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A kind of preparation method of Anweiyang Dispersible Tablet

A technology for Anweiyang dispersible tablets, which is applied in the field of preparation of Anweiyang dispersible tablets, can solve problems such as poor dispersion uniformity, achieve the effects of increasing water absorption, protecting gastric mucosa, and increasing solubility

Active Publication Date: 2018-08-24
惠州市九惠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because traditional Chinese medicine dispersible tablets generally have poor dispersion uniformity, there are still few dispersible tablets in general Chinese medicine preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A preparation method of Anweiyang Dispersible Tablets, comprising the following steps

[0018] S1. In parts by weight, add 1 part of Anweike and 2 parts of β-cyclodextrin to 5 parts of 1% sodium bicarbonate solution respectively, use a colloid mill to grind and dry to obtain an inclusion compound;

[0019] S2. According to parts by weight, 1 part of clathrate, 0.03 part of PPVP, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, and 0.1 part of calcium hydrogen phosphate are added to 5% povidone K30 solution for granulation, Uncoated Anweiyang Dispersible Tablets;

[0020] S3. HPMC, cross-linked sodium carboxymethyl starch, acrylic resin, glycerin, magnesium stearate, white pigment and cross-linked povidone are mixed to form a coating solution, and the uncoated Anweiyang dispersible tablets obtained in S2 are mixed. Carry out coating, that is to say.

Embodiment 2

[0022] A preparation method of Anweiyang Dispersible Tablets, comprising the following steps

[0023] S1. According to parts by weight, add 1 part of Anweike and 1 part of β-cyclodextrin to 4 parts of 1% sodium bicarbonate solution respectively, use a colloid mill to grind, dry, and obtain an inclusion compound;

[0024] S2. According to parts by weight, 1 part of clathrate, 0.03 part of PPVP, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, and 0.1 part of calcium hydrogen phosphate are added to 5% povidone K30 solution for granulation, Uncoated Anweiyang Dispersible Tablets;

[0025] S3. HPMC, cross-linked sodium carboxymethyl starch, acrylic resin, glycerin, magnesium stearate, white pigment and cross-linked povidone are mixed to form a coating solution, and the uncoated Anweiyang dispersible tablets obtained in S2 are mixed. Carry out coating, that is to say.

Embodiment 3

[0027] A preparation method of Anweiyang Dispersible Tablets, comprising the following steps

[0028] S1. In parts by weight, add 1 part of Anweike and 3 parts of β-cyclodextrin to 6 parts of 1% sodium bicarbonate solution respectively, use a colloid mill for grinding, and dry to obtain an inclusion compound;

[0029] S2. According to parts by weight, 1 part of clathrate, 0.03 part of PPVP, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, and 0.1 part of calcium hydrogen phosphate are added to 5% povidone K30 solution for granulation, Uncoated Anweiyang Dispersible Tablets;

[0030] S3. HPMC, cross-linked sodium carboxymethyl starch, acrylic resin, glycerin, magnesium stearate, white pigment and cross-linked povidone are mixed to form a coating solution, and the uncoated Anweiyang dispersible tablets obtained in S2 are mixed. Carry out coating, that is to say.

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PUM

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Abstract

The invention discloses a preparation method of Anweiyang dispersible tablets.The preparation method includes following steps: S1, adding Anweiyang and beta-cyclodextrin into a 1% sodium hydrogen carbonate solution respectively, utilizing a colloid mill for milling, and drying to obtain an inclusion compound; S2, granulating the inclusion compound, PPVP, microcrystalline cellulose, stevioside, calcium hydrogen phosphate and a 5% povidone K30 solution to obtain uncoated Anweiyang dispersible tablets; S3, mixing HPMC (hydroxyl propyl methyl cellulose), cross-linked sodium carboxymethyl starch, acrylic resin, glycerin, magnesium stearate, white pigment and cross-linked povidone to form coating liquid, and coating the uncoated Anweiyang dispersible tablets obtained in the S2 to obtain the Anweiyang dispersible tablets.The Anweiyang dispersible tablets obtained through the preparation method are suitable for being used as dispersible tablets and have the advantages of high dissolution speed and quick action.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine dispersible tablets, in particular to a preparation method of Anweiyang dispersible tablets. Background technique [0002] Dispersible tablet refers to a tablet that disintegrates rapidly and disperses uniformly in water. Dispersible tablets of traditional Chinese medicine are made of Chinese medicine extracts, traditional Chinese medicine powder or refined intermediates as raw materials, plus suitable auxiliary materials, and can quickly disintegrate and evenly disperse tablets in water. [0003] Anweiyang Capsules, tonify the middle and replenish qi, detoxify and promote muscle growth. Indications for gastric and duodenal ulcers. It has a good curative effect on patients with deficiency cold type and qi stagnation type. And can be used for maintenance treatment after ulcer healing. Anweiyang is made into dispersible tablets, which can increase its bioavailability, and release it q...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K47/69A61K47/32A61K36/484A61P1/04
CPCA61K9/0056A61K9/2027A61K9/2866A61K36/484A61K47/32
Inventor 黄德浩黄辉球刘强
Owner 惠州市九惠药业有限公司
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