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Method for quickly detecting extracting solution of Ganmaoling granules by utilizing near-infrared spectrometry and application of method

A technology of near-infrared spectroscopy and near-infrared spectroscopy, which is used in measuring devices, material analysis by optical means, instruments, etc., can solve the problems of inability to reflect the complexity of the composition of Ganmaoling granules, and the detection method is time-consuming and labor-intensive.

Active Publication Date: 2016-05-11
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, on the one hand, this detection method is time-consuming and laborious, difficult to be widely used in production practice, and cannot meet the needs of the modern development of traditional Chinese medicine preparations; The quality of the extraction process of the granules cannot reflect the complexity of the composition of Ganmaoling granules

Method used

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  • Method for quickly detecting extracting solution of Ganmaoling granules by utilizing near-infrared spectrometry and application of method
  • Method for quickly detecting extracting solution of Ganmaoling granules by utilizing near-infrared spectrometry and application of method
  • Method for quickly detecting extracting solution of Ganmaoling granules by utilizing near-infrared spectrometry and application of method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088]The composition of raw materials of Ganmaoling granules in this example is: 491g of trigeminal bitter, 322g of calendula silver plate, 245g of wild chrysanthemum, 735g of plum, 0.40g of caffeine, 20g of acetaminophen, and 0.40g of chlorpheniramine maleate , peppermint oil 0.20mL;

[0089] The preparation method of the extract of Ganmaoling Granules comprises the following steps: take selected weights of Sanchaku, Marigold Silverpan, Wild Chrysanthemum and Gangmei, add water and reflux for extraction twice, and use Sanchaku, Calendula Silverpan, Wild Chrysanthemum Based on the total weight of chrysanthemums and plums, 5 times the weight of water is added each time for extraction for 2 hours, and the extracts are combined and concentrated to obtain the product.

Embodiment 2

[0091] In this embodiment, the method for rapidly detecting the extract of Ganmaoling granules by using near-infrared spectroscopy includes the following steps for determining the content of fenugreek:

[0092] (1) Select the extract of Ganmaoling granules whose content is known, and use high-performance liquid chromatography to measure the content of Ganmaoling. Centrifuge for 10 minutes under the same conditions, take the supernatant, as the test solution; accurately weigh 2 mg of the reference substance of saponin, place it in a 20mL measuring bottle, add methanol to make a solution containing 0.1mg per mL, shake well, and use it as the reference substance solution; chromatographic conditions: use 0.5% formic acid as mobile phase A and acetonitrile as mobile phase B to carry out gradient elution according to the following procedure: 0-7min, A: B is 87%: 13%; 7-27min, A: B is 87%: 13%→70%: 30%; 27-35min, A: B is 70%: 30%→60%: 40%; 35-50min, A: B is 60%: 40%; flow rate 1.0mL / ...

Embodiment 3

[0108] In this embodiment, the method for rapidly detecting the extract of Ganmaoling Granules by using near-infrared spectroscopy includes the following steps for determining the content of chlorogenic acid:

[0109] (1) Select the extract of Ganmaoling granules with known chlorogenic acid content, and measure the chlorogenic acid content by high performance liquid chromatography. Centrifuge for 8 to 12 minutes under the same conditions, take the supernatant as the test solution; accurately weigh 2 mg of chlorogenic acid reference substance and place it in a 20 mL measuring bottle, add methanol to make a solution containing 0.1 mg per mL, shake well, and use as Reference substance solution; chromatographic conditions: use 0.5% formic acid as mobile phase A and acetonitrile as mobile phase B to carry out gradient elution according to the following procedure: 0-7min, A: B is 87%: 13%; 7-27min, A: B is 87%: 13%→70%: 30%; 27-35min, A: B is 70%: 30%→60%: 40%; 35-50min, A: B is 60%...

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Abstract

The invention relates to a method for quickly detecting an extracting solution of Ganmaoling granules by utilizing near-infrared spectrometry. The method comprises the steps of linarin content determination and / or chlorogenic acid content determination and / or solid content determination. According to the method provided by the invention, linarin content, chlorogenic acid content and solid content near-infrared online analytical methods are established in an extraction process of the Ganmaoling granules, and are applied to online detection, so that automatic detection and real-time prediction of various index contents of the extraction process of the Ganmaoling granules are realized; an established model is high in prediction precision, and high in accuracy, and meets the requirement of quantitative analysis in actual production; by the method, quick and efficient real-time monitoring and control can be carried out on quality of the extraction process, so that the safety, stability and effectiveness of the final product quality are favorably ensured.

Description

technical field [0001] The invention belongs to the technical field of medicinal material detection, and in particular relates to a method and application for rapidly detecting the extract of Ganmaoling granules by using near-infrared spectroscopy. Background technique [0002] Ganmaoling Granules are recorded in the eighth volume of Chinese medicine prescription preparations in the drug standard of the People's Republic of China. Peppermint oil is composed of eight raw materials, has antipyretic and analgesic effects, and is used for headache, fever, nasal congestion, sore throat, etc. caused by colds. In the prescription, the four traditional Chinese medicines all have the effect of clearing away heat and detoxifying, and are widely used in the treatment and prevention of colds and other febrile diseases. etc., have obvious antibacterial and antiviral effects; calendula silver plate relieves heat, detoxifies, and dissipates blood stasis, and is mainly used for influenza, ...

Claims

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Application Information

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IPC IPC(8): G01N21/359G01N21/3577
CPCG01N21/3577G01N21/359
Inventor 张跃飞王龙虎林丽娜邓海欣陈周全刘雪松陈国权刘志刚马舒冰马鹏岗
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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