

[0043] c. Add the first liquid into the second liquid under stirring, stir evenly, then add 40 parts by mass of gelatin, keep heating and stirring at 75°C for 2 hours, and then remove the air bubbles in the glue liquid by vacuuming to obtain the plant of the present invention The glue of type enteric-coated soft capsule.

[0044] 2. Preparation of Filling

[0045] Mix 10 parts by mass of garlic oil, 89 parts by mass of soybean oil and 1 part by mass of natural vitamin E as a filler and set aside.

[0046] 3. Compressed soft capsules

[0047] Install the soft c...

Embodiment 3

[0050]Example 3: Preparation of garlic oil plant-type enteric-coated soft capsules

[0051] 1. Prepare glue solution

[0052] a. Weigh 10 parts by mass of sodium alginate and 35 parts by mass of glycerin, and mix them evenly to obtain the first liquid;

[0053] b. Take 1 mass part of calcium chloride, add it to 70 mass parts of purified water, stir to make it completely dissolve, and obtain the second liquid;

[0054] c. Add the first liquid to the second liquid under stirring, stir evenly, then add 40 parts by mass of gelatin, keep heating and stirring at 60°C for 3 hours, and then remove the air bubbles in the glue liquid by vacuuming to obtain the plant of the present invention The glue of type enteric-coated soft capsule.

[0055] 2. Preparation of Filling

[0056] 10 parts by mass of garlic oil, 89 parts by mass of soybean oil and 1 part by mass of natural vitamin E are uniformly mixed as a filler and set aside.

[0057] 3. Compressed soft capsules

[0058] Install t...

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Abstract

The invention discloses a plant type enteric soft capsule. The capsule comprises dispensing and content, and is prepared by the steps of preparing dispensing, preparing filler, pressing soft capsules and drying. The shell of the plant type enteric soft capsule has good transparency, has a disintegration time in accordance with the specification of domestic and international pharmacopeias, namely having the characteristics that the shell is not disintegrated in a hydrochloric acid solution (artificial gastric juice) within two hours and quickly disintegrated in artificial intestinal juice within 15 minutes. Compared with enteric coated soft capsules, the plant type enteric soft capsule has the advantages that the coating process is reduced, the process is simplified, an organic solvent is not used, safe production and environmental protection are benefitted, efficiency can be improved, and cost can be reduced.

Description

technical field [0001] The invention relates to a plant-type enteric-coated soft capsule and a preparation method thereof, which can be applied to the fields of food, health products, medicines and the like. Background technique [0002] Enteric-coated soft capsules mean that the capsule shell does not break in artificial gastric juice, but can disintegrate in artificial intestinal juice to release the active ingredients in the capsule. Traditional enteric-coated soft capsules are made from gelatin, glycerin and purified water, etc., and then coated with a layer of gastric acid-resistant enteric-coated material on the surface of the dried soft capsules through modern coating technology. The appearance of this type of enteric-coated soft capsule is opaque and unattractive, and the coating material is easy to crack and fall off, which affects the function of the functional ingredients in the capsule in the intestinal tract. Common gastric acid-resistant enteric coating materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/04A61K47/36A61K47/26A61K47/10A61K31/355A61K35/60A61K36/48A61K36/534A61K36/8962
CPCA23V2002/00A61K9/4816A61K9/4825A61K31/355A61K35/60A61K36/48A61K36/534A61K36/8962A61K2300/00A23V2250/21A23V2250/212A23V2250/712A23V2300/38A23V2250/2042
Inventor 陈琼李绪发
Owner SIRIO PHARMA CO LTD
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