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Veterinary compound levamisole hydrochloride suspension oral liquid and preparation method thereof

A technology of levamisole hydrochloride and oral liquid, which is applied in the directions of medical preparations containing active ingredients, liquid delivery, pharmaceutical formulations, etc., can solve problems such as troublesome use, achieve prevention of parasitic infection, improve anti-stress effect and immunity Effect

Active Publication Date: 2016-07-20
CHONGQING BULL ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, levamisole deworming drugs are mostly injections on the market, which is quite troublesome to use in animal husbandry

Method used

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  • Veterinary compound levamisole hydrochloride suspension oral liquid and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Accurately weigh 400g of sodium carboxymethyl cellulose, add 5L of water while stirring, and soak for more than 4 hours, wait for natural swelling, and stir evenly;

[0056] (2) Accurately weigh 200g of agar powder, heat it with 5L of water until completely dissolved, and set aside;

[0057] (3) Take 5L of propylene glycol into the liquid mixing container, add 3.5kg of loxanamide, 100g of sodium benzoate and 40g of tartrazine, stir evenly, add the pre-soaked sodium carboxymethylcellulose solution, crush the agar solution and pour it out into, stir evenly;

[0058] (4) Add 2.0kg of levamisole hydrochloride, 400g of cobalt sulfate, 50g of disodium edetate, 100ml of Tween-80 and 300g of sodium citrate, add water to 100L, stir well, and homogenize while stirring machine;

[0059] (5) Adjust the pH value to 4.5-5.0 with citric acid and sodium citrate to obtain the veterinary compound levamisole hydrochloride suspension oral liquid.

Embodiment 2

[0061] (1) Accurately weigh 400g of sodium carboxymethyl cellulose, add 5L of water while stirring, and soak for more than 4 hours, wait for natural swelling, and stir evenly;

[0062] (2) Accurately weigh 200g of agar powder, heat it with 5L of water until completely dissolved, and set aside;

[0063] (3) Take 8L of propylene glycol into the liquid mixing container, add 3.5kg of loxanamide, 100g of sodium benzoate and 40g of tartrazine, stir evenly, add the pre-soaked sodium carboxymethylcellulose solution, crush the agar solution and pour it out into, stir evenly;

[0064] (4) Add 2.0kg of levamisole hydrochloride, 400g of cobalt sulfate, 50g of disodium edetate, 100ml of Tween-80 and 300g of sodium citrate, add water to 100L, stir well, and homogenize while stirring machine;

[0065] (5) Adjust the pH value to 4.5-5.0 with citric acid and sodium citrate to obtain the veterinary compound levamisole hydrochloride suspension oral liquid.

Embodiment 3

[0067] (1) Accurately weigh 400g of sodium carboxymethyl cellulose, add 5L of water while stirring, and soak for more than 4 hours, wait for natural swelling, and stir evenly;

[0068] (2) Accurately weigh 200g of agar powder, heat it with 5L of water until completely dissolved, and set aside;

[0069] (3) Take 5L of propylene glycol into the liquid mixing container, add 3.5kg of loxanamide, 100g of sodium benzoate and 40g of tartrazine, stir evenly, add the pre-soaked sodium carboxymethylcellulose solution, crush the agar solution and pour it out into, stir evenly;

[0070] (4) Add 3.0kg of levamisole hydrochloride, 400g of cobalt sulfate, 50g of disodium edetate, 100ml of Tween-80 and 300g of sodium citrate, add water to 100L, stir well, and homogenize while stirring machine;

[0071] (5) Adjust the pH value to 4.5-5.0 with citric acid and sodium citrate to obtain the veterinary compound levamisole hydrochloride suspension oral liquid.

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Abstract

The invention discloses a veterinary compound levamisole hydrochloride suspension oral liquid and a preparation method thereof. The compound levamisole hydrochloride suspension oral liquid is composed of levamisole hydrochloride, oxyclozanide, cobalt sulfate, agar powder, a suspending aid, a wetting agent, disodium ethylene diamine tetraacetate and a surfactant. A stable and uniform dispersion system is formed under the action of mechanical shearing force by wetting with the wetting agent and using the dispersion characteristic of the surfactant and the suspension aiding characteristic of the suspending aid on the basis of levamisole hydrochloride and oxyclozanide in order to prepare the compound suspension oral liquid, and the oral liquid is taken by cattle and sheep in a feed mixing or drinking water mixing mode to dispel parasites in order to treat and prevent infection of gastrointestinal nematodes, lung nematodes and other parasites in clinics and animal production, and can improve the stress resistance and the immunity of animals.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, in particular to a compound levamisole hydrochloride suspension oral liquid for animals and a preparation method thereof. Background technique [0002] Gastrointestinal nematodes are a general term for parasitic diseases caused by various nematodes that live in the digestive tract. There are many kinds of nematodes, they are widely distributed, and most of them are mixed infections. They are one of the important parasitic diseases of livestock and cause serious economic losses to animal husbandry. There are many parasites in cattle and sheep, which often cause certain economic losses to the animal husbandry due to insufficient attention or improper prevention and treatment. [0003] Levamisole hydrochloride is the hydrochloride salt of levamisole. It is a broad-spectrum, high-efficiency, and low-toxicity anthelmintic drug commonly used in veterinary clinics and animal production. There...

Claims

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Application Information

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IPC IPC(8): A61K31/609A61K9/10A61P33/10A61K31/429
Inventor 吴俊伟姜波陈红伟邓开峰
Owner CHONGQING BULL ANIMAL PHARMA
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