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Method for extracting astragaloside by microorganisms

The technology of astragaloside IV and microorganisms is applied in the field of extracting astragaloside IV by microorganisms, which can solve the problems of high ethanol price, complicated extraction process, high toxicity and the like, and achieves the effects of low extraction cost, simple process and enhanced dissolution.

Inactive Publication Date: 2016-07-13
岳军堂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, methanol solvent is not only flammable and explosive, has a low boiling point, but also has high toxicity and high safety production requirements; ethanol is also flammable and explosive, and its extraction process is relatively complicated, requiring a large investment, and the price of ethanol is relatively high. substance has a bad smell
This limits the development and application of astragaloside IV to a great extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, the method utilizing microorganism to extract astragaloside IV is as follows:

[0018] (1) Potato starch fermentation culture: mix potato starch and water at a ratio of 1:6, and then add 100:0.20 compound enzyme and alcoholic yeast to the mixed species. The amount of compound enzyme added is: glucoamylase cellulase 10U / g, pectinase 10U / g, the temperature is controlled at 26-32°C, cultured for 5 days to form mash. (2) Processing of Astragalus raw material: crush the stalks of Astragalus into small particles with a particle size of 20 mesh. (3), astragalus powder added to the mash: add the pulverized astragalus powder to the mash, stir and mix and cultivate for 4 days; wherein the amount of astragalus powder added is 1:4 according to the weight ratio of potatoes and astragalus powder (4), solid-liquid separation: the Astragalus root powder and the mash culture are subjected to solid-liquid separation by a separation method. (5) Concentrate and dry the liqu...

Embodiment 2

[0019] Implementation example 2 utilizes the method for extracting astragaloside IV by microorganisms to be specific as follows:

[0020] (1) Potato starch fermentation culture: mix potato starch and water at a ratio of 1:6, and then add 100:0.25 compound enzyme and alcoholic yeast to the mixed species. The amount of compound enzyme added is: glucoamylase cellulase 10U / g, acid protease 10U / g, the temperature is controlled at 26-32°C, cultured for 6 days to form mash. (2) Processing of Astragalus raw material: crush the stalks of Astragalus into small particles with a particle size of 22 mesh. (3), astragalus powder added to the mash: add the pulverized astragalus powder to the mash, stir and mix and cultivate for 5 days; wherein the amount of astragalus powder added is 1:3 according to the weight ratio of potatoes and astragalus powder (4), solid-liquid separation: the Astragalus root powder and the mash culture are subjected to solid-liquid separation by a separation method....

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Abstract

The invention discloses a method for extracting astragaloside by microorganisms.The method includes: performing mixed fermentation of potato starch, complex enzymes and distillery yeasts to enable the potato starch to be completely used by the distillery yeasts to generate ethyl alcohol and mash; soaking a certain quantity of ground Radix Astragali powder into the fermented mash, well mixing for culturing for several days, and performing solid-liquid separation; concentrating and drying liquid obtained by separation to obtain astragaloside.The method for extracting the astragaloside by the microorganisms has the advantages that astragaloside extraction rate is above 82%, a great quantity of soluble saccharides are consumed, the content of the astragaloside in crude extract is high and can reach 61.6% above, and a purification process is avoided or procedures are simplified for further extraction; technical simplicity and low extraction cost are realized.

Description

technical field [0001] The invention belongs to the technical field of extracting Chinese patent medicines, and in particular relates to a method for extracting astragaloside IV by microorganisms. Background technique [0002] Astragalus is a plant of the genus Astragalus in the leguminous family, and it is a traditional Chinese medicine in my country. It is sweet in nature, slightly warm, and belongs to the spleen and lung meridians. It has the effects of invigorating qi and solidifying the exterior, diuretic and detoxification, evacuating pus, astringing sores and promoting granulation. The compounds isolated from Astragalus mainly include saponins, flavonoids, biphenyl derivatives, polysaccharides, etc. Modern pharmacological studies have shown that saponins and flavonoids are the most important biologically active components of Astragalus. In order to provide a reliable method for the quality evaluation of traditional Chinese medicine Astragalus membranaceus, and to pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P33/20
Inventor 岳军堂
Owner 岳军堂