Pharmaceutical composition for treating psoriasis and preparation method thereof

A composition and technology for psoriasis, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problems of recurrent, easy recurrence or aggravation of psoriasis, and achieve the effects of reducing dandruff shedding, enhancing curative effect, and formulating rational and scientific prescriptions.

Inactive Publication Date: 2016-05-25
广西复鑫益生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Psoriasis, commonly known as "psoriasis", is an inflammatory and recurrent skin disease characterized by erythema, papules, and silvery white scales. The exact cause of the recurrence is not yet clear, and there is no fundamental therapy to control its recurrence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1 liniment

[0059] Weigh 5kg of white back leaf, 10kg of water group flower, 5kg of white fresh skin, and 5kg of comfrey. Heated and refluxed with ethanol for 2 extractions, each ethanol concentration was 80% and 40% respectively, the amount of ethanol each time was 10 times and 8 times the total amount of medicinal materials, and the extraction time was 3 hours and 1 hour respectively, and the extracts were combined. Filtrate, recover ethanol from the filtrate, add 0.1% sodium benzoate and 0.05% methylparaben, mix evenly, and pack separately to obtain the liniment of the present invention.

Embodiment 2

[0060] Embodiment 2 Ointment

[0061] Weigh 15kg of white back leaves, 20kg of water ball flowers, 15kg of white fresh skin, and 15kg of comfrey. Add water to extract 3 times, the amount of water added for the three times is 12 times, 8 times, 6 times of the total weight of the medicinal materials, the extraction time is 3 hours, 2 hours, 1 hour respectively, the extracts are combined, filtered, and the filtrate is concentrated to 80 ° C. Clear paste with a density of 1.20, set aside.

[0062] Weigh 15g of stearic acid, 100g of vaseline, 80g of lanolin, 35g of glyceryl stearate, and 80g of cetyl alcohol, heat to 85°C, stir well, and use it as the oil phase for later use; Add 2g of ester, 20g of sodium lauryl sulfate, and 25g of laurocaprazine, add the above-mentioned thick cream and volatile oil, adjust with water to make the two phases of oil and water total 1000g, use it as the water phase, heat to 90°C, and wait until it is completely dissolved. Stir to 85°C; slowly add t...

Embodiment 3

[0063] Embodiment 3 ointment

[0064] Composition 1: 5kg of white back leaf, 10kg of water group flower, 5kg of white fresh skin, 5kg of comfrey;

[0065] Composition 2: 5 kg of acetic acid, 3 kg of indirubin, and 50 kg of petrolatum.

[0066] The pharmaceutical composition for the treatment of psoriasis, its ointment is prepared by the following method:

[0067] (1) Extract all the drugs in Composition 1 with 80% ethanol solvent for 2 times, the amount of solvent added each time is equivalent to 10 times and 8 times of the total weight of the drug, and the extraction time is 2 hours each time, combine the extracts, filter After the filtrate is concentrated to a clear paste with a relative density of 1.15 at 70°C;

[0068] (2) The indirubin in composition 2 is crushed and passed through an 80-mesh sieve, and mixed evenly with the clear paste obtained in step (1) to obtain a mixture;

[0069] (3) Heat and melt the vaseline in composition 2, cool to 40°C, add acetic acid in c...

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating psoriasis and a preparation method thereof. The pharmaceutical composition is prepared from mallotus apelta, adina pilulifera, cortex dictamni, radix arnebiae seu lithospermi, acetic acid, vaseline and indirubin. The pharmaceutical composition has the functions of clearing heat and expelling dampness and cooling blood and eliminating toxins, and has excellent treatment effect on blood-heat and blood-dryness type psoriasis.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for treating psoriasis and a preparation method thereof. Background technique [0002] Psoriasis, commonly known as "psoriasis", is an inflammatory and recurrent skin disease characterized by erythema, papules, and silvery white scales. The exact cause of the disease is not yet known, and there is no fundamental therapy that can control its recurrence. Therefore, the treatment plan should advocate the principle of "green and non-toxic, reducing recurrence". [0003] Traditional Chinese medicine believes that the etiology and pathogenesis of psoriasis are mostly hot and dry skin of the body, and blood heat, blood dryness, and yin consumption will cause the disease for a long time, and the pathogenesis of blood heat runs through the whole process of psoriasis, and the treatment often uses heat-clearing and detoxification , Cooling blood and promoting blood ci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61P17/06
CPCA61K36/47A61K9/0014A61K9/06A61K36/30A61K36/74A61K36/75A61K47/06A61K47/10A61K47/44A61K2236/331A61K2236/333A61K2236/39A61K2236/51
Inventor 何东良
Owner 广西复鑫益生物科技有限公司
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