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High-deficiency arsenomolybdate sandwich type supramolecular compound and synthesis method and application thereof

A supramolecular compound, sandwich-type technology, applied in iron organic compounds, iron group organic compounds without C-metal bonds, organic chemistry, etc., can solve the problem that the research on the anti-tumor activity of sandwich-type molybdate is still blank

Inactive Publication Date: 2016-06-15
KUNMING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, the research on the antitumor activity of sandwich molybdate (especially high vacancy molybdate) is still blank.

Method used

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  • High-deficiency arsenomolybdate sandwich type supramolecular compound and synthesis method and application thereof
  • High-deficiency arsenomolybdate sandwich type supramolecular compound and synthesis method and application thereof
  • High-deficiency arsenomolybdate sandwich type supramolecular compound and synthesis method and application thereof

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preparation example Construction

[0020] The preparation method of the high-vacancy arsenomolybdic acid sandwich supramolecular compound of the present invention is characterized in that it comprises the following steps:

[0021] A. Add 0.29g (NH 4 ) 12 [Fe 2 (AsMo 7 o 27 ) 2 ]·12H 2 O was dissolved in 20ml of distilled water, stirred for 10min, and 0.13ml of 0.2mol / L hydrochloric acid was added dropwise to obtain solution a;

[0022] B. Then reflux solution a for 2~4h, cool to room temperature and filter, seal the filtrate with a thin film with small holes and slowly volatilize for 7~10 days to obtain massive crystals, rinse with methanol, and dry naturally in the air to obtain the target object.

[0023] The application of the high-vacancy arsenomolybdic acid sandwich supramolecular compound in the present invention is the application of the high-vacancy arsenomolybdic acid sandwich supramolecular compound in the preparation of anticancer drugs.

[0024] The application of the high-vacancy arsenomolyb...

Embodiment 1

[0027] Take 0.29g (NH 4 ) 12 [Fe 2 (AsMo 7 o 27 ) 2 ]·12H 2 O was dissolved in 20mL distilled water, stirred for 10 minutes, then 0.13ml, 0.2mol / L HCl was added dropwise, and then 0.1mol / L ethylenediamine was added to adjust the pH value of the solution to 7, and the resulting solution was refluxed for 3 hours, and cooled to room temperature Filter and seal the filtrate with a membrane with small holes for slow evaporation. Blocky crystals were obtained after one week. Rinse with methanol and air dry. Yield 35%, theoretical value of elemental analysis: C, 1.48; H, 1.67; Mo, 41.41; Fe, 3.44; experimental value: C, 1.43; H, 1.52Mo, 41.12; The single crystal X-ray diffraction data show that the high-vacancy arsenomolybdate sandwich supramolecular compound prepared in this example crystallizes in the monoclinic system P-1 space group. Its asymmetric unit contains a [Fe 2 (AsMo 7 o 27 ) 2 ] 12- Anion Two ethylenediamine cations and six water molecules. where [Fe 2 (...

Embodiment 2

[0029] The difference between this embodiment and embodiment 1 is that 0.35g (NH 4 ) 12 [Fe 2 (AsMo 7 o 27 ) 2 ]·12H 2 O was dissolved in 20 mL of distilled water and stirred for 10 minutes. Other steps and parameters were the same as in Example 1.

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Abstract

The invention discloses a high-deficiency arsenomolybdate sandwich type supramolecular compound and a synthesis method and application thereof. The high-deficiency arsenomolybdate sandwich type supramolecular compound consists of methylimidazole counter cations and methylimidazole sandwich type heteropoly acid fragments, is a single crystal, belongs to a triclinic crystal system, and is P-1 in space group; cell parameters are a=11.9794(13) angstrom, b=17.674(2) angstrom, c=19.019(2) angstrom, alpha=63.031(2) degrees, beta=87.797(2) degrees, and gamma=86.113(2) degrees; the molecular formula is [Fe2(AsMo7O27)2](H2en)2(NH4)8.6H2O. The preparation method comprises the following steps: dissolving 0.29g of (NH4)12[Fe2(AsMo7O27)2].12H2O into 20ml of distilled water, stirring for 10 minutes, and dropwise adding 0.13ml of 0.2mol / L hydrochloric acid to obtain a solution a; performing back flowing for 2-4 hours, filtering, volatilizing slowly for 7-10 days to obtain a blocked crystal, flushing and drying to obtain a target. The high-deficiency arsenomolybdate sandwich type supramolecular compound is applied to preparation of anti-cancer drugs. In a process of synthesizing novel supermolecules, the stability and biocompatibility of the single crystal are further improved under the actions of multiple hydrogen bonds of ethidene diamine cations. A single-crystal structure provides novel data for a crystal database at the same time, and biological activity indicates that the introduction of the ethidene diamine serving as an organic component can further improve the anti-tumor effect of a precursor.

Description

technical field [0001] The invention belongs to the technical field of chemical compounds, in particular to a high-vacancy arsenomolybdic acid sandwich type supramolecular compound and its synthesis method and application. Background technique [0002] Malignant tumors are currently one of the most serious diseases that endanger human health, and their mortality rate is second only to cardiovascular diseases. In the past 50 years, through the unremitting efforts of scientists from all over the world, great progress has been made in the basic and clinical aspects of tumor epidemiology, clinical diagnosis and treatment of pathogenesis, but there are still many difficult problems to be solved. At present, the treatment of tumors is mainly surgical treatment, radiotherapy and chemotherapy. With the research on the subcellular level and molecular level of the mechanism of drug action, the discovery of new anticancer drugs, the change of combined drugs and drug routes, chemotherap...

Claims

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Application Information

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IPC IPC(8): C07F19/00A61P35/00
CPCC07F15/025
Inventor 吴琼句红萍陶剑
Owner KUNMING UNIV
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