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Method for preparing biodegradable polymer self-expansion type intravascular stent based on 3D printing technology

A technology for degrading polymers and vascular stents, applied in the field of biodegradable polymer self-expanding vascular stents based on 3D printing technology. The effect of improving long-term patency

Inactive Publication Date: 2016-07-20
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The shape of the stent is relatively fixed, most of which are tubular and spiral, and the shape is limited, so it is difficult to realize individualized design

Method used

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  • Method for preparing biodegradable polymer self-expansion type intravascular stent based on 3D printing technology
  • Method for preparing biodegradable polymer self-expansion type intravascular stent based on 3D printing technology
  • Method for preparing biodegradable polymer self-expansion type intravascular stent based on 3D printing technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Synthesis of biodegradable polylactic acid-based shape memory polyurethane

[0032] With a molar ratio of 7:3 D,L - Lactide ( D,L -LA) with e- Caprolactone ( e- CL) as raw material, through ring-opening polymerization

[0033] Preparation of random copolymer PCLA, PCLA and hexamethylene diisocyanate (HDI) and flexible oligomer polytetrahydrofuran (PTMEG) chain extension to prepare biodegradable polylactic acid-based shape memory polyurethanes (PCLAUs), in which HDI and PCLA The mol ratio is 1.2:1, and the consumption of PTMEG is 10% of system gross mass;

[0034] (2) Biodegradable polylactic acid-based shape memory polyurethanes (PCLAUs) / Fe 3 o 4 Synthesis of Nanocomposites

[0035] The PCLAUs obtained in step (1) and the surface-modified magnetic Fe 3 o 4 Composite nanoparticles to prepare PCLAUs / Fe 3 o 4 nanocomposites; among them, the magnetic Fe 3 o 4 Nanoparticles are surface treated with oleic acid. In the composite system, the magnetic Fe 3 o 4 ...

Embodiment 2

[0047] (1) Synthesis of biodegradable polylactic acid-based shape memory polyurethane

[0048] With a molar ratio of 8:2 D,L - Lactide ( D,L -LA) with e- Caprolactone ( e- CL) as raw material, through ring-opening polymerization

[0049] Preparation of random copolymer PCLA, PCLA and hexamethylene diisocyanate (HDI) and flexible oligomer polytetrahydrofuran (PTMEG) chain extension to prepare biodegradable polylactic acid-based shape memory polyurethanes (PCLAUs), in which HDI and PCLA The mol ratio is 1.04:1, and the consumption of PTMEG is 10% of system gross mass;

[0050] (2) Biodegradable polylactic acid-based shape memory polyurethanes (PCLAUs) / Fe 3 o 4 Synthesis of Nanocomposites

[0051] The PCLAUs obtained in step (1) and the surface-modified magnetic Fe 3 o 4 Composite nanoparticles to prepare PCLAUs / Fe 3 o 4 nanocomposites; among them, the magnetic Fe 3 o 4 Nanoparticles are surface treated with oleic acid. In the composite system, the magnetic Fe 3 o ...

Embodiment 3

[0065] (1) Synthesis of biodegradable polylactic acid-based shape memory polyurethane

[0066] With a molar ratio of 9:1 D,L - Lactide ( D,L -LA) with e- Caprolactone ( e- CL) as raw material, through ring-opening polymerization

[0067] Preparation of random copolymer PCLA, PCLA and hexamethylene diisocyanate (HDI) and flexible oligomer polytetrahydrofuran (PTMEG) chain extension to prepare biodegradable polylactic acid-based shape memory polyurethanes (PCLAUs), in which HDI and PCLA The mol ratio is 1.10:1, and the consumption of PTMEG is 10% of system gross mass;

[0068] (2) Biodegradable polylactic acid-based shape memory polyurethanes (PCLAUs) / Fe 3 o 4 Synthesis of Nanocomposites

[0069] The PCLAUs obtained in step (1) and the surface-modified magnetic Fe 3 o 4 Composite nanoparticles to prepare PCLAUs / Fe 3 o 4 nanocomposites; among them, the magnetic Fe 3 o 4 Nanoparticles are surface treated with oleic acid. In the composite system, the magnetic Fe 3 o ...

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Abstract

The invention relates to a method for preparing a biodegradable polymer self-expansion type intravascular stent based on 3D printing technology.The method includes the specific steps of synthesizing polylactic acid-based shape-memory polyurethane / Fe304 nanocomposite material with good biocompatibility and biodegradability, and making the composite material into the intravascular stent through the Fused Deposition Modeling technology.In addition, in order to increase the blood vessel endothelium repair speed, sirolimus, heparin, endothelial growth factors or the like are selectively introduced to the stent surface through electrostatic spinning.A 'time'dimension is added for the shape-memory function of the base material, and combined with the 3D printing technology, a 4D forming concept is given to the stent.By means of the magnetocaloric effect of Fe304, shape recovery of the shape-memory polymer can be remotely excited, so that the intravascular stent expands automatically, balloon dilatation is not required during stent implantation, axial shortening during balloon dilatation and radial resilience during withdraw of the stent are avoided, and damage of blood vessels is reduced to a minimum level.In addition, the introduction of Fe304 solves the problem that a polymer stent has poor development.

Description

technical field [0001] The invention belongs to the field of polymer materials and biomedical devices, and in particular relates to a method for preparing a biodegradable polymer self-expanding vascular stent based on 3D printing technology. Background technique [0002] Cardiovascular disease is one of the most prevalent and fatal diseases facing the world, with occlusive vascular disease being the leading culprit. At present, the most effective treatment for most patients is percutaneous coronary implantation of vascular stents. Traditional metal stents, as a foreign body, are likely to cause thrombus formation in the stent, and subsequent intimal hyperplasia will also cause vascular restenosis, resulting in infertility. Benign cardiovascular events occur, and the mortality rate of patients reaches more than 40%. Especially for pediatric patients with cardiovascular disease, follow-up surgery is required to remove the stent, which will bring secondary harm to the patient. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/16
CPCA61L31/128A61L31/16A61L2300/20A61L2300/236A61L2300/252A61L2400/16A61L2430/22
Inventor 顾书英金升朋
Owner TONGJI UNIV
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