Gold-nanoparticle fluorescence probe and preparation method and application thereof

A fluorescent probe and gold nanotechnology, applied in the field of fluorescent probes, can solve the problems of complicated preparation steps and long time required, and achieve the effects of simple detection means, rapid reaction and simple reaction conditions.

Inactive Publication Date: 2016-08-03
SHANXI UNIV
3 Cites 1 Cited by

AI-Extracted Technical Summary

Problems solved by technology

The reported method requires the use of the strong reducing agent NaBH 4 , surfactant (hexadecyltrimethylammoniu...
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Abstract

The invention provides a gold-nanoparticle fluorescence probe and a preparation method and application thereof. The preparation method comprises the steps that 1-10 parts of 3-5 mmol/L chloroauric acid aqueous solution is heated to 80 DEG C to 120 DEG C, 1-5 parts of 4-6 mmol/L 2-mercapto-4-methyl-5-thiazoleacetic acid aqueous solution is added to the chloroauric acid aqueous solution, continuous heating stirring is conducted for 5 min to 30 min, and the gold-nanoparticle fluorescence probe is obtained. The preparation method is simple in reaction condition, rapid and friendly to environment. 2-mercapto-4-methyl-5-thiazoleacetic acid serves as a reducing agent and a protective agent, 2-mercapto-4-methyl-5-thiazoleacetic acid itself has the reducing property, and addition of a frequently-used reducing agent sodium borohydride, surfactants and the like is avoided. The gold-nanoparticle fluorescence probe presents intense blue fluorescence on the fluorescence emission peak near 430 nm, the gold-nanoparticle fluorescence probe is good in stability when preserved at room temperature and can be used for high-sensitivity and high-selectivity detection of Fe<3+>, the detection process is simple, convenient and rapid, and the detection result is accurate.

Application Domain

Fluorescence/phosphorescenceLuminescent compositions

Technology Topic

Protective AgentsNanoparticle +11

Image

  • Gold-nanoparticle fluorescence probe and preparation method and application thereof
  • Gold-nanoparticle fluorescence probe and preparation method and application thereof
  • Gold-nanoparticle fluorescence probe and preparation method and application thereof

Examples

  • Experimental program(10)

Example Embodiment

[0021] Example 1
[0022] 7mL4mmol/L chloroauric acid aqueous solution was heated to 100 ℃, and then 2mL5mmol/L 2-mercapto-4-methyl-5-thiazole acetic acid aqueous solution was added to the above chloroauric acid aqueous solution and continued to heat and stir for 20min to obtain gold nano-fluorescence. probe. The fluorescence emission peak of the gold nano-fluorescent probe is around 430 nm, showing strong blue fluorescence with a quantum yield of 4.5%.

Example Embodiment

[0023] Example 2
[0024] Heat 10 mL of 4mmol/L chloroauric acid aqueous solution to 120°C, then add 1 mL of 5 mmol/L 2-mercapto-4-methyl-5-thiazole acetic acid aqueous solution to the above chloroauric acid aqueous solution and continue to heat and stir for 30 min to obtain gold nano-fluorescence. probe. The fluorescence emission peak of the gold nano-fluorescent probe is around 430 nm, showing strong blue fluorescence, and the quantum yield is 3.5%.

Example Embodiment

[0025] Example 3
[0026] Heat 1 mL of 4 mmol/L chloroauric acid aqueous solution to 110°C, then add 5 mL of 5 mmol/L 2-mercapto-4-methyl-5-thiazole acetic acid aqueous solution to the above chloroauric acid aqueous solution and continue to heat and stir for 20 min to obtain gold nano-fluorescence. probe. The fluorescence emission peak of the gold nano-fluorescent probe is around 430 nm, showing strong blue fluorescence with a quantum yield of 2.7%.

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Description & Claims & Application Information

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