Molecular imprinting-Raman combination detection method of sulfadimidine in milk

Abstract

The invention discloses a molecular imprinting-Raman combination detection method of sulfadimidine in milk. The method can realize rapid low-cost detection of excess sulfadimidine in milk. A hydrogel prepared through a molecular imprinting technology is used to complete adsorption and enrichment of sulfadimidine in a detected sample in 5min, and a portable Raman spectrometer is used to collect spectrum information, so the whole process is rapid and convenient; and the hydrogel can be repeatedly used, so the detection cost is reduced, environmental protection is realized, and onsite high-flux detection requirements are met.

Description

technical field [0001] The invention relates to a detection method, in particular to a molecular imprint-Raman combined detection method of sulfamethazine in milk. Background technique [0002] As a commonly used sulfonamide antibacterial agent, sulfamethazine is widely used to prevent and treat bacterial infectious diseases in dairy cattle. Because of its long action time and metabolism time in animals, it is easy to remain in animal tissues and then enter animal secretions (such as milk). Long-term consumption of dairy products with high residues of sulfonamides will have serious consequences on the health of the human body, especially infants and young children. At present, the detection methods of sulfa drug residues in milk include high performance liquid chromatography (HPLC), gas chromatography (GC), gas-mass spectrometry (GC / MS), liquid-mass spectrometry (LC / MS), etc. . Although the existing methods have the advantages of high sensitivity and low detection limit, ...

AI Technical Summary

Problems solved by technology

Although the existing method has the advantages of high sensitivity and low detection limit, it is difficult to meet the current situation of frequent food safety problems due to expensive instruments, long time consumption, and high detection cost.