Traditional Chinese medicine for treating diabetic ketoacidosis and preparing method thereof

A technology for diabetic ketoacidosis and acidosis, which is applied in the field of traditional Chinese medicine for treating diabetic ketoacidosis and its preparation, can solve the problems of loss; acidosis, blood pressure drop, improper treatment, etc., and achieves simple preparation process, safe and convenient use, good treatment effect

Inactive Publication Date: 2016-05-25
蔡玉萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Improper treatment: Insufficient or interrupted insulin dose is a common cause of DKA in type 1 diabetes, and the interruption and insufficient dose of hypoglycemic drugs can also induce DKA
3. Electrolyte balance disorder, osmotic diuresis, and a large amount of sodium, potassium, chloride, phosphate and other ions are lost at the same time; acidosis causes potassium ions to be released from the cells to the outside of the cells, and the renal tubules compete with hydrogen ions to make the potassium loss more serious Obviously, but because the water loss is greater than the salt loss, and the blood is concentrated, the blood potassium concentration may be normal or high before treatment, but as the treatment progresses, after blood volume supplementation, insulin injection, and acidosis correction, severe hypokalemia may occur , risk of cardiac arrhythmias and cardiac arrest
Usually direct effects outweigh indirect effects, but indirect effects are slower and longer lasting
5. Peripheral circulatory failure and renal dysfunction. Severe dehydration, decreased blood volume, and micro-drunk ring disorder caused by acidosis. If not corrected in time, it will eventually lead to hypovolemic shock and blood pressure drop.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] When the dosage form of the Chinese medicine is a powder, its preparation method may further comprise the steps:

[0048] The first step is to mix the various raw materials of the traditional Chinese medicine in proportion, add ethanol with an alcohol concentration of 85% to 95% relative to the mass of the mixture, heat and reflux for 2 to 4 hours, extract, and filter to obtain the first extraction liquid; the medicinal dregs obtained by filtering are then added with ethanol having an alcohol concentration of 2 to 4 times the mass of the medicinal dregs, which is 85% to 95% ethanol, heated and refluxed for 1 to 3 hours, extracted, and filtered to obtain a second extract; The first extract and the second extract are combined, concentrated under reduced pressure to remove the ethanol solvent, and dried to obtain a dry paste;

[0049] In the second step, the dry paste obtained in the first step is placed in an ultrafine pulverizer for 1 to 2 hours, pulverized, and sieved t...

Embodiment 1

[0058] Embodiment 1: the powder prepared by the present invention

[0059] Take 160g of bald sore flower, 290g of poisonous weed, 210g of red head grass, 350g of yellow-footed chicken, 260g of pheasant feast, 150g of wheat bottle grass, 290g of wood bamboo, 210g of japonica, 180g of cicada grass, 360g of jade cypress, 150g of water gardenia root, and Ganmu Tong 270g, Qingtiankui 250g, Southern Suanzao 310g, Baisu stem 190g, Fushen 70g, Pinwheel rattan 310g, Summer solstice grass 150g, Shifengdan 260g, Starling wood 190g and Tiehua powder 120g.

[0060] Its preparation method comprises the following steps:

[0061] The first step is to mix the raw materials of the traditional Chinese medicine in proportion, add ethanol with an alcohol concentration of 95% that is 6 times the mass of the mixture, heat and reflux for 4 hours, extract, and filter to obtain the first extract; filter the obtained dregs Then add ethanol with an alcohol concentration of 90% relative to the quality of...

Embodiment 2

[0064] Embodiment 2: the capsule prepared by the present invention

[0065] Take 190g of bald sore flower, 260g of poisonous weed, 250g of red head grass, 310g of yellow-footed chicken, 280g of pheasant feast, 120g of wheat bottle grass, 260g of wood bamboo, 250g of japonica, 160g of chrysanthemum, 390g of jade cypress, 120g of water gardenia, 120g of sweet wood Tong 280g, Qingtiankui 210g, South Suanzao 350g, Baisu stem 160g, Fushen 90g, windmill rattan 330g, summer solstice grass 120g, Shifengdan 280g, starling wood 170g and Tiehua powder 130g.

[0066] Its preparation method comprises the following steps:

[0067] In the first step, mix bald sore flower, poisonous weed, red-headed grass, yellow-footed chicken, pheasant's feast, wheat bottle grass, wood bamboo and scorpion according to the stated ratio, add 5 times the water to extract the volatile oil relative to the mixture, and obtain The volatile oil is clathrated with β-cyclodextrin, the ratio of volatile oil to β-cycl...

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PUM

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Abstract

The invention provides traditional Chinese medicine for treating diabetic ketoacidosis and a preparing method thereof. The traditional Chinese medicine is prepared from herba dicranostigma leptopodum, mamyflower gueldenstaedtid herbs, herba blumea lacera, rhizome of perny false fairybells, herba dewberryleaf cinquefoil, herba silene conoidea, oblongleaf Garcinia fruit and bark, castanopsis sclerophylla seeds, dindygulen peperomia herbs, herba lycopodium obscurum, large-flowered gardenia roots, leaves of clematis filamentosa dunn, leaves of ford nervilia, axillary choerospondias fruit, common perilla stems, roots of mor angelica, bengal hiptage stems, herba whiteflower lagopsis, tall rattlesnake plantain herbs, wood of largeleaf dogwood and rust powder made of iron and acetic acid. The traditional Chinese medicine has the advantages that the traditional Chinese medicine is matched with a Western medicine conventional method to treat diabetic ketoacidosis, is safe and convenient to use, good in treatment effect, free of side effects and untoward effects and simple in preparation technology and takes effect fast.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine engineering, in particular to a traditional Chinese medicine for treating diabetic ketoacidosis and a preparation method thereof. Background technique [0002] Diabetic ketoacidosis (diabeticketoacidosis, DKA) is a serious acute complication of diabetes. When the metabolic disorder develops to the accelerated decomposition of fat and the accumulation of serum ketones exceeds the normal level of 2mmol / L (0.3-2.0mg / dl), it is called ketosis, and its clinical manifestation is ketosis. When metabolic acidosis occurs due to the accumulation of ketoacids, it is called ketoacidosis. If the condition is severe and coma occurs, it is called diabetic coma. This group of symptoms is common in insulin-dependent (type Ⅰ) or non-insulin-dependent (type Ⅱ) with stress. Fatigue and weakness at the beginning of the disease, weakness of limbs, extreme thirst, polydipsia, polyuria, increased u...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P3/10A61P3/12A61K33/26
CPCA61K36/66A61K9/146A61K9/4858A61K33/26A61K36/11A61K36/185A61K36/22A61K36/232A61K36/28A61K36/36A61K36/40A61K36/53A61K36/535A61K36/67A61K36/716A61K36/73A61K36/744A61K36/86A61K36/896A61K36/898A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 蔡玉萍
Owner 蔡玉萍
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