Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ointment for treating dermatitis and eczema and preparation method thereof

A technology for eczema and ointment, which is applied in the direction of anti-inflammatory agents, medical preparations containing active ingredients, skin diseases, etc., can solve problems such as pigmentation, many side effects, and skin thinning, so as to improve compliance, reduce side effects, reduce skin irritating effects

Active Publication Date: 2016-06-22
江西省皮肤病专科医院
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The hydrocortisone butyrate ointment or cream circulating on the market are mostly unilateral preparations, wherein the content of hydrocortisone butyrate is generally 0.1%, although effective, the disadvantage of using steroid corticosteroids alone is that the side effects are relatively low. Many, such as skin thinning, muscle atrophy, acne, hirsutism, pigmentation, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ointment for treating dermatitis and eczema and preparation method thereof
  • Ointment for treating dermatitis and eczema and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] An ointment for dermatitis and eczema, its composition is calculated by weight percentage, hydrocortisone butyrate 0.05%, menthol 2%, borneol 3.5%, laurocaprone 2%, glyceryl monostearate 7% , 8% cetyl alcohol, 10% white petrolatum, 3% liquid paraffin, 8% glycerin, Ping Pinga O 6%, 800.5% Tween, 8% propylene glycol, 0.5% citric acid, 0.02% sodium citrate, hydroxyl 0.05% phenethyl ester, appropriate amount of purified water.

[0024] Accurately weighed according to the above ratio, the preparation method of the cream is as follows: (1) Oil phase preparation: Mix glyceryl monostearate, cetyl alcohol, white petrolatum, and liquid paraffin, heat and melt to form a solution, and keep the temperature at 85°C ; (2) Preparation of water phase: Mix glycerin, Pingpingjia O, Tween 80, propylene glycol, citric acid, sodium citrate, ethylparaben, and purified water, then heat and keep the temperature at 80°C; (3) Convergence: slowly add the oil phase prepared in step (1) into the wa...

Embodiment 2

[0026] An ointment for dermatitis and eczema, its composition is by weight percentage, hydrocortisone butyrate 0.06%, camphor 2.5%, borneol 2.5%, laurocaprone 2.5%, glyceryl monostearate 8%, Cetyl Alcohol 8%, White Petrolatum 12%, Liquid Paraffin 7%, Glycerin 10%, Pinga O5%, Tween 801.5%, Propylene Glycol 10%, Citric Acid 0.5%, Sodium Citrate 0.02%, Ethylparaben 0.08% ester, appropriate amount of purified water.

[0027] Accurately weighed according to the above ratio, the preparation method of the cream is as follows: (1) Oil phase preparation: Mix glyceryl monostearate, cetyl alcohol, white petrolatum, and liquid paraffin, heat and melt to form a solution, and keep the temperature at 82°C ; (2) Preparation of water phase: Mix glycerin, Pingpingjia O, Tween 80, propylene glycol, citric acid, sodium citrate, ethylparaben, and purified water, then heat and keep the temperature at 80°C; (3) Convergence: slowly add the oil phase prepared in step (1) into the water phase prepared...

Embodiment 3

[0029] An ointment for dermatitis and eczema, its composition is calculated by weight percentage, hydrocortisone butyrate 0.08%, menthol 2.5%, camphor 2.5%, laurocaprone 3%, glyceryl monostearate 8% , 10% cetyl alcohol, 10% white petrolatum, 8% liquid paraffin, 10% glycerin, 8% Ping Pinga O, 803% Tween, 8% propylene glycol, 0.45% citric acid, 0.03% sodium citrate, hydroxybenzene 0.1% ethyl ester, appropriate amount of purified water.

[0030] Accurately weighed according to the above ratio, the preparation method of the cream is as follows: (1) Oil phase preparation: Mix glyceryl monostearate, cetyl alcohol, white petrolatum, and liquid paraffin, heat and melt to form a solution, and keep the temperature at 80°C ; (2) Preparation of water phase: Mix glycerin, Pingpingjia O, Tween 80, propylene glycol, citric acid, sodium citrate, ethylparaben, and purified water, then heat and keep the temperature at 80°C; (3) Convergence: slowly add the oil phase prepared in step (1) into th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicine composition for treating dermatitis, eczema and other skin diseases, in particular to an ointment with hydrocortisone butyrate as an active ingredient. The ointment for treating the dermatitis and eczema contains the hydrocortisone butyrate serving as the active ingredient and further contains any component of menthol, camphor and borneol serving as active ingredients and the balance ointment matrix. Compared with the prior art, the ointment has the following advantages that the side effects of the hydrocortisone butyrate are reduced, skin irritation is relieved, the itching, pain and swell relieving effect is remarkably improved, and the medication compliance of patients is obviously improved.

Description

technical field [0001] The invention relates to a medicine combination for treating skin diseases such as dermatitis and eczema, in particular to an ointment with hydrocortisone butyrate and the like as active components. Background technique [0002] Hydrocortisone butyrate is a medium-effect steroidal glucocorticoid, which can inhibit local vasodilation, reduce capillary permeability, inhibit the inflammatory response caused by lymphokines, and inhibit skin delayed allergic reactions. Anti-inflammatory, anti-allergic, immunosuppressive and other effects, and has a significant anti-inflammatory effect on skin diseases caused by non-infection. External application is mainly used for skin diseases such as allergic dermatitis, seborrheic dermatitis, eczema, and lichen simplex chronicus. [0003] The hydrocortisone butyrate ointment or cream circulating on the market are mostly unilateral preparations, wherein the content of hydrocortisone butyrate is generally 0.1%, although ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/573A61K31/045A61K31/125A61K31/55A61K9/06A61K47/06A61P17/00A61P17/04A61P17/08A61P29/00A61P37/08A61P37/06
CPCA61K47/06A61K9/0014A61K9/06A61K31/045A61K31/125A61K31/55A61K31/573A61K2300/00
Inventor 罗美兰耿承芳熊兴龙王小兵
Owner 江西省皮肤病专科医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com