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Traditional Chinese medicine composition for treating keratitis as well as preparation method and application thereof

A composition and keratitis technology, applied in the field of traditional Chinese medicine extraction and application, can solve the problem of no active ingredient extraction and the like

Inactive Publication Date: 2016-07-20
毕宏生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] As mentioned above, although various traditional Chinese medicine preparations that can be used to treat keratitis are disclosed in the prior art, these preparations are simply a mixture of original Chinese herbal medicines without special extraction of their active ingredients

Method used

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  • Traditional Chinese medicine composition for treating keratitis as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating keratitis as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating keratitis as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0087] Preparation Example 1: Preparation of Radix Paeoniae Rubra Extract

[0088] A1: Completely pulverize the dry Chishao to obtain Chishao powder;

[0089] A2: Add the Chishao powder to 8 times the weight of n-butanol aqueous solution with a concentration of 50% by mass, stir and extract at 80°C for 75 minutes, and filter to obtain the extract;

[0090] A3: Concentrate the extract until there is no alcohol smell to obtain the extract, dissolve the extract with an appropriate amount of ethanol, add it to the top of the 300-400 mesh neutral alumina column, fully absorb it, and obtain the elution column;

[0091] A4: First wash with 2 times the column volume of petroleum ether, then wash with 3 times the column volume of a mixture of ethyl acetate and acetone with a volume ratio of 1:2, and collect the eluate of the mixture;

[0092] A5: Add an equal volume of deionized water to the eluent, oscillate fully, separate layers to obtain an organic layer, concentrate under reduced...

preparation example 1-1

[0093] Comparative Preparation Examples 1-1 to 1-6: Preparation of Radix Paeoniae Rubra Extract

[0094] Except that the n-butanol in the step A2 of the preparation example 1 is replaced successively by methanol, ethanol, n-propanol, isopropanol, sec-butanol and tert-butanol, other operations are all the same, and the preparation example 1 is repeated, thus Comparative Preparation Examples 1-1 to 1-6 were obtained in sequence, and the obtained Radix Paeoniae Rubra extracts were named CS1, CS2, CS3, CS4, CS5 and CS6 in sequence.

preparation example 2

[0095] Preparation Example 2: Preparation of Radix Paeoniae Alba Extract

[0096] B1: Pulverize the white spoon and pass through a 100-mesh sieve to obtain Radix Paeoniae Alba powder;

[0097] B2: Radix Paeoniae Alba powder was reflux extracted for 2 hours with an ethanol aqueous solution with a mass percentage concentration of 60% which was 3.5 times its mass, to obtain an extract;

[0098] B3: Concentrate the extract to obtain a viscous substance, which is dried, pulverized, ground, and passed through a 100-mesh sieve to obtain the Radix Paeoniae Alba extract, which is named BS.

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Abstract

The invention relates to a traditional Chinese medicine composition for treating keratitis. The traditional Chinese medicine composition comprises a radix paeoniae rubra extract, a radix paeoniae alba extract, a Szechwan lovage rhizome extract, a radix arnebiae extract, a radix astragali extract, a poria cocos extract, a flos chrysanthemi extract, a radix scrophulariae extract, a radix isatidis extract, a folium isatidis extract, a herba equiseti hiemalis extract, a radix platycodonis extract, a rhizoma acori tatarinowii extract and a radix puerariae extract. The invention furthermore relates to a preparation method for the traditional Chinese medicine composition. The traditional Chinese medicine composition has a good curative effect for keratitis, thereby having wide application prospects in ocular clinical treatment.

Description

technical field [0001] The invention relates to an active ingredient of traditional Chinese medicine and its preparation method and application, more specifically to a traditional Chinese medicine composition for treating keratitis, its preparation method and application, and belongs to the technical field of extraction and application of traditional Chinese medicine. Background technique [0002] Among human eye diseases, keratitis is the most frequent and frequent eye disease, which usually manifests as dry eyes, astringent, pain, blurred vision, foreign body sensation in the eyes, photophobia, windphobia, and easy tearing , increased secretions, etc., bring great inconvenience to the patient's life and work. [0003] With the development of medicine and the advancement of technology, it has been proved that keratitis is an inflammatory lesion of the cornea caused by bacterial infection, virus, fungus, etc. At present, the treatment of keratitis mainly uses chemical drugs...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P27/02
CPCA61K36/888A61K36/076A61K36/11A61K36/195A61K36/236A61K36/287A61K36/30A61K36/315A61K36/346A61K36/481A61K36/488A61K36/65A61K36/704A61K36/71A61K36/808A61K36/855A61K2236/333A61K2236/51A61K2236/55A61K2300/00
Inventor 毕宏生解孝锋郭俊国郭大东宋继科
Owner 毕宏生
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