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Method for preparing medical ultrafine barium sulfate

A technology of ultra-fine barium sulfate and preparation steps, which is applied in the field of preparation of medical ultra-fine barium sulfate, can solve problems such as uneven particle size distribution, low purity, and particle agglomeration, so as to simplify the production process, reduce production costs, and improve production efficiency. quality effect

Inactive Publication Date: 2016-07-20
郭迎庆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem solved by the present invention: Aiming at the problems of uneven particle size distribution, low purity and serious particle agglomeration in the preparation process that occur in the current traditional preparation process of ultrafine barium sulfate powder, a medical superfine barium sulfate powder is provided. The preparation method of fine barium sulfate, the present invention first in sucrose-peptone culture medium, cultivates sporophage cellulobacterium, then mixes it with non-woven scrap fiber, obtains bacterial fermented polysaccharide with special flocculation, in liquid phase During the process of precipitation to form barium sulfate, bacterial fermented polysaccharides can form a protective film on the surface of barium sulfate ions, so that it will no longer grow and be flocculated and precipitated quickly, and then use the deflocculation effect of sodium citrate to disperse it into Semi-fluid state, that is, a medical ultra-fine barium sulfate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] Weigh 5g of filter paper, cut it into 0.5cm pieces, then weigh 3g of sucrose, 0.5g of peptone, and 15g of agar in sequence, add them to a petri dish filled with 1L of deionized water, and use a concentration of 4mol / L sodium bicarbonate solution Adjust the pH to 7.2, then transfer the mixture to a pressure steam sterilizer, and sterilize it under the condition of 0.08MPa for 20 minutes to obtain a culture medium; inoculate the sporophage cellulobacteria into the above culture medium according to the inoculum size of 4%, and then Move the culture medium to a constant temperature incubator, cultivate it at 30°C for 6 days, rinse the surface of the culture medium with 100mL deionized water, collect the washing liquid, and obtain mycelium suspension; weigh 200g of non-woven fabric, cut it into pieces Add 0.6cm fragments into a reaction kettle filled with 200mL of deionized water, raise the temperature to 40°C, start the stirrer, set the speed at 300r / min, stir at a constant ...

example 2

[0023] Weigh 8g of filter paper, cut it into 1cm pieces, then weigh 4g of sucrose, 0.8g of peptone, and 20g of agar in turn, add them to a petri dish filled with 1.5L of deionized water, and use a concentration of 5mol / L sodium bicarbonate solution Adjust the pH to 7.3, then transfer the mixture to a pressure steam sterilizer, and sterilize it under the condition of 0.09MPa for 25 minutes to obtain a culture medium; inoculate the sporophage cellulobacteria into the above culture medium according to the inoculum size of 5%, and then Move the culture medium to a constant temperature incubator, cultivate it at 32°C for 7 days, rinse the surface of the culture medium with 150mL deionized water, collect the washing liquid, and obtain mycelium suspension; weigh 250g of non-woven fabric, cut it into pieces Add 0.7cm fragments into a reaction kettle filled with 250mL of deionized water, raise the temperature to 42°C, start the stirrer, set the speed at 400r / min, stir at a constant temp...

example 3

[0027] Weigh 10g of filter paper, cut it into 1.5cm pieces, then weigh 5g of sucrose, 1.0g of peptone, and 25g of agar in sequence, add them to a petri dish filled with 2L of deionized water, and use a concentration of 6mol / L sodium bicarbonate solution Adjust the pH to 7.5, then transfer the mixture to a pressure steam sterilizer, and sterilize it under the condition of 0.1 MPa for 30 minutes to obtain a culture medium; inoculate the sporophage cellulobacteria into the above culture medium according to the inoculum size of 6%, and then Move the culture medium to a constant temperature incubator, cultivate it at 35°C for 8 days, rinse the surface of the culture medium with 200mL deionized water, collect the washing liquid, and obtain mycelial suspension; weigh 300g of non-woven fabric, cut it into pieces Add 0.8cm fragments into a reaction kettle filled with 300mL of deionized water, raise the temperature to 45°C, start the stirrer, set the speed at 500r / min, stir at a constant...

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Abstract

The invention discloses a method for preparing medical ultrafine barium sulfate and belongs to the field of drug synthesis. According to the method, firstly, culture is carried out in a saccharose peptone culture medium so as to obtain Sporocytophaga, then, the Sporocytophaga is mixed with non-woven fabric scrap fibers so as to obtain bacterial-fermented polysaccharides with a special flocculation action, the bacterial-fermented polysaccharides can form a layer of protective film on the surface of each barium sulfate ion during the liquid-phase precipitated production of barium sulfate so as to enable the barium sulfate not to increase any more and to be subjected to flocculating precipitation quickly, and the barium sulfate is dispersed into a semi-fluid state by using the deflocculation action of sodium citrate, thereby obtaining the medical ultrafine barium sulfate. According to the method, during the preparation of the obtained medical ultrafine barium sulfate, by using the relatively high flocculating and protecting actions of the polysaccharides obtained through bacterial fermentation, the prepared barium sulfate has the advantages of relatively small particle size, uniform particle size distribution, relatively high purity and good dispersity.

Description

technical field [0001] The invention discloses a preparation method of medical ultrafine barium sulfate, which belongs to the field of medicine synthesis. Background technique [0002] Barium sulfate, commonly known as barite, is an important inorganic chemical product. Due to its easy development, low cost, low hardness and high specific gravity, opaque to X-rays, pure white and non-toxic, and many other superior properties, barium sulfate Has become an irreplaceable inorganic material. Generally, the particle size of ultra-fine barium sulfate powder is about 0.1 micron, which is about one percent of ordinary fine barium sulfate. Due to its large specific surface area, small size and quantum size effect, it has characteristics that conventional materials do not have. It is often used in the field of medicine, but because the particles of ultrafine barium sulfate powder are very small, the dispersion is poor, and agglomeration often occurs, so its application is limited to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01F11/46A61K49/04
CPCC01F11/462A61K49/0404
Inventor 郭迎庆许博伟
Owner 郭迎庆