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A kind of preparation method of captopril microcapsule

A technology of capto and microcapsules, which is applied in the field of preparation of captopril microcapsules, can solve problems such as large side effects, achieve the effect of prolonging the action time, improving the bioavailability of drugs, and reducing the toxic and side effects of drugs

Active Publication Date: 2018-11-02
CHANGSHA BAISHUN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The elimination half-life of captopril in the blood is 2.2 to 5 hours. In order to maintain the trough concentration and still be effective, the dosage must be increased, and long-term medication may bring greater side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prescription for captopril microcapsules:

[0022] Captopril 10g

[0023] Gelatin 25g

[0024] Gum Arabic 18g

[0025] Glycerin 30g

[0026] Preparation: (1) Grind captopril finely, pass through an 80-mesh sieve, add the prescribed amount of glycerin, grind and evenly set aside;

[0027] (2) Dissolve gelatin and gum arabic in water, heat in a water bath at 45°C, slowly add to (1), stir and emulsify at 400r / min for 8min to form an emulsion, adjust the pH value to 3 with 2mol / L hydrochloric acid, Temperature control 45°C;

[0028] (3) Add 300ml of 0.09% sodium chloride solution to (2), adjust the pH value to 8.5 with 2mol / L sodium hydroxide after cooling to room temperature, add 37% formaldehyde solution to solidify the microcapsules, let stand, and filter with suction. Wash with water until formaldehyde-free, dry at 40°C to obtain microcapsules, pass through a 100-mesh sieve for preparation.

Embodiment 2

[0030] Prescription for captopril microcapsules:

[0031] Captopril 10g

[0032] Gelatin 30g

[0033] Sodium Alginate 12g

[0034] Glycerin 30g

[0035] Preparation: (1) Grind captopril finely, pass through an 80-mesh sieve, add the prescribed amount of glycerin, grind and evenly set aside;

[0036] (2) Dissolve the capsule material in water, heat in a water bath at 45°C, add (1) slowly, stir and emulsify at 500r / min for 6 minutes to make it into an emulsion, adjust the pH value to 3 with 2mol / L hydrochloric acid, and control the temperature 45°C;

[0037] (3) Add 400ml of 0.09% sodium chloride solution to (2), adjust the pH value to 8.5 with 2mol / L sodium hydroxide after cooling to room temperature, add 37% formaldehyde solution to solidify the microcapsules, let stand, and filter with suction. Wash with water until formaldehyde-free, dry at 40°C to obtain microcapsules, pass through a 100-mesh sieve for preparation.

Embodiment 3

[0039] Prescription for captopril microcapsules:

[0040] Captopril 10g

[0041] Gelatin 21g

[0042] Sodium Alginate 21g

[0043] Glycerin 30g

[0044] Preparation: (1) Grind captopril finely, pass through an 80-mesh sieve, add the prescribed amount of glycerin, grind and evenly set aside;

[0045] (2) Dissolve the capsule material in water, heat in a water bath at 45°C, add (1) slowly, stir and emulsify at 500r / min for 6 minutes to make it into an emulsion, adjust the pH value to 3 with 2mol / L hydrochloric acid, and control the temperature 45°C;

[0046] (3) Add 400ml of 0.09% sodium chloride solution to (2), adjust the pH value to 8.5 with 2mol / L sodium hydroxide after cooling to room temperature, add 37% formaldehyde solution to solidify the microcapsules, let stand, and filter with suction. Wash with water until formaldehyde-free, dry at 40°C to obtain microcapsules, pass through a 100-mesh sieve for preparation.

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Abstract

The invention provides a method for preparing a captopril microcapsule. The microcapsule is prepared from the following components in parts by weight: 5-15 parts of captopril, 30-40 parts of a wetting agent and 30-60 parts of a capsule material. The microcapsule is prepared from captopril, has low toxic and side effect in medication, has a function of prolonging the drug acting time and maintaining the plasma concentration, and can be used for improving the bioavailability of drugs.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of captopril microcapsules. Background technique [0002] Microcapsules are drug store-type microcapsules that use natural or synthetic polymer materials (collectively referred to as capsule materials) as the capsule wall shell to wrap solid or liquid drugs. Generally, those with a particle size between 1 and 250 μm are called microcapsules, those with a particle size between 0.1 and 1 μm are called submicrocapsules, and those with a particle size between 10 and 100 nm are called nanocapsules. The drug is made into microcapsules or microspheres, which can mask the bad smell and taste of the drug; it can also improve the stability of the drug; it will reduce the irritation of the drug to the stomach; solidify the liquid drug to facilitate its use; reduce the compatibility changes of compound drugs ; The most widely used is the formation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/401A61P9/12
CPCA61K9/0002A61K9/5036A61K9/5042A61K9/5057A61K31/401
Inventor 曾吉波
Owner CHANGSHA BAISHUN BIOTECH